BPS/IUPHAR Guide to Pharmacology | GRAC ENZYME FAMILIES

Protein turnover

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Aminopeptidases
Serine-type carboxypeptidases
Metallocarboxypeptidases
Endopeptidases
Caspases
Cell-surface protein and extracellular matrix metalloproteinases
ADAM
ADAMTS family

Peptidases and proteinases hydrolyse peptide bonds, and can be simply divided on the basis of whether terminal peptide bonds are cleaved (exopeptidases and exoproteinases) at the amino terminus (aminopeptidases) or carboxy terminus (carboxypeptidases). Non-terminal peptide bonds are cleaved by endopeptidases and endoproteinases, which are divided into serine endopeptidases (EC 3.4.21.-), cysteine endopeptidases (EC 3.4.22.-), aspartate endopeptidases (EC 3.4.23.-), metalloendopeptidases (EC 3.4.24.-) and threonine endopeptidases (EC 3.4.25.-).

It is beyond the scope of the Guide to list all peptidase and proteinase activities; this summary focuses on selected enzymes of significant pharmacological interest.

Aminopeptidases

Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Aminopeptidase A Show »« Hide

Aminopeptidase N Show »« Hide

Nomenclature	Aminopeptidase N
Other names	Alanyl aminopeptidase, microsomal aminopeptidase, gp150, myeloid plasma membrane glycoprotein CD13, CD13, PEPN, LAP1, p150, aminopeptidase N, aminopeptidase M, AP-M, AP-N, APN, Apm, KZP, rAPN, cluster of differentiation antigen 13 (CD13), kidney Zn peptidase, kidney aminopeptidase M, leucine arylaminopeptidase 1, membrane alanine aminopeptidase
Genes	ANPEP (Hs), Anpep (Mm), Anpep (Rn)
Ensembl ID	ENSG00000166825 (Hs), ENSMUSG00000039062 (Mm), ENSRNOG00000014610 (Rn)

Aminopeptidase O Show »« Hide

Nomenclature	Aminopeptidase O
Other names	AOPEP
Ensembl ID	ENSG00000148120 (Hs)

Aminopeptidase Q Show »« Hide

Nomenclature	Aminopeptidase Q
Other names	Laeverin, AC010282.1
Ensembl ID	ENSG00000172901 (Hs)

Aminopeptidase-like 1 Show »« Hide

Nomenclature	Aminopeptidase-like 1
Other names	FLJ11583, bA261P9.2, LOC311671, Npepl1_predicted, aminopeptidase-like 1, aminopeptidase-like 1 (predicted), probable aminopeptidase NPEPL1
Genes	NPEPL1 (Hs), Npepl1 (Mm), Npepl1 (Rn)
Ensembl ID	ENSG00000215440 (Hs), ENSMUSG00000039263 (Mm), ENSRNOG00000028384 (Rn)

Arginyl aminopeptidase Show »« Hide

Arginyl aminopeptidase-like 1 Show »« Hide

Endoplasmic reticulum aminopeptidase 1 Show »« Hide

Nomenclature	Endoplasmic reticulum aminopeptidase 1
Other names	Adipocyte-derived leucine aminopeptidase, puromycin-insensitive leucyl-specific aminopeptidase, type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, ARTS-1, A-LAP, PILS-AP, KIAA0525, ERAAP1, aminopeptidase regulator of TNFR1 shedding, Appils, Arts1, MGC112613, ER-aminopeptidase 1, aminopeptidase PILS, endoplasmic reticulum aminopeptidase 1, leucyl-specific aminopeptidase PILS, PILSAP, ERAAP
Genes	ERAP1 (Hs), Erap1 (Mm), Erap1 (Rn)
Ensembl ID	ENSG00000164307 (Hs), ENSMUSG00000021583 (Mm), ENSRNOG00000009997 (Rn)

Endoplasmic reticulum aminopeptidase 2 Show »« Hide

Nomenclature	Endoplasmic reticulum aminopeptidase 2
Other names	Leukocyte-derived arginine aminopeptidase, L-RAP, LRAP
Genes	ERAP2 (Hs)
Ensembl ID	ENSG00000164308 (Hs)

Glutamyl aminopeptidase Show »« Hide

Nomenclature	Glutamyl aminopeptidase
Other names	EAP, aminopeptidase A, differentiation antigen gp160, CD249 antigen, gp160, CD249, AP-A, glutamyl aminopeptidase, Bp-1/6C3, APA, Ly-51, Ly51, aminopeptidase-A
Genes	ENPEP (Hs), Enpep (Mm), Enpep (Rn)
Ensembl ID	ENSG00000138792 (Hs), ENSMUSG00000028024 (Mm), ENSRNOG00000030121 (Rn)

Leucine aminopeptidase 3 Show »« Hide

Nomenclature	Leucine aminopeptidase 3
Other names	LAP, LAPEP, PEPS, peptidase S, LAP-3, LOC289668, Lap3_predicted, cytosol aminopeptidase, leucine aminopeptidase 3, leucine aminopeptidase 3 (predicted), leucyl aminopeptidase, proline aminopeptidase, prolyl aminopeptidase, Pep-S, Pep-7, Pep7
Genes	LAP3 (Hs), Lap3 (Mm), Lap3 (Rn)
Ensembl ID	ENSG00000002549 (Hs), ENSMUSG00000039682 (Mm), ENSRNOG00000003289 (Rn)

Leucyl-cysteinyl aminopeptidase Show »« Hide

Nomenclature	Leucyl-cysteinyl aminopeptidase
Other names	Oxytocinase, Otase, insulin-regulated membrane aminopeptidase, insulin-responsive aminopeptidase, IRAP, placental leucine aminopeptidase, P-LAP, CAP, PLAP, cystinyl aminopeptidase, Vp165, GP160, aminopeptidase Vp165, angiotensin IV receptor, insulin-regulated membrane aminopeptidase IRAP, leucyl-cystinyl aminopeptidase, vesicle protein of 165 kDa
Genes	LNPEP (Hs), Lnpep (Mm), Lnpep (Rn)
Ensembl ID	ENSG00000113441 (Hs), ENSMUSG00000023845 (Mm), ENSRNOG00000013082 (Rn)
Comment	Hydrolyses AVP, oxytocin, kallidin, [Met]enkephalin, dynorphin A

Leukotriene A4 hydrolase Show »« Hide

Nomenclature	Leukotriene A4 hydrolase
Other names	-
Genes	LTA4H (Hs)
Ensembl ID	ENSG00000111144 (Hs)
Comment	Hydrolyses LTA₄

Methionyl aminopeptidase 1 Show »« Hide

Nomenclature	Methionyl aminopeptidase 1
Other names	MAP1A, KIAA0094, MetAP1A, Peptidase M, LOC295500, Metap1_predicted, methionine aminopeptidase 1, methionyl aminopeptidase 1, methionyl aminopeptidase 1 (predicted)
Genes	METAP1 (Hs), Metap1 (Mm), Metap1 (Rn)
Ensembl ID	ENSG00000164024 (Hs), ENSMUSG00000005813 (Mm), ENSRNOG00000012947 (Rn)

Methionyl aminopeptidase 2 Show »« Hide

Nomenclature	Methionyl aminopeptidase 2
Other names	MNPEP, p67, MAP2, Peptidase M, Amp2, MAP 2, initiation factor 2 associated 67 kDa protein, initiation factor 2-associated 67 kDa glycoprotein, metAP 2, methionine aminopeptidase, methionine aminopeptidase 2, methionyl aminopeptidase 2, p67eIF2, peptidase M 2, eIF-2-associated p67
Genes	METAP2 (Hs), Metap2 (Mm), Metap2 (Rn)
Ensembl ID	ENSG00000111142 (Hs), ENSMUSG00000036112 (Mm), ENSRNOG00000021881 (Rn)

Methionyl aminopeptidase type 1D (mitochondrial) Show »« Hide

Nomenclature	Methionyl aminopeptidase type 1D (mitochondrial)
Other names	MAP1D, Metap1l, methionine aminopeptidase 1D, LOC311748, Metapl1, Metapl1_predicted, methionine aminopeptidase 1D, mitochondrial, methionine aminopeptidase-like 1, methionine aminopeptidase-like 1 (predicted)
Genes	METAP1D (Hs), Metap1d (Mm), Metap1d (Rn)
Ensembl ID	ENSG00000172878 (Hs), ENSMUSG00000041921 (Mm), ENSRNOG00000001522 (Rn)

Puromycin-sensitive aminopeptidase Show »« Hide

Nomenclature	Puromycin-sensitive aminopeptidase
Other names	Aminopeptidase puromycin sensitive, PSA, MP100, puromycin-sensitive aminopeptidase, metalloproteinase MP100
Genes	NPEPPS (Hs), Npepps (Mm), Npepps (Rn)
Ensembl ID	ENSG00000141279 (Hs), ENSMUSG00000001441 (Mm), ENSRNOG00000023095 (Rn)

Puromycin-sensitive aminopeptidase-like protein Show »« Hide

Nomenclature	Puromycin-sensitive aminopeptidase-like protein
Other names	RP11-1407O15.2
Ensembl ID	ENSG00000174093 (Hs)

TRH-specific aminopeptidase Show »« Hide

Nomenclature	TRH-specific aminopeptidase
Other names	Thyrotropin-releasing hormone-degrading ectoenzyme, thyroliberinase, pyroglutamyl-peptidase II, PAP-II, PGPEP2, TRH-DE, pyroglutamyl aminopeptidase II, TRH-degrading ectoenzyme, thyrotropin-releasing hormone degrading ectoenzyme, thyrotropin-releasing hormone degrading enzyme
Genes	TRHDE (Hs), Trhde (Mm), Trhde (Rn)
Ensembl ID	ENSG00000072657 (Hs), ENSMUSG00000050663 (Mm), ENSRNOG00000005278 (Rn)

