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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The SLC34 family are sometimes referred to as Type II sodium-phosphate co-transporters, alongside Type I (SLC17 family) and Type III (SLC20 family) transporters. Topological modelling suggests eight TM domains with C- and N- termini in the cytoplasm, and a re-entrant loop at TM7/8. SLC34 family members are expressed on the apical surfaces of epithelia in the intestine and kidneys to regulate body phosphate levels, principally NaPi-IIa and NaPi-IIb, respectively. NaPi-IIa and NaPi-IIb are electrogenic, while NaPiIIc is electroneutral .
* Key recommended reading is highlighted with an asterisk
* Biber J, Hernando N, Forster I. (2013) Phosphate transporters and their function. Annu. Rev. Physiol., 75: 535-50. [PMID:23398154]
* Forster IC, Hernando N, Biber J, Murer H. (2013) Phosphate transporters of the SLC20 and SLC34 families. Mol. Aspects Med., 34 (2-3): 386-95. [PMID:23506879]
* Marks J, Debnam ES, Unwin RJ. (2010) Phosphate homeostasis and the renal-gastrointestinal axis. Am. J. Physiol. Renal Physiol., 299 (2): F285-96. [PMID:20534868]
* Miyamoto K, Haito-Sugino S, Kuwahara S, Ohi A, Nomura K, Ito M, Kuwahata M, Kido S, Tatsumi S, Kaneko I et al.. (2011) Sodium-dependent phosphate cotransporters: lessons from gene knockout and mutation studies. J Pharm Sci, 100 (9): 3719-30. [PMID:21567407]
* Murer H, Forster I, Biber J. (2004) The sodium phosphate cotransporter family SLC34. Pflugers Arch., 447 (5): 763-7. [PMID:12750889]
* Shobeiri N, Adams MA, Holden RM. (2013) Phosphate: an old bone molecule but new cardiovascular risk factor. Br J Clin Pharmacol, [Epub ahead of print]. [PMID:23506202]
* Wagner CA, Hernando N, Forster IC, Biber J. (2014) The SLC34 family of sodium-dependent phosphate transporters. Pflugers Arch., 466 (1): 139-53. [PMID:24352629]
1. Andrini O, Ghezzi C, Murer H, Forster IC. (2008) The leak mode of type II Na(+)-P(i) cotransporters. Channels (Austin), 2 (5): 346-57. [PMID:18989094]
2. Dennis M, Rubinfeld B, Polakis P. (2013) Compositions and methods for the diagnosis and treatment of tumor. Patent number: US8535675 B2. Assignee: Genentech, Inc.. Priority date: 30/11/2009. Publication date: 17/09/2013.
3. Forster IC, Loo DD, Eskandari S. (1999) Stoichiometry and Na+ binding cooperativity of rat and flounder renal type II Na+-Pi cotransporters. Am. J. Physiol., 276 (4 Pt 2): F644-9. [PMID:10198426]
Database page citation:
SLC34 family of sodium phosphate co-transporters. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=221.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.