pirfenidone

Ligand id: 7532

Name: pirfenidone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 20.31
Molecular weight 185.08
XLogP 3.34
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved to treat idiopathic pulmonary fibrosis (IPF) [3].
Mechanism Of Action and Pharmacodynamic Effects
The precise molecular mechanism of action of this drug is not fully resolved, but may involve a reduction in the production of fibroblasts and pro-fibrogenic substances in the lungs of IPF patients [1], thus slowing disease progression.
External links