X-prolyl aminopeptidase 1 Show »« Hide

Nomenclature	X-prolyl aminopeptidase 1
Other names	Aminopeptidase P 1, soluble X-prolyl aminopeptidase, XPNPEP, XPNPEPL1, XPNPEPL, X-prolyl aminopeptidase (aminopeptidase P)-like, X-Pro aminopeptidase 1, soluble, X-prolyl aminopeptidase 1, soluble, aminoacylproline aminopeptidase, cytoplasmic aminopeptidase P, cytosolic aminopeptidase P, sAmp, soluble aminopeptidase P, xaa-Pro aminopeptidase 1
Genes	XPNPEP1 (Hs), Xpnpep1 (Mm), Xpnpep1 (Rn)
Ensembl ID	ENSG00000108039 (Hs), ENSMUSG00000025027 (Mm), ENSRNOG00000012084 (Rn)

X-prolyl aminopeptidase 2 Show »« Hide

Nomenclature	X-prolyl aminopeptidase 2
Other names	Aminopeptidase P 2, membrane-bound X-prolyl aminopeptidase, X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound, xaa-Pro aminopeptidase 2, mAPP
Genes	XPNPEP2 (Hs), Xpnpep2 (Mm), Xpnpep2 (Rn)
Ensembl ID	ENSG00000122121 (Hs), ENSMUSG00000037005 (Mm), ENSRNOG00000004009 (Rn)

X-prolyl aminopeptidase 3 Show »« Hide

Nomenclature	X-prolyl aminopeptidase 3
Other names	Aminopeptidase P 3, APP3, NPHPL1, LOC685823, MGC188876, X-Pro aminopeptidase 3, X-prolyl aminopeptidase (aminopeptidase P) 3, putative, aminopeptidase P3, probable Xaa-Pro aminopeptidase 3, similar to CG9581-PA
Genes	XPNPEP3 (Hs), Xpnpep3 (Mm), Xpnpep3 (Rn)
Ensembl ID	ENSG00000196236 (Hs), ENSMUSG00000022401 (Mm), ENSRNOG00000019196 (Rn)

Serine-type carboxypeptidases

Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Cathepsin A Show »« Hide

Nomenclature	Cathepsin A
Other names	GSL, PPGB, carboxypeptidase C, protective protein for beta-galactosidase (galactosialidosis), lysosomal protective protein, carboxypeptidase-L, carboxypeptidase Y-like kininase, deamidase, lysosomal carboxypeptidase A, urinary kininase, LOC296370, Ppgb_predicted, cathepsin A, protective protein for beta-galactosidase, protective protein for beta-galactosidase (predicted), PPCA
Genes	CTSA (Hs), Ctsa (Mm), Ctsa (Rn)
Ensembl ID	ENSG00000064601 (Hs), ENSMUSG00000017760 (Mm), ENSRNOG00000015857 (Rn)

Carboxypeptidase D Show »« Hide

Vitellogenic carboxypeptidase-like protein Show »« Hide

Nomenclature	Vitellogenic carboxypeptidase-like protein
Other names	carboxypeptidase WUG, vitellogenic carboxypeptidase-like protein, CP-Mac carboxypeptidase, LOC502774, MGC114536, carboxypeptidase, vitellogenic-like, probable serine carboxypeptidase CPVL, VCP-like protein, similar to Probable serine carboxypeptidase CPVL precursor
Genes	CPVL (Hs), Cpvl (Mm), Cpvl (Rn)
Ensembl ID	ENSG00000106066 (Hs), ENSMUSG00000052955 (Mm), ENSRNOG00000009172 (Rn)

Prolylcarboxypeptidase Show »« Hide

Nomenclature	Prolylcarboxypeptidase
Other names	Angiotensinase C, HUMPCP, PCP, lysosomal Pro-X carboxypeptidase, LOC293118, Prcp_predicted, prolylcarboxypeptidase, prolylcarboxypeptidase (angiotensinase C) (predicted)
Genes	PRCP (Hs), Prcp (Mm), Prcp (Rn)
Ensembl ID	ENSG00000137509 (Hs), ENSMUSG00000061119 (Mm), ENSRNOG00000010630 (Rn)

Serine carboxypeptidase 1 Show »« Hide

Nomenclature	Serine carboxypeptidase 1
Other names	RISC, retinoid inducible serine carboxypeptidase, retinoid-inducible serine carboxypeptidase, serine carboxypeptidase 1
Genes	SCPEP1 (Hs), Scpep1 (Mm), Scpep1 (Rn)
Ensembl ID	ENSG00000121064 (Hs), ENSMUSG00000000278 (Mm), ENSRNOG00000002358 (Rn)

Metallocarboxypeptidases

Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

AE binding protein 1 Show »« Hide

Nomenclature	AE binding protein 1
Other names	Aortic carboxypeptidase-like protein ACLP, ACLP, AE-binding protein 1, aortic carboxypeptidase-like protein, adipocyte enhancer binding protein 1, Aebp1_predicted, LOC305494, AE binding protein 1 (predicted), adipocyte enhancer-binding protein 1
Genes	AEBP1 (Hs), Aebp1 (Mm), Aebp1 (Rn)
Ensembl ID	ENSG00000106624 (Hs), ENSMUSG00000020473 (Mm), ENSRNOG00000013720 (Rn)

Carboxypeptidase A1 (pancreatic) Show »« Hide

Carboxypeptidase A2 (pancreatic) Show »« Hide

Nomenclature	Carboxypeptidase A2 (pancreatic)
Other names	CPA2, Cpa2_mapped, Cpa2_predicted, LOC296959, carboxypeptidase A2, carboxypeptidase A2 (mapped), carboxypeptidase A2 (pancreatic) (predicted)
Genes	CPA2 (Hs), Cpa2 (Mm), Cpa2 (Rn)
Ensembl ID	ENSG00000158516 (Hs), ENSMUSG00000071553 (Mm), ENSRNOG00000028092 (Rn)

Carboxypeptidase A3 (mast cell) Show »« Hide

Nomenclature	Carboxypeptidase A3 (mast cell)
Other names	mast cell carboxypeptidase A, tissue carboxypeptidase A, R-CPA, RMC-CP, carboxypeptidase A3, carboxypeptidase A3 mast cell, carboxypeptidase A3, mast cell, mMC-CPA, MC-CPA
Genes	CPA3 (Hs), Cpa3 (Mm), Cpa3 (Rn)
Ensembl ID	ENSG00000163751 (Hs), ENSMUSG00000001865 (Mm), ENSRNOG00000011181 (Rn)

Carboxypeptidase A4 Show »« Hide

Nomenclature	Carboxypeptidase A4
Other names	CPA3, carboxypeptidase A3, LOC502736, RGD1563619, RGD1563619_predicted, carboxypeptidase A4, similar to carboxypeptidase A4, similar to carboxypeptidase A4 (predicted)
Genes	CPA4 (Hs), Cpa4 (Mm), Cpa4 (Rn)
Ensembl ID	ENSG00000128510 (Hs), ENSMUSG00000039070 (Mm), ENSRNOG00000010463 (Rn)

Carboxypeptidase A5 Show »« Hide

Carboxypeptidase A6 Show »« Hide

Carboxypeptidase B1 (tissue) Show »« Hide

Nomenclature	Carboxypeptidase B1 (tissue)
Other names	pancreatic carboxypeptidase B, tissue carboxypeptidase B, protaminase, Cpb, Carboxypeptidase B, carboxypeptidase B1, pancreatic carboxypeptidase B1
Genes	CPB1 (Hs), Cpb1 (Mm), Cpb1 (Rn)
Ensembl ID	ENSG00000153002 (Hs), ENSMUSG00000011463 (Mm), ENSRNOG00000030904 (Rn)

Carboxypeptidase B2 (plasma) Show »« Hide

Nomenclature	Carboxypeptidase B2 (plasma)
Other names	CPU, PCPB, TAFI, carboxypeptidase B2 (plasma, carboxypeptidase U), thrombin-activatable fibrinolysis inhibitor, carboxypeptidase U, plasma carboxypeptidase B, carboxypeptidase R, CPR, carboxypeptidase B2
Genes	CPB2 (Hs), Cpb2 (Mm), Cpb2 (Rn)
Ensembl ID	ENSG00000080618 (Hs), ENSMUSG00000021999 (Mm), ENSRNOG00000010935 (Rn)

Carboxypeptidase E Show »« Hide

Nomenclature	Carboxypeptidase E
Other names	carboxypeptidase H, enkephalin convertase, insulin granule-associated carboxypeptidase, cobalt-stimulated chromaffin granule carboxypeptidase, CARBE, Cph, MGC93638, carboxypeptidase E, prohormone-processing carboxypeptidase, Cph-1, Cph1
Genes	CPE (Hs), Cpe (Mm), Cpe (Rn)
Ensembl ID	ENSG00000109472 (Hs), ENSMUSG00000037852 (Mm), ENSRNOG00000043387 (Rn)

Carboxypeptidase M Show »« Hide

Nomenclature	Carboxypeptidase M
Other names	renal carboxypeptidase, urinary carboxypeptidase B, Cpm_predicted, LOC314855, carboxypeptidase M, carboxypeptidase M (predicted)
Genes	CPM (Hs), Cpm (Mm), Cpm (Rn)
Ensembl ID	ENSG00000135678 (Hs), ENSMUSG00000020183 (Mm), ENSRNOG00000034134 (Rn)

Carboxypeptidase N, polypeptide 1 Show »« Hide

Nomenclature	Carboxypeptidase N, polypeptide 1
Other names	Carboxypeptidase N, polypeptide 1, carboxypeptidase N, polypeptide 1, 50kD, anaphylatoxin inactivator, arginine carboxypeptidase, carboxypeptidase K, kininase I, lysine carboxypeptidase, Cpn, MGC108636, carboxypeptidase N catalytic chain, carboxypeptidase N catalytic chain-like, carboxypeptidase N small subunit, carboxypeptidase N, polypeptide 1, 50 kDa
Genes	CPN1 (Hs), Cpn1 (Mm), Cpn1 (Rn)
Ensembl ID	ENSG00000120054 (Hs), ENSMUSG00000025196 (Mm), ENSRNOG00000013439 (Rn)

Carboxypeptidase N, polypeptide 2 Show »« Hide

Nomenclature	Carboxypeptidase N, polypeptide 2
Other names	ACBP, carboxypeptidase N, polypeptide 2, 83kD, LOC303861_predicted, RGD1305170, RGD1305170_predicted, carboxypeptidase N subunit 2, carboxypeptidase N, polypeptide 2, similar to Carboxypeptidase N 83 kDa chain (Carboxypeptidase N regulatory subunit) (predicted)
Genes	CPN2 (Hs), Cpn2 (Mm), Cpn2 (Rn)
Ensembl ID	ENSG00000178772 (Hs), ENSMUSG00000023176 (Mm), ENSRNOG00000024384 (Rn)

