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Robinow syndrome, autosomal recessive

Disease ID:832
Name:Robinow syndrome, autosomal recessive
Associated with:1 target
1 immuno-relevant ligand
Database Links
OMIM: 268310
Orphanet: ORPHA1507


receptor tyrosine kinase like orphan receptor 2


Key to terms and symbols Click ligand name to view ligand summary Click column headers to sort
Ligand References Clinical and Disease comments
Immuno Disease Comments: An approved gold-containing complex with antirheumatic activity.
Clinical Use: Auranofin is a gold-containing medicine used for the management of rheumatoid arthritis in patients who do not respond to or are intolerant of other medicines. | View clinical data
Bioactivity Comments: Auranofin inhibits thioredoxin reductase isolated from human placenta, with a Ki of 4nM [1]. | View biological activity


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1. Gromer S, Arscott LD, Williams Jr CH, Schirmer RH, Becker K. (1998) Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds. J. Biol. Chem., 273 (32): 20096-101. [PMID:9685351]