Class I transporters

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Class I transporters are able to transport D-glucose, but not D-fructose, in the direction of the concentration gradient and may be inhibited non-selectively by phloretin and cytochalasin B. GLUT1 is the major glucose transporter in brain, placenta and erythrocytes, GLUT2 is found in the pancreas, liver and kidneys, GLUT3 is neuronal and placental, while GLUT4 is the insulin-responsive transporter found in skeletal muscle, heart and adipose tissue. GLUT14 appears to result from gene duplication of GLUT3 and is expressed in the testes [3].


GLUT1 (Glucose transporter 1 / SLC2A1) Show summary » More detailed page

GLUT2 (Glucose transporter 2 / SLC2A2) Show summary »

GLUT3 (Glucose transporter 3 / SLC2A3) Show summary »

GLUT4 (Glucose transporter 4 / SLC2A4) Show summary »

GLUT14 (Glucose transporter 14 / SLC2A14) Show summary »


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How to cite this family page

Database page citation:

Class I transporters. Accessed on 29/03/2015. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Transporters. Br J Pharmacol. 170: 1706–1796.