Carboxypeptidase O Show »« Hide

Nomenclature	Carboxypeptidase O
Other names	metallocarboxypeptidase O, metallocarboxypeptidase C
Genes	CPO (Hs)
Ensembl ID	ENSG00000144410 (Hs)

Carboxypeptidase X (M14 family), member 1 Show »« Hide

Nomenclature	Carboxypeptidase X (M14 family), member 1
Other names	CPX-1, CPX1, CPXM, carboxypeptidase X (M14 family), carboxypeptidase-like protein X1, Cpxm1_predicted, LOC296156, carboxypeptidase X (M14 family), member 1, carboxypeptidase X 1 (M14 family), carboxypeptidase X 1 (M14 family) (predicted), probable carboxypeptidase X1
Genes	CPXM1 (Hs), Cpxm1 (Mm), Cpxm1 (Rn)
Ensembl ID	ENSG00000088882 (Hs), ENSMUSG00000027408 (Mm), ENSRNOG00000021220 (Rn)

Carboxypeptidase X (M14 family), member 2 Show »« Hide

Nomenclature	Carboxypeptidase X (M14 family), member 2
Other names	UNQ676, CPX2, cytosolic carboxypeptidase, RGD1310955_predicted, Cpxm2_predicted, LOC293566_predicted, RGD1310955, carboxypeptidase X (M14 family), member 2, carboxypeptidase X 2 (M14 family), carboxypeptidase X 2 (M14 family) (predicted), carboxypeptidase X2, inactive carboxypeptidase-like protein X2, metallocarboxypeptidase 2, similar to carboxypeptidase X 2 (M14 family), metallocarboxypeptidase 2 (predicted)
Genes	CPXM2 (Hs), Cpxm2 (Mm), Cpxm2 (Rn)
Ensembl ID	ENSG00000121898 (Hs), ENSMUSG00000030862 (Mm), ENSRNOG00000015902 (Rn)

Carboxypeptidase Z Show »« Hide

Carnosine dipeptidase 1 (metallopeptidase M20 family) Show »« Hide

Nomenclature	Carnosine dipeptidase 1 (metallopeptidase M20 family)
Other names	Glutamate carboxypeptidase-like protein 2, MGC10825, CN1, CPGL2, HsT2308, carnosinase 1, MGC93742, CNDP dipeptidase 1, beta-Ala-His dipeptidase, similar to carnosinase 1
Genes	CNDP1 (Hs), Cndp1 (Mm), Cndp1 (Rn)
Ensembl ID	ENSG00000150656 (Hs), ENSMUSG00000056162 (Mm), ENSRNOG00000027739 (Rn)

Carnosine dipeptidase 2 Show »« Hide

Nomenclature	Carnosine dipeptidase 2
Other names	HsT2298, PEPA, FLJ10830, CN2, CPGL, peptidase A, cytosolic nonspecific dipeptidase (EC 3.4.13.18), Cndp2_predicted, LOC291394, CNDP dipeptidase 2 (metallopeptidase M20 family) (predicted), cytosolic non-specific dipeptidase, cytosolic nonspecific dipeptidase 2, Pep1, Pep-1, Dip-2
Genes	CNDP2 (Hs), Cndp2 (Mm), Cndp2 (Rn)
Ensembl ID	ENSG00000133313 (Hs), ENSMUSG00000024644 (Mm), ENSRNOG00000015591 (Rn)

Dipeptidyl-peptidase 7 Show »« Hide

Nomenclature	Dipeptidyl-peptidase 7
Other names	DPPII, dipeptidylpeptidase 7, Dpp2, DPP II, dipeptidyl aminopeptidase II, dipeptidyl peptidase 2, dipeptidyl peptidase 7, dipeptidyl peptidase II, dipeptidyl-peptidase 2, dipeptidyl-peptidase II, quiescent cell proline dipeptidase, QPP
Genes	DPP7 (Hs), Dpp7 (Mm), Dpp7 (Rn)
Ensembl ID	ENSG00000176978 (Hs), ENSMUSG00000026958 (Mm), ENSRNOG00000012640 (Rn)

Folate hydrolase (prostate-specific membrane antigen) 1 Show »« Hide

Nomenclature	Folate hydrolase (prostate-specific membrane antigen) 1
Other names	GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, FOLH, glutamate carboxylase II, glutamate carboxypeptidase II, Naalad, FGCP, N-acetylated alpha-linked acidic dipeptidase, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, folate hydrolase, folate hydrolase 1, folylpoly-gamma-glutamate carboxypeptidase, glutamate carboxypeptidase 2, mGCP, membrane glutamate carboxypeptidase, prostate-specific membrane antigen homolog, pteroylpoly-gamma-glutamate carboxypeptidase, prostate-specific membrane antigen, mopsm
Genes	FOLH1 (Hs), Folh1 (Mm), Folh1 (Rn)
Ensembl ID	ENSG00000086205 (Hs), ENSMUSG00000001773 (Mm), ENSRNOG00000013770 (Rn)

Folate hydrolase 1B Show »« Hide

Nomenclature	Folate hydrolase 1B
Other names	FOLH2, FOLHP, GCPIII, PSMAL, folate hydrolase 2, prostate specific membrane antigen like protein, Cell growth-inhibiting gene 26 protein, glutamate carboxypeptidase III
Genes	FOLH1B (Hs)
Ensembl ID	ENSG00000134612 (Hs)

N-Acetylated α-linked acidic dipeptidase-like 1 Show »« Hide

Nomenclature	N-Acetylated α-linked acidic dipeptidase-like 1
Other names	ileal peptidase I100, Naaladasel, 100 kDa ileum brush border membrane protein, I100, N-acetylated alpha-linked acidic dipeptidase-like (ileal peptidase I100), N-acetylated alpha-linked acidic dipeptidase-like 1, N-acetylated-alpha-linked acidic dipeptidase-like protein, NAALADase L, ileal dipeptidylpeptidase, LOC381204
Genes	NAALADL1 (Hs), Naaladl1 (Mm), Naaladl1 (Rn)
Ensembl ID	ENSG00000168060 (Hs), ENSMUSG00000054999 (Mm), ENSRNOG00000021000 (Rn)

N-Acetylated α-linked acidic dipeptidase 2 Show »« Hide

Nomenclature	N-Acetylated α-linked acidic dipeptidase 2
Other names	NAALADASE2, NAADALASE2, GPCIII, glutamate carboxypeptidase III, LOC300384, Naalad2_predicted, N-acetylated alpha-linked acidic dipeptidase 2, N-acetylated alpha-linked acidic dipeptidase 2 (predicted), N-acetylated-alpha-linked acidic dipeptidase 2, D9Ertd285e, GCPIII, Folh1b, GCP3
Genes	NAALAD2 (Hs), Naalad2 (Mm), Naalad2 (Rn)
Ensembl ID	ENSG00000077616 (Hs), ENSMUSG00000043943 (Mm), ENSRNOG00000005955 (Rn)

Plasma glutamate carboxypeptidase Show »« Hide

Nomenclature	Plasma glutamate carboxypeptidase
Other names	AC010859.1
Ensembl ID	ENSG00000104324 (Hs)

Endopeptidases

Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Neutral endopeptidase Show »« Hide

Nomenclature

Neutral endopeptidase

Other names

NEP, Enkephalinase, neprilysin, CALLA, CD10, neutral endopeptidase, MGC93576, SFE, Membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase), atriopeptidase, membrane metallo endopeptidase, neutral endopeptidase 24.11, skin fibroblast elastase

Genes

MME (Hs), Mme (Mm), Mme (Rn)

Ensembl ID

ENSG00000196549 (Hs), ENSMUSG00000027820 (Mm), ENSRNOG00000009514 (Rn)

EC number

3.4.24.11

Endogenous substrates

enkephalins

Selective inhibitors
(pIC₅₀)

thiorphan

Dipeptidyl peptidase IV Show »« Hide

Nomenclature

Dipeptidyl peptidase IV

Other names

CD26, adenosine deaminase complexing protein-2, ADCP2, DPPIV, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2), adenosine deaminase complexing protein 2, DPP IV, Dipeptidyl peptidase 4, GP110 glycoprotein, T-cell activation antigen CD26, bile canaliculus domain-specific membrane glycoprotein, dipeptidyl peptidase IV, THAM, Dpp-4

Genes

DPP4 (Hs), Dpp4 (Mm), Dpp4 (Rn)

Ensembl ID

ENSG00000197635 (Hs), ENSMUSG00000035000 (Mm), ENSRNOG00000030763 (Rn)

EC number

3.4.14.5

Endogenous substrates

glucagon-like peptide 1

Angiotensin-converting enzyme 1 Show »« Hide

Nomenclature

Angiotensin-converting enzyme 1

Common abbreviation

ACE1

Other names

ACE, Dipeptidyl carboxypeptidase I, Kininase II, CD143, DCP1, ACE1, StsRR92, Dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme), angiotensin 1 converting enzyme, angiotensin 1 converting enzyme 1, angiotensin I converting enzyme 1, angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1), angiotensin converting enzyme, angiotensin-converting enzyme

Genes

ACE (Hs), Ace (Mm), Ace (Rn)

Ensembl ID

ENSG00000159640 (Hs), ENSMUSG00000020681 (Mm), ENSRNOG00000007467 (Rn)

EC number

3.4.15.1

Endogenous substrates

angiotensin I > angiotensin II

Selective inhibitors
(pIC₅₀)

captopril

Comment

Hip-His Leu has been used experimentally as a probe for ACE1.

ACE1 appears to express a distinct GPI hydrolase activity [10].

