SLC2 family of hexose and sugar alcohol transporters

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLC2 family transports D-glucose, D-fructose, inositol (e.g. myo-inositol) and related hexoses. Three classes of glucose transporter can be identified, separating GLUT1-4 and 14, GLUT6, 8, 10 and 12; and GLUT5, 7, 9 and 11. Modelling suggests a 12 TM membrane topology, with intracellular termini, with functional transporters acting as homodimers or homotetramers.

Class I transporters

Overview

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Class I transporters are able to transport D-glucose, but not D-fructose, in the direction of the concentration gradient and may be inhibited non-selectively by phloretin and cytochalasin B. GLUT1 is the major glucose transporter in brain, placenta and erythrocytes, GLUT2 is found in the pancreas, liver and kidneys, GLUT3 is neuronal and placental, while GLUT4 is the insulin-responsive transporter found in skeletal muscle, heart and adipose tissue. GLUT14 appears to result from gene duplication of GLUT3 and is expressed in the testes [12].

Transporters

GLUT1 (Glucose transporter 1 / SLC2A1) Show summary »

GLUT2 (Glucose transporter 2 / SLC2A2) Show summary »

GLUT3 (Glucose transporter 3 / SLC2A3) Show summary »

GLUT4 (Glucose transporter 4 / SLC2A4) Show summary »

GLUT14 (Glucose transporter 14 / SLC2A14) Show summary »

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Class II transporters

Overview

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Class II transporters transport D-fructose and appear to be insensitive to cytochalasin B. Class II transporters appear to be predominantly intracellularly located.

Transporters

GLUT5 (Glucose transporter 5 / SLC2A5) Show summary »

GLUT7 (Glucose transporter 7 / SLC2A7) Show summary »

GLUT9 (Glucose transporter 9 / SLC2A9) Show summary »

GLUT11 (Glucose transporter 11 / SLC2A11) Show summary »

GLUT6 (Glucose transporter 6 / SLC2A6) Show summary »

GLUT8 (Glucose transporter 8 / SLC2A8) Show summary »

GLUT10 (Glucose transporter 10 / SLC2A10) Show summary »

GLUT12 (Glucose transporter 12 / SLC2A12) Show summary »

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Proton-coupled inositol transporter

Overview

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Proton-coupled inositol transporters are expressed predominantly in the brain and can be inhibited by phloretin and cytochalasin B [11].

Transporters

HMIT (Proton myo-inositol cotransporter / SLC2A13) Show summary »

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Further reading

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References

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