SLC10 family of sodium-bile acid co-transporters
The SLC10 family transport bile acids and their derivatives in a sodium-dependent manner. Along with members of the ABC transporter family (MDR1/ABCB1; BSEP/ABCB11; and MRP2/ABCC2) and the organic solute transporter obligate heterodimer OSTα:OSTβ, these transporters allow enterohepatic circulation of bile acids [4,13].
The SLC10 family appear to be monomeric with external N-termini and cytoplasmic C-termini and seven TM segments [1,11].
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters 
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Sodium/bile acid cotransporter 1 (SLC10A1) Show »« Hide
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Sodium/bile acid cotransporter 2 (SLC10A2) Show »« Hide
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Sodium/bile acid cotransporter 3 (SLC10A3) Show »« Hide
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Sodium/bile acid cotransporter 4 (SLC10A4) Show »« Hide
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Sodium/bile acid cotransporter 5 (SLC10A5) Show »« Hide
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Sodium/bile acid cotransporter 6 (SLC10A6) Show »« Hide
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Sodium/bile acid cotransporter 7 (SLC10A7) Show »« Hide
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Alrefai, WA; Gill, RK. (2007) Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm. Res., 24 (10): 1803-23. [PMID:17404808]
Dawson, PA; Lan, T; Rao, A. (2009) Bile acid transporters. J. Lipid Res., 50 (12): 2340-57. [PMID:19498215]
Geyer, J; Wilke, T; Petzinger, E. (2006) The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. Naunyn Schmiedebergs Arch. Pharmacol., 372 (6): 413-31. [PMID:16541252]
Hagenbuch, B; Dawson, P. (2004) The sodium bile salt cotransport family SLC10. Pflugers Arch., 447 (5): 566-70. [PMID:12851823]
Klaassen, CD; Aleksunes, LM. (2010) Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol. Rev., 62 (1): 1-96. [PMID:20103563]
Kosters, A; Karpen, SJ. (2008) Bile acid transporters in health and disease. Xenobiotica, 38 (7-8): 1043-71. [PMID:18668439]
1. Banerjee, A; Swaan, PW. (2006) Membrane topology of human ASBT (SLC10A2) determined by dual label epitope insertion scanning mutagenesis. New evidence for seven transmembrane domains. Biochemistry, 45 (3): 943-53. [PMID:16411770]
2. Burger, S; Döring, B; Hardt, M; Beuerlein, K; Gerstberger, R; Geyer, J. (2011) Co-expression studies of the orphan carrier protein Slc10a4 and the vesicular carriers VAChT and VMAT2 in the rat central and peripheral nervous system. Neuroscience, 193: 109-21. [PMID:21742018]
3. Craddock, AL; Love, MW; Daniel, RW; Kirby, LC; Walters, HC; Wong, MH; Dawson, PA. (1998) Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am. J. Physiol., 274 (1 Pt 1): G157-69. [PMID:9458785]
4. Dawson, PA; Lan, T; Rao, A. (2009) Bile acid transporters. J. Lipid Res., 50 (12): 2340-57. [PMID:19498215]
5. Friesema, EC; Docter, R; Moerings, EP; Stieger, B; Hagenbuch, B; Meier, PJ; Krenning, EP; Hennemann, G; Visser, TJ. (1999) Identification of thyroid hormone transporters. Biochem. Biophys. Res. Commun., 254 (2): 497-501. [PMID:9918867]
6. Geyer, J; Döring, B; Meerkamp, K; Ugele, B; Bakhiya, N; Fernandes, CF; Godoy, JR; Glatt, H; Petzinger, E. (2007) Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). J. Biol. Chem., 282 (27): 19728-41. [PMID:17491011]
7. Geyer, J; Fernandes, CF; Döring, B; Burger, S; Godoy, JR; Rafalzik, S; Hübschle, T; Gerstberger, R; Petzinger, E. (2008) Cloning and molecular characterization of the orphan carrier protein Slc10a4: expression in cholinergic neurons of the rat central nervous system. Neuroscience, 152 (4): 990-1005. [PMID:18355966]
8. Geyer, J; Godoy, JR; Petzinger, E. (2004) Identification of a sodium-dependent organic anion transporter from rat adrenal gland. Biochem. Biophys. Res. Commun., 316 (2): 300-6. [PMID:15020217]
9. Godoy, JR; Fernandes, C; Döring, B; Beuerlein, K; Petzinger, E; Geyer, J. (2007) Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria. Eur. J. Cell Biol., 86 (8): 445-60. [PMID:17628207]
10. Hagenbuch, B; Meier, PJ. (1996) Sinusoidal (basolateral) bile salt uptake systems of hepatocytes. Semin. Liver Dis., 16 (2): 129-36. [PMID:8781018]
11. Hallén, S; Brändén, M; Dawson, PA; Sachs, G. (1999) Membrane insertion scanning of the human ileal sodium/bile acid co-transporter. Biochemistry, 38 (35): 11379-88. [PMID:10471288]
12. Kim, RB; Leake, B; Cvetkovic, M; Roden, MM; Nadeau, J; Walubo, A; Wilkinson, GR. (1999) Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity. J. Pharmacol. Exp. Ther., 291 (3): 1204-9. [PMID:10565843]
13. Klaassen, CD; Aleksunes, LM. (2010) Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol. Rev., 62 (1): 1-96. [PMID:20103563]
14. Meier, PJ; Eckhardt, U; Schroeder, A; Hagenbuch, B; Stieger, B. (1997) Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology, 26 (6): 1667-77. [PMID:9398014]
15. Visser, WE; Wong, WS; van Mullem, AA; Friesema, EC; Geyer, J; Visser, TJ. (2010) Study of the transport of thyroid hormone by transporters of the SLC10 family. Mol. Cell. Endocrinol., 315 (1-2): 138-45. [PMID:19682536]
16. Weinman, SA. (1997) Electrogenicity of Na(+)-coupled bile acid transporters. Yale J Biol Med, 70 (4): 331-40. [PMID:9626753]
17. Weinman, SA; Carruth, MW; Dawson, PA. (1998) Bile acid uptake via the human apical sodium-bile acid cotransporter is electrogenic. J. Biol. Chem., 273 (52): 34691-5. [PMID:9856990]
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Heterologously expressed SLC10A4 [7] or SLC10A7 [9] failed to exhibit significant transport of TCA, pregnenolone sulphate, DHEAS or choline. SLC10A4 has recently been suggested to associate with neuronal vesicles [2].