Idiopathic pulmonary fibrosis

Disease ID:486
Name:Idiopathic pulmonary fibrosis
Associated with:1 target
6 immuno-relevant ligands
Database Links
Disease Ontology: DOID:0050156
Orphanet: ORPHA2032

Targets

dipeptidyl peptidase 9
References:  4

Ligands

Key to terms and symbols Click ligand name to view ligand summary Click column headers to sort
Ligand References Clinical and Disease comments
IL-13 1
Immuno Disease Comments: Failed clinical target for IPF and asthma.
pirfenidone
Immuno Disease Comments: Approved drug for IPF.
Clinical Use: Approved to treat idiopathic pulmonary fibrosis (IPF) [6]. | View clinical data
Bioactivity Comments: As the precise MMOA of this drug is not fully understood, we are unable to define a primary drug target. | View biological activity
lebrikizumab
Immuno Disease Comments: Repurposed clinical candidate for IPF (Phase 2).
Clinical Use: This antibody was originally tested as a treatment for refractory Hodgkin's lymphoma but was later repurposed as a potential asthma treatment [2]. The antibody entered Phase 2 trial for idiopathic pulmonary fibrosis (IPF) and Phase 3 trial for asthma. Business reports online indicate that Roche have discontinued lebrikizumab development in IPF following mixed results from their trials [1]. Click here to view ClinicalTrails.gov's listing of current lebrikizumab trials. | View clinical data
Bioactivity Comments: In humans lebrikizumab has systemic effects on markers of Th2 inflammation. Lebrikizumab treatment reduces serum immunoglobulin E (IgE) and interleukin-13 and -17 levels by approximately 25% [7].
The development of lebrikizumab is covered by patent US7674459, in which it appears to be the monoclonal designated as 228B/C-1 [5]. No binding constant is provided in this patent, although a graph representing binding of 228B/C-1 to IL-13 in an ELISA suggests a half max value of approximately 0.1nM. | View biological activity
KD025
Immuno Disease Comments: Phase 2 clinical candidate for IPF (NCT02688647).
Clinical Use: KD025 is in Phase 2 clinical trials evaluating its anti-inflammatory and anti-fibrotic activity. | View clinical data
GLPG1690
Immuno Disease Comments: Clinical candidate for IPF (Phase 2 NCT02738801)
Clinical Use: GLPG1690 is being evaluated in a Phase 2 safety, tolerability and PK/PD clinical trial in subjects with IPF (see NCT02738801). | View clinical data
Bioactivity Comments: GLPG1690 produces a sustained decrease in plasma LPA levels in vivo and this results in reduced extracellular matrix deposition in the lung tissue of mice with bleomycin-induced pulmonary fibrosis [3] | View biological activity
PBI-4050
Immuno Disease Comments: Phase 2 clinical candidate for IPF- see NCT02538536
Clinical Use: PBI-4050 has reached Phase 2 clinical evaluation in a variety of inflammatory and fibrotic conditions. Click here to link to the complete list of PBI-4050 trials registered with ClinicalTrials.gov. | View clinical data

References

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1. Adams B. Sanofi ditches IL-4/IL-13 antibody drug in lung-scarring disease. Accessed on 09/02/2018. Modified on 09/02/2018. fiercebiotech.com, https://www.fiercebiotech.com/biotech/sanofi-ditches-il4-il13-antibody-drug-lung-scarring-disease

2. Corren J, Lemanske RF, Hanania NA, Korenblat PE, Parsey MV, Arron JR, Harris JM, Scheerens H, Wu LC, Su Z et al.. (2011) Lebrikizumab treatment in adults with asthma. N. Engl. J. Med., 365 (12): 1088-98. [PMID:21812663]

3. Desroy N, Housseman C, Bock X, Joncour A, Bienvenu N, Cherel L, Labeguere V, Rondet E, Peixoto C, Grassot JM et al.. (2017) Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis. J. Med. Chem., 60 (9): 3580-3590. [PMID:28414242]

4. Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S et al.. (2013) Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat. Genet., 45 (6): 613-20. [PMID:23583980]

5. Fung SC, Moyle M. (2010) Treatment of Interleukin13 dependent neoplastic disorders. Patent number: US7674459. Assignee: Genentech, Inc.. Priority date: 23/12/2003. Publication date: 09/03/2010.

6. King Jr TE, Bradford WZ, Castro-Bernardini S, Fagan EA, Glaspole I, Glassberg MK, Gorina E, Hopkins PM, Kardatzke D, Lancaster L et al.. (2014) A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N. Engl. J. Med., 370 (22): 2083-92. [PMID:24836312]

7. Scheerens H, Arron JR, Zheng Y, Putnam WS, Erickson RW, Choy DF, Harris JM, Lee J, Jarjour NN, Matthews JG. (2014) The effects of lebrikizumab in patients with mild asthma following whole lung allergen challenge. Clin. Exp. Allergy, 44 (1): 38-46. [PMID:24131304]