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The SLC34 family are sometimes referred to as Type II sodium-phosphate co-transporters, alongside Type I (SLC17 family) and Type III (SLC20 family) transporters. Topological modelling suggests eight TM domains with C- and N- termini in the cytoplasm, and a re-entrant loop at TM5/6. SLC34 family members are expressed on the apical surfaces of epithelia in the intestine and kidneys to regulate body phosphate levels, principally NaPi-IIa and NaPi-IIb, respectively. NaPi-IIa and NaPi-IIb are electrogenic, while NaPiIIc is electrogenic .
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Sodium phosphate 1 (SLC34A1) Show »
Sodium phosphate 2 (SLC34A2) Show »
Sodium phosphate 3 (SLC34A3) Show »
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Further Reading Show »
Murer, H; Forster, I; Biber, J. (2004) The sodium phosphate cotransporter family SLC34. Pflugers Arch., 447 (5): 763-7. [PMID:12750889]
References Show »
1. Andrini, O; Ghezzi, C; Murer, H; Forster, IC. (2008) The leak mode of type II Na(+)-P(i) cotransporters. Channels (Austin), 2 (5): 346-57. [PMID:18989094]
2. Forster, IC; Loo, DD; Eskandari, S. (1999) Stoichiometry and Na+ binding cooperativity of rat and flounder renal type II Na+-Pi cotransporters. Am. J. Physiol., 276 (4 Pt 2): F644-9. [PMID:10198426]