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sodium/potassium-transporting ATPase subunit α-1

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Target not currently curated in GtoImmuPdb

Target id: 833

Nomenclature: sodium/potassium-transporting ATPase subunit α-1

Family: Na+/K+-ATPases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 10 1023 1p13.1 ATP1A1 ATPase Na+/K+ transporting subunit alpha 1
Mouse 10 1023 3 44.3 cM Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
Rat 10 1023 2q34 Atp1a1 ATPase Na+/K+ transporting subunit alpha 1
Previous and Unofficial Names Click here for help
Na+/K+ ATPase α-1 subunit | sodium pump subunit α-1 | Nkaa1b | sodium/potassium-transporting ATPase subunit alpha-1 | Atpa-1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide | ATPase, Naﲯ� transporting, alpha 1 polypeptide | ATPase
Database Links Click here for help
Alphafold P05023 (Hs), Q8VDN2 (Mm), P06685 (Rn)
BRENDA 3.6.3.9
CATH/Gene3D 3.40.1110.10
ChEMBL Target CHEMBL1807 (Hs), CHEMBL3010 (Rn)
DrugBank Target P05023 (Hs)
Ensembl Gene ENSG00000163399 (Hs), ENSMUSG00000033161 (Mm), ENSRNOG00000030019 (Rn)
Entrez Gene 476 (Hs), 11928 (Mm), 24211 (Rn)
Human Protein Atlas ENSG00000163399 (Hs)
KEGG Enzyme 3.6.3.9
KEGG Gene hsa:476 (Hs), mmu:11928 (Mm), rno:24211 (Rn)
OMIM 182310 (Hs)
Pharos P05023 (Hs)
UniProtKB P05023 (Hs), Q8VDN2 (Mm), P06685 (Rn)
Wikipedia ATP1A1 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.6.3.9

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
digitoxin Small molecule or natural product Approved drug Ligand has a PDB structure Clf Inhibition 8.1 pIC50 2
⤷ pIC50 8.1 (IC50 8x10-9 M) [2]
digoxin Small molecule or natural product Approved drug Ligand has a PDB structure Clf Inhibition 6.4 pIC50 1
⤷ pIC50 6.4 (IC50 4x10-7 M) [1]
digoxin Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure Hs Inhibition - -
⤷
digitoxin Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure Hs Inhibition - -
⤷
acetyldigitoxin Small molecule or natural product Approved drug Primary target of this compound Hs Inhibition - -
⤷
deslanoside Small molecule or natural product Approved drug Primary target of this compound Hs Inhibition - -
⤷
View species-specific inhibitor tables

References

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1. De Munari S, Cerri A, Gobbini M, Almirante N, Banfi L, Carzana G, Ferrari P, Marazzi G, Micheletti R, Schiavone A et al.. (2003) Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds. J Med Chem, 46 (17): 3644-54. [PMID:12904068]

2. Templeton JF, Ling Y, Zeglam TH, LaBella FS. (1993) Synthesis of 20-hydroxy-, 20-amino-, and 20-nitro-14-hydroxy-21-nor-5 beta,14 beta-pregnane C-3 glycosides and related derivatives: structure-activity relationships of pregnanes that bind to the digitalis receptor. J Med Chem, 36 (1): 42-5. [PMID:8421289]

How to cite this page

Na+/K+-ATPases: sodium/potassium-transporting ATPase subunit α-1. Last modified on 12/04/2019. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=833.