Angiotensin-converting enzyme 2 Show »« Hide

Nomenclature

Angiotensin-converting enzyme 2

Common abbreviation

ACE2

Other names

ACE-related carboxypeptidase, angiotensin I converting enzyme 2, angiotensin-converting enzyme 2, anigotensin-converting enzyme-related carboxypeptidase, renal angiotensin-converting enzyme 2

Genes

ACE2 (Hs), Ace2 (Mm), Ace2 (Rn)

Ensembl ID

ENSG00000130234 (Hs), ENSMUSG00000015405 (Mm)

EC number

3.4.15.1

Endogenous substrates

angiotensin I > angiotensin-(1-9) [4]

Selective inhibitors
(pIC₅₀)

captopril

Comment

Abz-Ser-Pro-Tyr(NO₂)-OH has been used experimentally as a probe for ACE2

Endothelin-converting enzyme 1 Show »« Hide

Nomenclature

Endothelin-converting enzyme 1

Common abbreviation

ECE1

Other names

ECE, ECE-1, Endothelin-converting enzyme, endothelin converting enzyme 1, endothelin-converting enzyme 1

Genes

ECE1 (Hs), Ece1 (Mm), Ece1 (Rn)

Ensembl ID

ENSG00000117298 (Hs), ENSMUSG00000057530 (Mm), ENSRNOG00000014241 (Rn)

EC number

3.4.24.71

Endogenous substrates

ET-1, ET-2, ET-3

Selective inhibitors
(pIC₅₀)

SM19712 [18]

Endothelin-converting enzyme 2 Show »« Hide

Caspases

Overview Show »« Hide

Caspases, (E.C. 3.4.22.-) which derive their name from Cysteine ASPartate-specific proteASES, include at least two families; initiator caspases (caspases 2, 8, 9 and 10), which are able to hydrolyse and activate a second family of effector caspases (caspases 3, 6 and 7), which themselves are able to hydrolyse further cellular proteins to bring about programmed cell death. Caspases are heterotetrameric, being made up of two pairs of subunits, generated by a single gene product, which is proteolysed to form the mature protein. Members of the mammalian inhibitors of apoptosis proteins (IAP) are able to bind the procaspases, thereby preventing maturation to active proteinases.

Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Caspase 1 Show »« Hide

Nomenclature

Caspase 1

Other names

CASP1, interleukin-1β convertase, IL-1BC, interleukin-1 β-converting enzyme, IL-1 β-converting enzyme, ICE, p45, IL1BC, caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase), caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase), caspase-1, interleukin 1, beta, convertase, CASP-1, IL-1 beta-converting enzyme, IL-1BC, Interleukin 1beta converting enzyme, caspase 1, caspase 1 apoptosis-related cysteine protease (interleukin 1 beta convertase), interleukin 1 beta convertase, interleukin-1 beta convertase, interleukin-1 beta-converting enzyme, interleukin 1 beta-converting enzyme

Genes

CASP1 (Hs), Casp1 (Mm), Casp1 (Rn)

Ensembl ID

ENSG00000137752 (Hs), ENSMUSG00000025888 (Mm), ENSRNOG00000007372 (Rn)

EC number

3.4.22.36

Endogenous substrates

Rho GDP dissociation inhibitor beta

parkin

pro-caspase 4

pro-interleukin-1β

Selective inhibitors
(pIC₅₀)

Z-YVAD-FMK [1]

Comment

Consists of caspase-1 subunit p20 and caspase-1 subunit p10 (see Uniprot entry)

Caspase 2 Show »« Hide

Nomenclature

Caspase 2

Other names

CASP2, ICH-1 protease, neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, NEDD2, ICH1, PPP1R57, neural precursor cell expressed, developmentally down-regulated 2, protein phosphatase 1, regulatory subunit 57, CASP-2, caspase 2, caspase-2, protease ICH-1, Ich-1

Genes

CASP2 (Hs), Casp2 (Mm), Casp2 (Rn)

Ensembl ID

ENSG00000106144 (Hs), ENSMUSG00000029863 (Mm), ENSRNOG00000016707 (Rn)

EC number

3.4.22.55

Selective inhibitors
(pIC₅₀)

Z-VDVAD-FMK [5]

Comment

Consists of caspase-2 subunit p18, caspase-2 subunit p13, and caspase-2 subunit p12 (see Uniprot entry)

Caspase 3 Show »« Hide

Nomenclature

Caspase 3

Other names

CASP3, apopain, cysteine protease CPP32, Yama protein, SREBP cleavage activity 1, SCA-1, CPP32, CPP32B, Yama, caspase 3, apoptosis-related cysteine protease, CPP32beta, Lice, MGC93645, CASP-3, CPP-32, Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease), Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease), IRP, caspase 3, caspase 3, apoptosis related cysteine protease, caspase-3, protein Yama, CC3, mldy, AC-3

Genes

CASP3 (Hs), Casp3 (Mm), Casp3 (Rn)

Ensembl ID

ENSG00000164305 (Hs), ENSMUSG00000031628 (Mm), ENSRNOG00000010475 (Rn)

EC number

3.4.22.56

Endogenous activators

Caspase 8, caspase 9, caspase 10, GrB

Endogenous substrates

huntingtin

retinoblastoma-associated protein

caspase 3

ICAD

PARP

PKCδ

pro-caspase 7

Activators

PAC1 [14]

PETCM [9]

Selective inhibitors
(pIC₅₀)

AZ10417808 [16]

Z-DEVD-FMK [2]

Z-DQMD-FMK [8]

Comment

Consists of caspase-3 subunit p17 and caspase-3 subunit p12 (see Uniprot entry)

Caspase 4 Show »« Hide

Nomenclature

Caspase 4

Other names

CASP4, ICH-2 protease, TX protease, ICE(rel)-II, ICE(rel)II, ICH-2, TX, caspase 4, apoptosis-related cysteine protease, Casp11, MGC124949, caspase 11, caspase 4, ich-3, Caspase-11

Genes

CASP4 (Hs), Casp4 (Mm), Casp4 (Rn)

Ensembl ID

ENSG00000196954 (Hs), ENSMUSG00000033538 (Mm), ENSRNOG00000033697 (Rn)

EC number

3.4.22.57

Endogenous substrates

pro-caspase 1

Comment

Consists of caspase-4 subunit 1 and caspase-4 subunit 2 (see Uniprot entry)

Caspase 5 Show »« Hide

Nomenclature

Caspase 5

Other names

CASP5, ICH-3 protease, TY protease, ICE(rel)-III, ICE(rel)III, caspase 5, apoptosis-related cysteine protease

Genes

CASP5 (Hs)

Ensembl ID

ENSG00000137757 (Hs)

EC number

3.4.22.58

Selective inhibitors
(pIC₅₀)

Z-WEHD-FMK [13]

Comment

Consists of caspase-5 subunit p20 and caspase-5 subunit p10 (see Uniprot entry)

Caspase 6 Show »« Hide

Nomenclature

Caspase 6

Other names

CASP6, apoptotic protease Mch-2, MCH2, caspase 6, apoptosis-related cysteine protease, MGC93335, CASP-6, caspase 6, caspase-6, mCASP-6

Genes

CASP6 (Hs), Casp6 (Mm), Casp6 (Rn)

Ensembl ID

ENSG00000138794 (Hs), ENSMUSG00000027997 (Mm), ENSRNOG00000009508 (Rn)

EC number

3.4.22.59

Endogenous activators

Caspase 8, caspase 9, caspase 10, GrB

Selective inhibitors
(pIC₅₀)

Z-VEID-FMK [15]

Comment

Consists of caspase-6 subunit p18 and caspase-6 subunit p11 (see Uniprot entry)

Caspase 7 Show »« Hide

Nomenclature

Caspase 7

Other names

CASP7, ICE-like apoptotic protease 3, ICE-LAP3, apoptotic protease Mch-3, CMH-1, MCH3, caspase 7, apoptosis-related cysteine protease, caspase 7, caspase-7, ICE-IAP3

Genes

CASP7 (Hs), Casp7 (Mm), Casp7 (Rn)

Ensembl ID

ENSG00000165806 (Hs), ENSMUSG00000025076 (Mm), ENSRNOG00000016836 (Rn)

EC number

3.4.22.60

Endogenous activators

Caspase 8, caspase 9, caspase 10, GrB

Endogenous substrates

huntingtin

retinoblastoma-associated protein

caspase 3

ICAD

PARP

PKCδ

Pro-caspase 7

Comment

Consists of caspase-7 subunit p20 and caspase-7 subunit p11 (see Uniprot entry)

Caspase 8 Show »« Hide

Nomenclature

Caspase 8

Other names

CASP8, CE-like apoptotic protease 5, MORT1-associated CED-3 homolog, MACH, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, apoptotic cysteine protease, apoptotic protease Mch-5, CAP4, MCH5, Casp-8, caspase 8, apoptosis-related cysteine protease, caspase 8, caspase-8

Genes

CASP8 (Hs), Casp8 (Mm), Casp8 (Rn)

Ensembl ID

ENSG00000064012 (Hs), ENSMUSG00000026029 (Mm), ENSRNOG00000012331 (Rn)

EC number

3.4.22.61

Endogenous activators

DISC

Endogenous substrates

BH3 interacting-domain death agonist

FLICE-like inhibitory protein

caspase 8

pro-caspase 3

pro-caspase 6

pro-caspase 7

Selective inhibitors
(pIC₅₀)

Z-IETD-FMK [7]

Comment

Consists of caspase-8 subunit p18 and caspase-8 subunit p10 (see Uniprot entry)

Caspase 9 Show »« Hide

Nomenclature

Caspase 9

Other names

CASP9, ICE-like apoptotic protease 6, ICE-LAP6, apoptotic protease Mch-6, apoptotic protease-activating factor 3, APAF-3, MCH6, PPP1R56, caspase 9, apoptosis-related cysteine protease, protein phosphatase 1, regulatory subunit 56, Apaf3, Casp-9-CTD, Casp9_v1, 25 kDa caspase-9 dominant negative protein, apoptotic protease activating factor 3, caspase 9, apoptosis-related cysteine peptidase, caspase-9, caspase-9 dominant negative form, caspase-9-carboxyl-terminal divergent

Genes

CASP9 (Hs), Casp9 (Mm), Casp9 (Rn)

Ensembl ID

ENSG00000132906 (Hs), ENSMUSG00000028914 (Mm), ENSRNOG00000012944 (Rn)

