Neuron-derived orphan receptor 1

Nomenclature: Neuron-derived orphan receptor 1

Systematic Nomenclature: NR4A3

Family: 4A. Nerve growth factor IB-like receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human 637 9q22 NR4A3 nuclear receptor subfamily 4, group A, member 3 6,8
Mouse 627 4B2 Nr4a3 nuclear receptor subfamily 4, group A, member 3 21
Rat 628 5q22 Nr4a3 nuclear receptor subfamily 4, group A, member 3 14
Previous and Unofficial Names
CSMF
CHN
MINOR
NOR1
Neuron-derived orphan receptor
mitogen-induced nuclear orphan receptor
NOR-2
neuron-derived orphan receptor 1
neuron-derived orphan receptor 1/2
nuclear hormone receptor NOR-1/NOR-2
nuclear receptor subfamily 4 group A member 3
nuclear receptor subfamily 4, group A, member 3
NOR-1
TEC
AI573420
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
NURSA Receptor
OMIM
Orphanet Gene
PharmGKB Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniProtKB
Wikipedia
Natural/Endogenous Ligands
Comments: Orphan
Agonist Comments
Based on alignment with the related NR4A subfamilly members and on 3D structure analysis of the LBD, NR4A3 as the others NR4A receptors have been shown to be unable to interact with ligands due to the lack of a ligand binding pocket (LBP) [1,4,18].
DNA Binding
Structure:  Monomer, Homodimer, Heterodimer
HRE core sequence:  AAAGGTCA
Response element:  Half site, Other - see comments
DNA Binding Comments
NR4A3 is able to interact with DNA in various manner. As monomers, NR4A3 as other N4R4A subfamily members interact with the so-called NBRE sequence (AAAGGTCA). NR4A1 is also able to homodimerize and to heterodimerize with other NR4A family members and bind the so-called NuRE sequence which has the structure of an ER10 (two AGGTCA elements as everted repeats spaced by 10 bp, the two immediate 5’ bases of each element being As).
Co-binding Partners
Name Interaction Effect Reference
Nuclear receptor related 1 Physical DNA binding 11
Neuron-derived orphan receptor 1 Physical DNA binding 11
Main Co-regulators
Name Activity Specific Ligand dependent AF-2 dependent Comments References
SIX3 Co-activator Yes No No SIX3 seems to act as a coactivator for NR4A3 dependent transcriptional activation but as a corepressor for the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. SIX3 interacts with the DNA Binding domain of Nor1. 9,16
MED1 Co-activator No No No TRAP220 interacts with the NR4A1-3 subgroup in an AF-1-dependent manner in a cellular context. 20
EP300 Co-activator No No No SRC-2 recruitment allows interaction with p300 19
NCOA2 Co-activator No No No NR4A3 seems to interact with SRC-2 via its a/B domain. SRC-2 modulates the activity of the N-terminal AF-1 domain.-terminal AF-1 domain. 19
KAT2B Co-activator No No No SRC-2 recruitment allows interaction with pCAF 19
Main Target Genes
Name Species Effect Technique Comments References
POMC Human Activated Transient transfection, EMSA, Other NR4A3 like NR4A1 is able to stimulate the expression of the POMC gene via its interaction with the NuRE element in the POMC promoter. (All species) 10,13
Tissue Distribution
Skeletal muscles, fetal heart, CNS, pituitary, adrenal, heart, muscle, thymus, kidney
Species:  Human
Technique:  Northern, in situ, Western, immunohistology, other
References:  6,8,14
Tissue Distribution Comments
NR4A3 is expressed as a complex pattern of transcripts (6.5 kb, 5.0 kb, 2.0 kb) in skeletal muscles, fetal heart as well as at lower levels in other tissues. The three NR4A subfamily members are expressed in a complex pattern in the nervous system where they are induced as part of the immediate early response to stimuli such as growth factors, membrane depolarisation and seizure. Their expression pattern outside the nervous system is quite large. NR4A3 is expressed in the pituitary, adrenal, heart, muscle, thymus and kidney. (NB: similar expression patterns observed in rodents).
Physiological Consequences of Altering Gene Expression
NR4A3 null mice: Disruption of the Nor-1 gene results in inner ear defects and partial bidirectional circling behavior, and an embryonic lethal phenotype around E8,5 for the NR4A3 null embryo has also been described.
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  3,17
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0002961 abnormal axon guidance PMID: 15456880 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0003651 abnormal axon outgrowth PMID: 15456880 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0000172 abnormal bone marrow cell number PMID: 17515897 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0006410 abnormal common myeloid progenitor cell morphology PMID: 17515897 
Nr4a3tm1Wnt Nr4a3tm1Wnt/Nr4a3tm1Wnt
involves: 129S4/SvJae
MGI:1352457  MP:0002085 abnormal embryonic tissue morphology PMID: 13129926 
Nr4a3+|Nr4a3tm1Wnt Nr4a3tm1Wnt/Nr4a3+
involves: 129S4/SvJae
MGI:1352457  MP:0002085 abnormal embryonic tissue morphology PMID: 13129926 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0006011 abnormal endolymphatic duct morphology PMID: 11784868 
Nr4a3tm1Wnt Nr4a3tm1Wnt/Nr4a3tm1Wnt
involves: 129S4/SvJae
MGI:1352457  MP:0001695 abnormal gastrulation PMID: 13129926 
