sodium/potassium-transporting ATPase subunit α-1

Target id: 833

Nomenclature: sodium/potassium-transporting ATPase subunit α-1

Family: Na+/K+-ATPases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for sodium/potassium-transporting ATPase subunit α-1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1023 1p13 ATP1A1 ATPase Na+/K+ transporting subunit alpha 1
Mouse - 1023 3 44.30 cM Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
Rat - 1023 2q34 Atp1a1 ATPase Na+/K+ transporting subunit alpha 1
Previous and Unofficial Names
Na+/K+ ATPase α-1 subunit | sodium pump subunit α-1 | Nkaa1b | sodium/potassium-transporting ATPase subunit alpha-1 | Atpa-1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide | ATPase, Naﲯ� transporting, alpha 1 polypeptide
Database Links
BRENDA
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.6.3.9

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
digitoxin Clf Inhibition 8.1 pIC50 2
pIC50 8.1 (IC50 8x10-9 M) [2]
digoxin Clf Inhibition 6.4 pIC50 1
pIC50 6.4 (IC50 4x10-7 M) [1]
digoxin Hs Inhibition - -
digitoxin Hs Inhibition - -
acetyldigitoxin Hs Inhibition - -
deslanoside Hs Inhibition - -
View species-specific inhibitor tables

References

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1. De Munari S, Cerri A, Gobbini M, Almirante N, Banfi L, Carzana G, Ferrari P, Marazzi G, Micheletti R, Schiavone A et al.. (2003) Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds. J. Med. Chem.46 (17): 3644-54. [PMID:12904068]

2. Templeton JF, Ling Y, Zeglam TH, LaBella FS. (1993) Synthesis of 20-hydroxy-, 20-amino-, and 20-nitro-14-hydroxy-21-nor-5 beta,14 beta-pregnane C-3 glycosides and related derivatives: structure-activity relationships of pregnanes that bind to the digitalis receptor. J. Med. Chem.36 (1): 42-5. [PMID:8421289]

How to cite this page

Na+/K+-ATPases: sodium/potassium-transporting ATPase subunit α-1. Last modified on 11/08/2015. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=833.