EC number

3.4.22.62

Endogenous substrates

caspase 9

PARP

pro-caspase 3

pro-caspase 6

pro-caspase 7

Selective inhibitors
(pIC₅₀)

Z-LEHD-FMK [12]

Comment

Consists of caspase-9 subunit p35 and caspase-9 subunit p10 (see Uniprot entry)

Caspase 10 Show »« Hide

Nomenclature

Caspase 10

Other names

FLICE2, CASP10, ICE-like apoptotic protease 4, apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2, MCH4, caspase 10, apoptosis-related cysteine protease

Genes

CASP10 (Hs)

Ensembl ID

ENSG00000003400 (Hs)

EC number

3.4.22.63

Endogenous activators

DISC

Endogenous substrates

caspase 10

pro-caspase 3

pro-caspase 6

pro-caspase 7

Comment

Consists of caspase-10 subunit p23/17 and caspase-10 subunit p12 (see Uniprot entry)

Caspase 14 Show »« Hide

Nomenclature	Caspase 14
Other names	CASP14, MICE, MGC119078, MGC119079, caspase 14, apoptosis-related cysteine protease, apoptosis-related cysteine protease, Casp14_predicted, LOC299587, caspase 14, caspase 14 (predicted), caspase-14, mini-ICE
Genes	CASP14 (Hs), Casp14 (Mm), Casp14 (Rn)
Ensembl ID	ENSG00000105141 (Hs), ENSMUSG00000005355 (Mm), ENSRNOG00000007352 (Rn)
EC number	3.4.22.-
Comment	Consists of caspase-14 subunit p19 and caspase-14 subunit p10 (see Uniprot entry)

Comments Show »« Hide

Cell-surface protein and extracellular matrix metalloproteinases

Overview Show »« Hide

Matrix metalloproteinases (MMP) are calcium- and zinc-dependent proteinases regulating the extracellular matrix and are often divided (e.g. [19]) on functional and structural bases into gelatinases, collagenases, stromyelinases and matrilysins, as well as membrane type-MMP (MT-MMP).

A number of small molecule ‘broad spectrum’ inhibitors of MMP have been described, including marimastat and batimastat.

Tissue inhibitors of metalloproteinase (TIMP) proteins are endogenous inhibitors acting to chelate MMP proteins: TIMP1, TIMP2, TIMP3, TIMP4

Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

MMP1 Show »« Hide

Nomenclature	MMP1
Other names	Collagenase-1, interstitial collagenase, fibroblast collagenase, CLG, matrix metalloproteinase 1 (interstitial collagenase), LOC300339, Mmp1a_predicted, matrix metallopeptidase 1a, matrix metallopeptidase 1a (interstitial collagenase) (predicted), matrix metalloproteinase 1a (interstitial collagenase), matrix metalloproteinase 1a (interstitial collagenase) (predicted), Mcol-A
Genes	MMP1 (Hs), Mmp1a (Mm), Mmp1a (Rn)
Ensembl ID	ENSG00000196611 (Hs), ENSMUSG00000043089 (Mm), ENSRNOG00000032353 (Rn)

MMP2 Show »« Hide

Nomenclature

MMP2

Other names

Gelatinase-A, 72 kDa type IV collagenase precursor, TBE- 1, CLG4, CLG4A, TBE-1, matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase), matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), 72 KDa type IV collagenase, 72 kDa gelatinase, MMP-2, gelatinase A, matrix metalloproteinase 2, matrix metalloproteinase 2 (72 KDa type IV collagenase), matrix metalloproteinase-2, 72kDa gelatinase, 72kDa type IV collagenase, GelA

Genes

MMP2 (Hs), Mmp2 (Mm), Mmp2 (Rn)

Ensembl ID

ENSG00000087245 (Hs), ENSMUSG00000031740 (Mm)

Selective inhibitors
(pIC₅₀)

ARP100 [17]

MMP3 Show »« Hide

Nomenclature	MMP3
Other names	Stromelysin-1, transin-1, STMY1, STMY, matrix metalloproteinase 3 (stromelysin 1, progelatinase), MMP-3, PTR1 protein, SL-1, matrix metalloproteinase 3, matrix metalloproteinase-3, stromelysin 1, progelatinase, Str1, SLN-1, SLN1, STR-1
Genes	MMP3 (Hs), Mmp3 (Mm), Mmp3 (Rn)
Ensembl ID	ENSG00000149968 (Hs), ENSMUSG00000043613 (Mm), ENSRNOG00000032626 (Rn)

MMP7 Show »« Hide

Nomenclature	MMP7
Other names	Matrilysin, PUMP-1 protease, uterine metalloproteinase, matrin, MPSL1, PUMP-1, matrix metalloproteinase 7 (matrilysin, uterine), MPMM, MMP-7, Matrix metalloproteinase 7 (matrilysin), matrix metallopeptidase 7, matrix metalloproteinase 7, matrix metalloproteinase-7, MAT
Genes	MMP7 (Hs), Mmp7 (Mm), Mmp7 (Rn)
Ensembl ID	ENSG00000137673 (Hs), ENSMUSG00000018623 (Mm), ENSRNOG00000010507 (Rn)

MMP8 Show »« Hide

Nomenclature	MMP8
Other names	Neutrophil collagenase, PMNL collagenase, CLG1, matrix metalloproteinase 8 (neutrophil collagenase), MMP-8, matrix metallopeptidase 8, matrix metalloproteinase-8, neutrophil collagenease, Collagenase-2
Genes	MMP8 (Hs), Mmp8 (Mm), Mmp8 (Rn)
Ensembl ID	ENSG00000118113 (Hs), ENSMUSG00000005800 (Mm), ENSRNOG00000009907 (Rn)

MMP9 Show »« Hide

Nomenclature	MMP9
Other names	Gelatinases-B, 92 kDa type IV collagenase, GELB, CLG4B, matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IV collagenase), matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), 92 kDa gelatinase, 92-kDa type IV collagenase, MMP-9, gelatinase B, matrix metallopeptidase 9, matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase), matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase), matrix metalloproteinase-9, Gel B, B/MMP9
Genes	MMP9 (Hs), Mmp9 (Mm), Mmp9 (Rn)
Ensembl ID	ENSG00000100985 (Hs), ENSMUSG00000017737 (Mm), ENSRNOG00000017539 (Rn)

MMP10 Show »« Hide

Nomenclature	MMP10
Other names	Stromelysin-2, transin-2, STMY2, matrix metalloproteinase 10 (stromelysin 2), MMP-10, SL-2, matrix metallopeptidase 10, matrix metalloproteinase 10, matrix metalloproteinase-10, stromelysin 2, transformation-associated protein 34A
Genes	MMP10 (Hs), Mmp10 (Mm), Mmp10 (Rn)
Ensembl ID	ENSG00000166670 (Hs), ENSMUSG00000047562 (Mm), ENSRNOG00000032832 (Rn)

MMP11 Show »« Hide

Nomenclature	MMP11
Other names	Stromelysin-3, STMY3, matrix metalloproteinase 11 (stromelysin 3), ST3, MMP-11, SL-3, matrix metallopeptidase 11, matrix metalloproteinase 11, matrix metalloproteinase-11, stromelysin 3
Genes	MMP11 (Hs), Mmp11 (Mm), Mmp11 (Rn)
Ensembl ID	ENSG00000099953 (Hs), ENSMUSG00000000901 (Mm), ENSRNOG00000028344 (Rn)

MMP12 Show »« Hide

Nomenclature	MMP12
Other names	Macrophage metalloelastase, macrophage elastase, HME, matrix metalloproteinase 12 (macrophage elastase), Mme, MMP-12, matrix metallopeptidase 12, matrix metalloproteinase 12, matrix metalloproteinase-12, Mmel
Genes	MMP12 (Hs), Mmp12 (Mm), Mmp12 (Rn)
Ensembl ID	ENSG00000110347 (Hs), ENSMUSG00000049723 (Mm), ENSRNOG00000030187 (Rn)

MMP13 Show »« Hide

Nomenclature

MMP13

Other names

Collagenase-3, CLG3, matrix metalloproteinase 13 (collagenase 3), collagenase 3, MMP-13, UMRCASE, matrix metalloproteinase 13, matrix metalloproteinase-13, interstitial collagenase, collagenase-1, Clg, Mmp1

Genes

MMP13 (Hs), Mmp13 (Mm), Mmp13 (Rn)

Ensembl ID

ENSG00000137745 (Hs), ENSMUSG00000050578 (Mm), ENSRNOG00000008478 (Rn)

Selective inhibitors
(pIC₅₀)

CL82198 [3]

WAY170523 [3]

MMP14 Show »« Hide

Nomenclature	MMP14
Other names	MT1-MMP, MMP- X1, matrix metalloproteinase 14 (membrane-inserted), membrane type 1 metalloprotease, MMP-14, MT-MMP 1, MT1MMP, MTMMP1, matrix metalloproteinase 14 membrane-inserted, matrix metalloproteinase 14, membrane-inserted, matrix metalloproteinase-14, membrane type 1-matrix metalloproteinase, membrane-type matrix metalloproteinase 1, membrane-type-1 matrix metalloproteinase, Membrane type 1-MMP
Genes	MMP14 (Hs), Mmp14 (Mm), Mmp14 (Rn)
Ensembl ID	ENSG00000157227 (Hs), ENSMUSG00000000957 (Mm), ENSRNOG00000010947 (Rn)

MMP15 Show »« Hide

Nomenclature	MMP15
Other names	MT2-MMP, SMCP- 2, MT2-MMP, MTMMP2, SMCP-2, matrix metalloproteinase 15 (membrane-inserted), LOC291848, Mmp15_predicted, matrix metallopeptidase 15, matrix metallopeptidase 15 (predicted), matrix metalloproteinase 15, matrix metalloproteinase 15 (predicted), Membrane type 2-MMP
Genes	MMP15 (Hs), Mmp15 (Mm), Mmp15 (Rn)
Ensembl ID	ENSG00000102996 (Hs), ENSMUSG00000031790 (Mm), ENSRNOG00000012622 (Rn)