Nr4a3tm1Wnt Nr4a3tm1Wnt/Nr4a3tm1Wnt
involves: 129S4/SvJae
MGI:1352457  MP:0002174 abnormal gastrulation movements PMID: 13129926 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0000808 abnormal hippocampus development PMID: 15456880 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0008284 abnormal hippocampus pyramidal cell layer PMID: 15456880 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0005460 abnormal leukopoiesis PMID: 17515897 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0001601 abnormal myelopoiesis PMID: 17515897 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0002428 abnormal semicircular canal PMID: 11784868 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0000689 abnormal spleen morphology PMID: 17515897 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0000046 abnormal sulcus ampullaris morphology PMID: 11784868 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0000703 abnormal thymus morphology PMID: 17515897 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0004742 abnormal vestibular system physiology PMID: 11784868 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0001577 anemia PMID: 17515897 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0001395 bi-directional circling PMID: 11784868 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0001265 decreased body size PMID: 17515897 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0009971 decreased hippocampus pyramidal cell number PMID: 15456880 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0005016 decreased lymphocyte cell number PMID: 17515897 
Nr4a3+|Nr4a3tm1Wnt Nr4a3tm1Wnt/Nr4a3+
involves: 129S4/SvJae
MGI:1352457  MP:0003984 embryonic growth retardation PMID: 13129926 
Nr4a3tm1Wnt Nr4a3tm1Wnt/Nr4a3tm1Wnt
involves: 129S4/SvJae
MGI:1352457  MP:0006206 embryonic lethality before turning of embryo PMID: 13129926 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0000599 enlarged liver PMID: 17515897 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0000702 enlarged lymph nodes PMID: 17515897 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0000691 enlarged spleen PMID: 17515897 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0001505 hunched posture PMID: 17515897 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0001399 hyperactivity PMID: 11784868 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0001525 impaired balance PMID: 11784868 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0005011 increased eosinophil cell number PMID: 17515897 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0000322 increased granulocyte number PMID: 17515897 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0004809 increased hematopoietic stem cell number PMID: 17515897 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0000218 increased leukocyte cell number PMID: 17515897 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0003203 increased neuron apoptosis PMID: 15456880 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0000219 increased neutrophil cell number PMID: 17515897 
Nr4a2+|Nr4a2tm1Tpe|Nr4a3tm1Dgen Nr4a2tm1Tpe/Nr4a2+,Nr4a3tm1Dgen/Nr4a3tm1Dgen
involves: 129P2/OlaHsd
MGI:1352456  MGI:1352457  MP:0008235 increased susceptibility to neuronal excitotoxicity PMID: 20566846 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0002906 increased susceptibility to pharmacologically induced seizures PMID: 15456880 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0002026 leukemia PMID: 17515897 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0003240 loss of hippocampal neurons PMID: 15456880 
Nr4a2+|Nr4a2tm1Tpe|Nr4a3tm1Dgen Nr4a2tm1Tpe/Nr4a2+,Nr4a3tm1Dgen/Nr4a3tm1Dgen
involves: 129P2/OlaHsd
MGI:1352456  MGI:1352457  MP:0003674 oxidative stress PMID: 20566846 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0002082 postnatal lethality PMID: 17515897 
Nr4a3+|Nr4a3tm1Wnt Nr4a3tm1Wnt/Nr4a3+
involves: 129S4/SvJae
MGI:1352457  MP:0002080 prenatal lethality PMID: 13129926 
Nr4a1tm1Jmi|Nr4a3tm1Omc Nr4a1tm1Jmi/Nr4a1tm1Jmi,Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
MGI:1352454  MGI:1352457  MP:0000420 ruffled hair PMID: 17515897 
Nr4a3tm1Omc Nr4a3tm1Omc/Nr4a3tm1Omc
involves: 129S/SvEv * C57BL/6
MGI:1352457  MP:0003997 tonic-clonic seizures PMID: 15456880 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Extraskeletal myxoid chondrosarcoma
OMIM:  612237
Orphanet:  209916
Role: 
Comments: 
References:  2,5,7-8
Mutations not determined
Biologically Significant Variants
Type:  Splice variant
Species:  Human
Description:  NR4A3 b This variant differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) contains a longer N-terminus compared to the canonical isoform.
Amino acids:  637
Protein accession: 
References:  15
Type:  Splice variant
Species:  Human
Description:  NR4A3 c: This variant, also known as NOR-1alpha, contains an additional segment in the coding region compared to canonical NR4A3 mRNA. This segment introduces a stop codon in the sequence. The resulting isoform (c) contains a shorter and distinct C-terminus compared to the canonical isoform.
Amino acids:  443
Protein accession: 
References:  12,15