MMP16 Show »« Hide

Nomenclature	MMP16
Other names	MT3-MMP, MMP- X2, C8orf57, DKFZp761D112, matrix metalloproteinase 16 (membrane-inserted), chromosome 8 open reading frame 57, MMP-16, MT-MMP 3, MT3MMP, MTMMP3, matrix metallopeptidase 16, matrix metalloproteinase 16, matrix metalloproteinase-16, membrane-type matrix metalloproteinase 3, membrane-type-3 matrix metalloproteinase, Membrane type 3-MMP
Genes	MMP16 (Hs), Mmp16 (Mm), Mmp16 (Rn)
Ensembl ID	ENSG00000156103 (Hs), ENSMUSG00000028226 (Mm), ENSRNOG00000005708 (Rn)

MMP17 Show »« Hide

Nomenclature	MMP17
Other names	MT4-MMP, matrix metalloproteinase 17 (membrane-inserted), LOC288626, Mmp17_predicted, matrix metallopeptidase 17, matrix metallopeptidase 17 (predicted), matrix metalloproteinase 17, matrix metalloproteinase 17 (predicted), matrix metalloproteinase-17, membrane type-4 matrix metalloproteinase
Genes	MMP17 (Hs), Mmp17 (Mm), Mmp17 (Rn)
Ensembl ID	ENSG00000198598 (Hs), ENSMUSG00000029436 (Mm), ENSRNOG00000023643 (Rn)

MMP19 Show »« Hide

Nomenclature	MMP19
Other names	Matrix metalloproteinase RASI, MMP18, RASI-1, matrix metalloproteinase 19, LOC304608, Mmp19_predicted, MMP-19, matrix metallopeptidase 19, matrix metalloproteinase 19 (predicted), matrix metalloproteinase-19
Genes	MMP19 (Hs), Mmp19 (Mm), Mmp19 (Rn)
Ensembl ID	ENSG00000123342 (Hs), ENSMUSG00000025355 (Mm), ENSRNOG00000006778 (Rn)

MMP20 Show »« Hide

Nomenclature	MMP20
Other names	Enamelysin, enamel metalloproteinase, matrix metalloproteinase 20 (enamelysin), LOC300341, Mmp20_predicted, matrix metallopeptidase 20, matrix metallopeptidase 20 (enamelysin), matrix metallopeptidase 20 (enamelysin) (predicted), matrix metalloproteinase-20
Genes	MMP20 (Hs), Mmp20 (Mm), Mmp20 (Rn)
Ensembl ID	ENSG00000137674 (Hs), ENSMUSG00000018620 (Mm), ENSRNOG00000021896 (Rn)

MMP21 Show »« Hide

Nomenclature	MMP21
Other names	matrix metalloproteinase 21, LOC293573, Mmp21_predicted, matrix metallopeptidase 21, matrix metalloproteinase 21 (predicted), matrix metalloproteinase-21
Genes	MMP21 (Hs), Mmp21 (Mm), Mmp21 (Rn)
Ensembl ID	ENSG00000154485 (Hs), ENSMUSG00000030981 (Mm), ENSRNOG00000017756 (Rn)

MMP23 Show »« Hide

Nomenclature	MMP23
Other names	MMP23B, Matrix metallopeptidase 21, MMP-21, matrix metalloprotease 22, MMP-22, Femalysin, MIFR-1, MMP22, MIFR, matrix metalloproteinase 23B, matrix metalloproteinase 22, matrix metalloproteinase in the female reproductive tract, MMP-23, Matrix metalloproteinase 23, matrix metallopeptidase 23, matrix metalloproteinase-23, metaloprotease in the female reproductive tract, CA-MMP, cysteine array matrix metalloproteinase
Genes	MMP23B (Hs), Mmp23 (Mm), Mmp23 (Rn)
Ensembl ID	ENSG00000189409 (Hs), ENSMUSG00000029061 (Mm), ENSRNOG00000017477 (Rn)

MMP24 Show »« Hide

Nomenclature	MMP24
Other names	MT5-MMP, matrix metalloproteinase 24 (membrane-inserted), membrane-type 5 matrix metalloproteinase, MT5MMP, MTMMP5, MMP-24, MT-MMP 5, matrix metallopeptidase 24, matrix metalloproteinase-24, membrane-type matrix metalloproteinase 5, membrane-type-5 matrix metalloproteinase, Membrane type 5-MMP
Genes	MMP24 (Hs), Mmp24 (Mm), Mmp24 (Rn)
Ensembl ID	ENSG00000125966 (Hs), ENSMUSG00000027612 (Mm)

MMP25 Show »« Hide

Nomenclature	MMP25
Other names	MT6-MMP, leukolysin, MMPL1, MMP20, matrix metalloproteinase 25, matrix metallopeptidase-like 1, LOC302963, Mmp25_predicted, matrix metalloproteinase 25 (predicted), matrix metalloproteinase-25
Genes	MMP25 (Hs), Mmp25 (Mm), Mmp25 (Rn)
Ensembl ID	ENSG00000008516 (Hs), ENSMUSG00000023903 (Mm)

MMP26 Show »« Hide

Nomenclature	MMP26
Other names	Matrilysin-2, endometase, MGC126590, MGC126592, matrix metalloproteinase 26, matrilysin 2
Genes	MMP26 (Hs)
Ensembl ID	ENSG00000167346 (Hs)

MMP27 Show »« Hide

Nomenclature	MMP27
Other names	matrix metalloproteinase 27, matrix metalloprotease 27, LOC300340, Mmp27_predicted, matrix metallopeptidase 27, matrix metalloproteinase 27 (predicted), matrix metalloproteinase-27, LOC234911
Genes	MMP27 (Hs), Mmp27 (Mm), Mmp27 (Rn)
Ensembl ID	ENSG00000137675 (Hs), ENSMUSG00000070323 (Mm), ENSRNOG00000040208 (Rn)

MMP28 Show »« Hide

Nomenclature	MMP28
Other names	Epilysin, MMP-25, MM28, MMP-28, matrix metalloproteinase 28, LOC303384, Mmp28_predicted, matrix metallopeptidase 28, matrix metallopeptidase 28 (epilysin), matrix metallopeptidase 28 (epilysin) (predicted), matrix metalloproteinase 28 (epilysin), matrix metalloproteinase 28 (epilysin) (predicted), matrix metalloproteinase-28
Genes	MMP28 (Hs), Mmp28 (Mm), Mmp28 (Rn)
Ensembl ID	ENSG00000129270 (Hs), ENSMUSG00000020682 (Mm), ENSRNOG00000010335 (Rn)

ADAM

Overview Show »« Hide

ADAM (A Disintegrin And Metalloproteinase domain containing proteins) metalloproteinases cleave cell-surface or transmembrane proteins to generate soluble and membrane-limited products.

Additional family members include AC123767.2 (cDNA FLJ58962, moderately similar to mouse ADAM3, ENSG00000231168), AL160191.3 (ADAM21-like protein, ENSG00000235812), AC136428.3-2 (ENSG00000185520) and ADAMDEC1 (decysin 1, ENSG00000134028).

Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

ADAM2 Show »« Hide

Nomenclature	ADAM2
Other names	Fertilin subunit β, PH30β, cancer/testis antigen 15, CT15, FTNB, PH-30b, PH30, fertilin beta, PH-30, beta, A disintegrin and metalloprotease domain 2 (Fertilin beta), ADAM 2, ADAM metallopeptidase domain 2, PH30-beta, a disintegrin and metallopeptidase domain 2, a disintegrin and metalloprotease domain (ADAM) 2, a disintegrin and metalloprotease domain 2, disintegrin and metalloproteinase domain-containing protein 2, fertilin subunit beta
Genes	ADAM2 (Hs), Adam2 (Mm), Adam2 (Rn)
Ensembl ID	ENSG00000104755 (Hs), ENSMUSG00000022039 (Mm), ENSRNOG00000017027 (Rn)

ADAM3 Show »« Hide

Nomenclature	ADAM3
Other names	ADAM3A, cyritestin 1, CYRN1, tMDCI, a disintegrin and metalloproteinase domain 3a (cyritestin 1), ADAM metallopeptidase domain 3A, pseudogene, ADAM metallopeptidase domain 3A, tMDC I, ADAM metallopeptidase domain 3, ADAM metallopeptidase domain 3A (cyritestin 1), ADAM metallopeptidase domain 3A (pseudogene), a disintegrin and metallopeptidase domain 3 (cyritestin), a disintegrin and metalloprotease domain 3, a disintegrin and metalloprotease domain 3 (cyritestin), cyritestin, Taz83, tMDC
Genes	ADAM3A (Hs), Adam3 (Mm), Adam3a (Rn)
Ensembl ID	ENSG00000197475 (Hs), ENSMUSG00000031553 (Mm), ENSRNOG00000017554 (Rn)

ADAM5 Show »« Hide

Nomenclature	ADAM5
Other names	ADAM5P, Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II, tMDC II, tMDCII, a disintegrin and metalloproteinase domain 5, MGC108772, ADAM metallopeptidase domain 5, a disintegrin and metalloprotease domain (ADAM) 5, a disintegrin and metalloprotease domain 5, disintegrin and metalloproteinase domain-containing protein 5
Genes	ADAM5 (Hs), Adam5 (Mm), Adam5 (Rn)
Ensembl ID	ENSG00000196115 (Hs), ENSMUSG00000031554 (Mm), ENSRNOG00000017518 (Rn)

ADAM6 Show »« Hide

ADAM7 Show »« Hide

Nomenclature	ADAM7
Other names	Sperm maturation-related glycoprotein GP-83, GP-83, EAPI, a disintegrin and metalloproteinase domain 7, 7, ADAM, ADAM 7, EAP, EAP I, I, ADAM metallopeptidase domain 7, a disintegrin and metallopeptidase domain 7, a disintegrin and metalloprotease domain (ADAM) 7, a disintegrin and metalloprotease domain 7, disintegrin and metalloproteinase domain-containing protein 7, epididymal apical protein I, EAP1
Genes	ADAM7 (Hs), Adam7 (Mm), Adam7 (Rn)
Ensembl ID	ENSG00000069206 (Hs), ENSMUSG00000022056 (Mm), ENSRNOG00000014054 (Rn)

ADAM8 Show »« Hide

Nomenclature	ADAM8
Other names	Cell surface antigen MS2, CD156a antigen, CD156, MS2, a disintegrin and metalloproteinase domain 8, LOC499285, RGD1566394, RGD1566394_predicted, ADAM metallopeptidase domain 8, a disintegrin and metallopeptidase domain 8, similar to cysteine-rich glycoprotein, similar to cysteine-rich glycoprotein (predicted), CD156a
Genes	ADAM8 (Hs), Adam8 (Mm), Adam8 (Rn)
Ensembl ID	ENSG00000151651 (Hs), ENSMUSG00000025473 (Mm), ENSRNOG00000017897 (Rn)

ADAM9 Show »« Hide

Nomenclature	ADAM9
Other names	Metalloprotease/disintegrin/cysteine-rich protein 9, myeloma cell metalloproteinase, meltrin γ, cellular disintegrin-related protein, CORD9, MDC9, KIAA0021, MCMP, Mltng, a disintegrin and metalloproteinase domain 9 (meltrin gamma), cone rod dystrophy 9, meltrin gamma, Adam9_predicted, LOC290834, ADAM metallopeptidase domain 9 (meltrin gamma), a disintegrin and metallopeptidase domain 9 (meltrin gamma), a disintegrin and metalloproteinase domain 9 (meltrin gamma) (predicted), disintegrin and metalloproteinase domain-containing protein 9
Genes	ADAM9 (Hs), Adam9 (Mm), Adam9 (Rn)
Ensembl ID	ENSG00000168615 (Hs), ENSMUSG00000031555 (Mm), ENSRNOG00000017231 (Rn)

ADAM10 Show »« Hide

Nomenclature	ADAM10
Other names	Mammalian disintegrin-metalloprotease, Kuzbanian protein homolog, CDw156, CD156c antigen, kuz, MADM, HsT18717, CD156c, a disintegrin and metalloproteinase domain 10, A disintegrin and metalloprotease domain (ADAM) 10, ADAM 10, ADAM metallopeptidase domain 10, a disintegrin and metallopeptidase domain 10, a disintegrin and metalloprotease domain 10, disintegrin and metalloproteinase domain-containing protein 10, kuzbanian
Genes	ADAM10 (Hs), Adam10 (Mm), Adam10 (Rn)
Ensembl ID	ENSG00000137845 (Hs), ENSMUSG00000054693 (Mm), ENSRNOG00000015038 (Rn)

ADAM11 Show »« Hide

Nomenclature	ADAM11
Other names	Metalloproteinase-like, disintegrin-like, and cysteine-rich protein, MDC, a disintegrin and metalloproteinase domain 11, metalloproteinase-like, disintegrin-like, cysteine-rich protein, Adam11_predicted, LOC360638, ADAM metallopeptidase domain 11, a disintegrin and metallopeptidase domain 11, a disintegrin and metallopeptidase domain 11 (predicted), a disintegrin and metalloprotease domain 11, a disintegrin and metalloprotease domain 11 (predicted), disintegrin and metalloproteinase domain-containing protein 11
Genes	ADAM11 (Hs), Adam11 (Mm), Adam11 (Rn)
Ensembl ID	ENSG00000073670 (Hs), ENSMUSG00000020926 (Mm), ENSRNOG00000002753 (Rn)

ADAM12 Show »« Hide

Nomenclature	ADAM12
Other names	Meltrin α, MCMPMltna, MLTN, a disintegrin and metalloproteinase domain 12 (meltrin alpha), meltrin alpha, Adam12_predicted, LOC309072, LOC679837, ADAM metallopeptidase domain 12, a disintegrin and metallopeptidase domain 12, a disintegrin and metallopeptidase domain 12 (meltrin alpha), a disintegrin and metallopeptidase domain 12 (meltrin alpha) (predicted), disintegrin and metalloproteinase domain-containing protein 12, similar to ADAM 12 precursor (A disintegrin and metalloproteinase domain 12) (Meltrin alpha), Mltna
Genes	ADAM12 (Hs), Adam12 (Mm), Adam12 (Rn)
Ensembl ID	ENSG00000148848 (Hs), ENSMUSG00000054555 (Mm), ENSRNOG00000018384 (Rn)

ADAM15 Show »« Hide

Nomenclature	ADAM15
Other names	Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15, MDC-15, Metalloprotease RGD disintegrin protein, metargidin, MDC15, a disintegrin and metalloproteinase domain 15 (metargidin), tMDC VI, tMDCVI, ADAM 15, CRII-7, a disintegrin and metalloproteinase domain (ADAM) 15 (metargidin), a disintegrin and metalloproteinase domain 15, disintegrin and metalloproteinase domain-containing protein 15
Genes	ADAM15 (Hs), Adam15 (Mm), Adam15 (Rn)
Ensembl ID	ENSG00000143537 (Hs), ENSMUSG00000028041 (Mm), ENSRNOG00000020590 (Rn)

ADAM17 Show »« Hide

Nomenclature	ADAM17
Other names	TNF α-converting enzyme, TNF α convertase, snake venom-like protease, CD156b antigen, TACE, cSVP, CD156B, tumor necrosis factor, alpha, converting enzyme, ADAM 17, ADAM metallopeptidase domain 17, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha-converting enzyme, a disintegrin and metallopeptidase domain 17, a disintegrin and metalloprotease domain 17, a disintegrin and metalloproteinase domain 17, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme), disintegrin and metalloproteinase domain-containing protein 17
Genes	ADAM17 (Hs), Adam17 (Mm), Adam17 (Rn)
Ensembl ID	ENSG00000151694 (Hs), ENSMUSG00000052593 (Mm), ENSRNOG00000007503 (Rn)

ADAM18 Show »« Hide

Nomenclature	ADAM18
Other names	Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III, tMDC III, ADAM27, tMDCIII, ADAM27, a disintegrin and metalloproteinase domain 18, tMDC III, ADAM 18, a disintegrin and metallopeptidase domain 18, disintegrin and metalloproteinase domain-containing protein 18, transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III, Dtgn3
Genes	ADAM18 (Hs), Adam18 (Mm), Adam18 (Rn)
Ensembl ID	ENSG00000168619 (Hs), ENSMUSG00000031552 (Mm), ENSRNOG00000017683 (Rn)

ADAM19 Show »« Hide

Nomenclature	ADAM19
Other names	Meltrin β, metalloprotease and disintegrin dendritic antigen marker, MADDAM, MLTNB, a disintegrin and metalloproteinase domain 19 (meltrin beta), meltrin beta, Adam19_mapped, LOC303068, Sox30, Sox30_predicted, ADAM metallopeptidase domain 19, SRY-box containing gene 30, SRY-box containing gene 30 (predicted), a disintegrin and metallopeptidase domain 19 (meltrin beta), a disintegrin and metalloproteinase domain 19 (meltrin beta) (mapped)
Genes	ADAM19 (Hs), Adam19 (Mm), Adam19 (Rn)
Ensembl ID	ENSG00000135074 (Hs), ENSMUSG00000011256 (Mm), ENSRNOG00000042980 (Rn)

ADAM20 Show »« Hide

Nomenclature	ADAM20
Other names	a disintegrin and metalloproteinase domain 20
Genes	ADAM20 (Hs)
Ensembl ID	ENSG00000134007 (Hs)

ADAM21 Show »« Hide

Nomenclature	ADAM21
Other names	ADAM21P, ADAM31, a disintegrin and metalloproteinase domain 21, Adam21_predicted, LOC314283, a disintegrin and metalloprotease domain 21 (predicted)
Genes	ADAM21 (Hs), Adam21 (Mm), Adam21 (Rn)
Ensembl ID	ENSG00000139985 (Hs), ENSMUSG00000008438 (Mm)

ADAM22 Show »« Hide

Nomenclature	ADAM22
Other names	Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2, metalloproteinase-disintegrin ADAM22-3, MDC2, a disintegrin and metalloproteinase domain 22, Adam22_mapped, ADAM metallopeptidase domain 22, a disintegrin and metalloprotease domain (ADAM) 22, a disintegrin and metalloprotease domain (ADAM) 22 (mapped), a disintegrin and metalloprotease domain 22, disintegrin and metalloproteinase domain-containing protein 22
Genes	ADAM22 (Hs), Adam22 (Mm), Adam22 (Rn)
Ensembl ID	ENSG00000008277 (Hs), ENSMUSG00000040537 (Mm), ENSRNOG00000042478 (Rn)

ADAM23 Show »« Hide

Nomenclature	ADAM23
Other names	Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3, MDC-3, MDC3, a disintegrin and metalloproteinase domain 23, Adam23_predicted, LOC301460, ADAM metallopeptidase domain 23, a disintegrin and metallopeptidase domain 23, a disintegrin and metallopeptidase domain 23 , a disintegrin and metallopeptidase domain 23 (predicted), a disintegrin and metalloprotease domain 23, a disintegrin and metalloprotease domain 23 (predicted), disintegrin and metalloproteinase domain-containing protein 23
Genes	ADAM23 (Hs), Adam23 (Mm), Adam23 (Rn)
Ensembl ID	ENSG00000114948 (Hs), ENSMUSG00000025964 (Mm), ENSRNOG00000012424 (Rn)

ADAM28 Show »« Hide

Nomenclature	ADAM28
Other names	Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L, MDC-L, epididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein II, eMDC II, eMDCII, MDC-Lm, MDC-Ls, ADAM23, a disintegrin and metalloproteinase domain 28, ADAM metallopeptidase domain 28, a disintegrin and metallopeptidase domain 28, a disintegrin and metalloprotease domain 28, disintegrin and metalloproteinase domain-containing protein 28, Dtgn1
Genes	ADAM28 (Hs), Adam28 (Mm), Adam28 (Rn)
Ensembl ID	ENSG00000042980 (Hs), ENSMUSG00000014725 (Mm), ENSRNOG00000014518 (Rn)

ADAM29 Show »« Hide

Nomenclature	ADAM29
Other names	Cancer/testis antigen 73, CT73, svph1, a disintegrin and metalloproteinase domain 29
Genes	ADAM29 (Hs), Adam29 (Mm)
Ensembl ID	ENSG00000168594 (Hs), ENSMUSG00000046258 (Mm)