References

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1. Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, Wisely B, Caravella JA, Lambert MH, Reinking JL, Krause H, Thummel CS, Willson TM, Mangelsdorf DJ. (2003) The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell113 (6): 731-42. [PMID:12809604]

2. Clark J, Benjamin H, Gill S, Sidhar S, Goodwin G, Crew J, Gusterson BA, Shipley J, Cooper CS. (1996) Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. Oncogene12 (2): 229-35. [PMID:8570200]

3. DeYoung RA, Baker JC, Cado D, Winoto A. (2003) The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis. J. Biol. Chem.278 (47): 47104-9. [PMID:13129926]

4. Flaig R, Greschik H, Peluso-Iltis C, Moras D. (2005) Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain. J. Biol. Chem.280 (19): 19250-8. [PMID:15716272]

5. Gill S, McManus AP, Crew AJ, Benjamin H, Sheer D, Gusterson BA, Pinkerton CR, Patel K, Cooper CS, Shipley JM. (1995) Fusion of the EWS gene to a DNA segment from 9q22-31 in a human myxoid chondrosarcoma. Genes Chromosomes Cancer12 (4): 307-10. [PMID:7539287]

6. Hedvat CV, Irving SG. (1995) The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor. Mol. Endocrinol.9 (12): 1692-700. [PMID:8614405]

7. Labelle Y, Bussières J, Courjal F, Goldring MB. (1999) The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator. Oncogene18 (21): 3303-8. [PMID:10359536]

8. Labelle Y, Zucman J, Stenman G, Kindblom LG, Knight J, Turc-Carel C, Dockhorn-Dworniczak B, Mandahl N, Desmaze C, Peter M. (1995) Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation. Hum. Mol. Genet.4 (12): 2219-26. [PMID:8634690]

9. Laflamme C, Filion C, Bridge JA, Ladanyi M, Goldring MB, Labelle Y. (2003) The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. Cancer Res.63 (2): 449-54. [PMID:12543801]

10. Maira M, Martens C, Batsché E, Gauthier Y, Drouin J. (2003) Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment. Mol. Cell. Biol.23 (3): 763-76. [PMID:12529383]

11. Maira M, Martens C, Philips A, Drouin J. (1999) Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation. Mol. Cell. Biol.19 (11): 7549-57. [PMID:10523643]

12. Maltais A, Labelle Y. (2000) Structure and expression of the mouse gene encoding the orphan nuclear receptor TEC. DNA Cell Biol.19 (2): 121-30. [PMID:10701778]

13. Martens C, Bilodeau S, Maira M, Gauthier Y, Drouin J. (2005) Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor. Mol. Endocrinol.19 (4): 885-97. [PMID:15591535]

14. Ohkura N, Hijikuro M, Yamamoto A, Miki K. (1994) Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells. Biochem. Biophys. Res. Commun.205 (3): 1959-65. [PMID:7811288]

15. Ohkura N, Ito M, Tsukada T, Sasaki K, Yamaguchi K, Miki K. (1998) Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA. Gene211 (1): 79-85. [PMID:9573341]

16. Ohkura N, Ohkubo T, Maruyama K, Tsukada T, Yamaguchi K. (2001) The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3. Dev. Neurosci.23 (1): 17-24. [PMID:11173923]

17. Ponnio T, Burton Q, Pereira FA, Wu DK, Conneely OM. (2002) The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear. Mol. Cell. Biol.22 (3): 935-45. [PMID:11784868]

18. Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP, Perlmann T. (2003) Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature423 (6939): 555-60. [PMID:12774125]

19. Wansa KD, Harris JM, Muscat GE. (2002) The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment. J. Biol. Chem.277 (36): 33001-11. [PMID:12082103]

20. Wansa KD, Harris JM, Yan G, Ordentlich P, Muscat GE. (2003) The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. J. Biol. Chem.278 (27): 24776-90. [PMID:12709428]

21. Zetterström RH, Solomin L, Mitsiadis T, Olson L, Perlmann T. (1996) Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1. Mol. Endocrinol.10 (12): 1656-66. [PMID:8961274]

How to cite this page

4A. Nerve growth factor IB-like receptors: Neuron-derived orphan receptor 1. Last modified on 14/03/2014. Accessed on 23/09/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=631.