ADAM30 Show »« Hide

Nomenclature	ADAM30
Other names	svph4, a disintegrin and metalloproteinase domain 30, LOC690547, ADAM metallopeptidase domain 30, a disintegrin and metallopeptidase domain 30, disintegrin and metalloproteinase domain-containing protein 30, similar to a disintegrin and metalloproteinase domain 30
Genes	ADAM30 (Hs), Adam30 (Mm), Adam30 (Rn)
Ensembl ID	ENSG00000134249 (Hs), ENSMUSG00000043468 (Mm), ENSRNOG00000019044 (Rn)

ADAM32 Show »« Hide

Nomenclature	ADAM32
Other names	a disintegrin and metalloproteinase domain 32, LOC361170, ADAM metallopeptidase domain 32, a disintegrin and metallopeptidase domain 32, a disintegrin and metalloprotease domain 32, metalloprotease/disintegrin
Genes	ADAM32 (Hs), Adam32 (Mm), Adam32 (Rn)
Ensembl ID	ENSG00000197140 (Hs), ENSMUSG00000037437 (Mm)

ADAM33 Show »« Hide

Nomenclature	ADAM33
Other names	C20orf153, DKFZp434K0521, dJ964F7.1, a disintegrin and metalloproteinase domain 33, chromosome 20 open reading frame 153, Adam33_predicted, LOC311425, ADAM metallopeptidase domain 33, a disintegrin and metallopeptidase domain 33, a disintegrin and metallopeptidase domain 33 (predicted), a disintegrin and metallopeptidase domain 33 (predicted)-like, a disintegrin and metalloprotease domain 33, a disintegrin and metalloprotease domain 33 (predicted), disintegrin and metalloproteinase domain-containing protein 33
Genes	ADAM33 (Hs), Adam33 (Mm), Adam33 (Rn)
Ensembl ID	ENSG00000149451 (Hs), ENSMUSG00000027318 (Mm), ENSRNOG00000021242 (Rn)

ADAMTS family

Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

ADAMTS1 Show »« Hide

Nomenclature	ADAMTS1
Other names	METH-1, C3-C5, METH1, KIAA1346, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1, A disintegrin and metalloproteinase with thrombospondin motifs 1, ADAM-TS 1, ADAM-TS1, ADAMTS-1, a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1), a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
Genes	ADAMTS1 (Hs), Adamts1 (Mm), Adamts1 (Rn)
Ensembl ID	ENSG00000154734 (Hs), ENSMUSG00000022893 (Mm), ENSRNOG00000001607 (Rn)

ADAMTS2 Show »« Hide

Nomenclature	ADAMTS2
Other names	Procollagen I/II amino propeptide-processing enzyme, procollagen I N-proteinase, PC I-NP, procollagen N-endopeptidase, pNPI, ADAMTS-3, hPCPNI, PCINP, ADAM-TS2, NPI, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2, LOC287899, RGD1565950, RGD1565950_predicted, A disintegrin and metalloproteinase with thrombospondin motifs 2, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2, similar to A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2, similar to A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2 (predicted), procollagen N-proteinase, a disintegrin and metalloproteinase with thrombospondin repeats
Genes	ADAMTS2 (Hs), Adamts2 (Mm), Adamts2 (Rn)
Ensembl ID	ENSG00000087116 (Hs), ENSMUSG00000036545 (Mm), ENSRNOG00000003572 (Rn)
EC number	3.4.24.14

ADAMTS3 Show »« Hide

Nomenclature	ADAMTS3
Other names	Procollagen II amino propeptide-processing enzyme, procollagen II N-proteinase, PC II-NP, KIAA0366, ADAMTS-4, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3, Adamts3_predicted, LOC305253, A disintegrin and metalloproteinase with thrombospondin motifs 3, ADAM metallopeptidase with thrombospondin type 1, motif 3, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3 (predicted)
Genes	ADAMTS3 (Hs), Adamts3 (Mm), Adamts3 (Rn)
Ensembl ID	ENSG00000156140 (Hs), ENSMUSG00000043635 (Mm), ENSRNOG00000027463 (Rn)

ADAMTS4 Show »« Hide

Nomenclature	ADAMTS4
Other names	Aggrecanase-1, ADMP-1, KIAA0688, ADAMTS-2, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4, A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, Aggrecanase, a disintegrin and metallopeptidase with thrombospondin motifs 4, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
Genes	ADAMTS4 (Hs), Adamts4 (Mm), Adamts4 (Rn)
Ensembl ID	ENSG00000158859 (Hs), ENSMUSG00000006403 (Mm)
EC number	3.4.24.82

ADAMTS5 Show »« Hide

Nomenclature	ADAMTS5
Other names	Aggrecanase-2, ADMP-2, ADAMTS11, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2), A disintegrin and metalloproteinase with thrombospondin motifs 5, ADAM metallopeptidase with thrombospondin type 1 motif, 5, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2), ADAM-TS5
Genes	ADAMTS5 (Hs), Adamts5 (Mm), Adamts5 (Rn)
Ensembl ID	ENSG00000154736 (Hs), ENSMUSG00000022894 (Mm), ENSRNOG00000001606 (Rn)

ADAMTS6 Show »« Hide

Nomenclature	ADAMTS6
Other names	ADAM-TS6, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6, a disintegrin and metalloproteinase with thrombospondin motifs 6, Adamts6_predicted, LOC361886, ADAM metallopeptidase with thrombospondin type 1 motif, 6, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6 (predicted)
Genes	ADAMTS6 (Hs), Adamts6 (Mm), Adamts6 (Rn)
Ensembl ID	ENSG00000049192 (Hs), ENSMUSG00000046169 (Mm), ENSRNOG00000012655 (Rn)

ADAMTS7 Show »« Hide

Nomenclature	ADAMTS7
Other names	COMPase, ADAM-TS7, DKFZp434H204, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7, a disintegrin and metalloprotease with thrombospondin motifs-7 preproprotein, ADAMTS7B, Adamts7_predicted, LOC315879, A disintegrin and metalloproteinase with thrombospondin motifs 7, ADAM metallopeptidase with thrombospondin type 1 motif, 7, ADAM-TS 7, ADAMTS-7, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7 (predicted), a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7 (predicted)
Genes	ADAMTS7 (Hs), Adamts7 (Mm), Adamts7 (Rn)
Ensembl ID	ENSG00000136378 (Hs), ENSMUSG00000032363 (Mm), ENSRNOG00000028036 (Rn)

ADAMTS8 Show »« Hide

Nomenclature	ADAMTS8
Other names	METH-2, METH-8, METH2, FLJ41712, ADAM-TS8, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8, Adamts8_predicted, LOC300475, A disintegrin and metalloproteinase with thrombospondin motifs 8, ADAM metallopeptidase with thrombospondin type 1 motif, 8, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 (predicted), a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 (predicted)
Genes	ADAMTS8 (Hs), Adamts8 (Mm), Adamts8 (Rn)
Ensembl ID	ENSG00000134917 (Hs), ENSMUSG00000031994 (Mm), ENSRNOG00000005574 (Rn)

ADAMTS9 Show »« Hide

Nomenclature	ADAMTS9
Other names	KIAA1312, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9, Adamts9_predicted, LOC312566, A disintegrin and metalloproteinase with thrombospondin motifs 9, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9 (predicted)
Genes	ADAMTS9 (Hs), Adamts9 (Mm), Adamts9 (Rn)
Ensembl ID	ENSG00000163638 (Hs), ENSMUSG00000030022 (Mm), ENSRNOG00000023257 (Rn)

ADAMTS10 Show »« Hide

Nomenclature	ADAMTS10
Other names	ADAM-TS10, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10, Adamts10_predicted, LOC362847, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10 (predicted), ZnMP
Genes	ADAMTS10 (Hs), Adamts10 (Mm), Adamts10 (Rn)
Ensembl ID	ENSG00000142303 (Hs), ENSMUSG00000024299 (Mm)

ADAMTS12 Show »« Hide

Nomenclature	ADAMTS12
Other names	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12, Adamts12_predicted, LOC294809, A disintegrin and metalloproteinase with thrombospondin motifs 12, ADAM metallopeptidase with thrombospondin type 1 motif, 12, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 (predicted), a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 (predicted)
Genes	ADAMTS12 (Hs), Adamts12 (Mm), Adamts12 (Rn)
Ensembl ID	ENSG00000151388 (Hs), ENSMUSG00000047497 (Mm), ENSRNOG00000018865 (Rn)

ADAMTS13 Show »« Hide

Nomenclature	ADAMTS13
Other names	von Willebrand factor-cleaving protease, vWF-CP, C9orf8, VWFCP, TTP, FLJ42993, MGC118899, MGC118900, DKFZp434C2322, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13, LOC362091, Adamts13_predicted, A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM metallopeptidase with thrombospondin type 1 motif, 13, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 (predicted), a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 (predicted), LOC279028, vWF-CP mRNA for von Willebrand factor-cleaving
Genes	ADAMTS13 (Hs), Adamts13 (Mm), Adamts13 (Rn)
Ensembl ID	ENSG00000160323 (Hs), ENSMUSG00000014852 (Mm)
Comment	Loss-of-function mutations of autoimmune antibodies are associated with thrombotic thrombocytopenic purpura

ADAMTS14 Show »« Hide

Nomenclature	ADAMTS14
Other names	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14, Adamts14_predicted, LOC309837, A disintegrin and metalloproteinase with thrombospondin motifs 14, ADAM metallopeptidase with thrombospondin type 1 motif, 14, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 (predicted), a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14 (predicted), Adamts-14, TS14
Genes	ADAMTS14 (Hs), Adamts14 (Mm), Adamts14 (Rn)
Ensembl ID	ENSG00000138316 (Hs), ENSMUSG00000059901 (Mm), ENSRNOG00000000563 (Rn)

ADAMTS15 Show »« Hide

Nomenclature	ADAMTS15
Other names	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15, Adamts15_predicted, LOC300474, A disintegrin and metalloproteinase with thrombospondin motifs 15, ADAM metallopeptidase with thrombospondin type 1 motif, 15, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15 (predicted), a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15 (predicted)
Genes	ADAMTS15 (Hs), Adamts15 (Mm), Adamts15 (Rn)
Ensembl ID	ENSG00000166106 (Hs), ENSMUSG00000033453 (Mm), ENSRNOG00000009892 (Rn)

ADAMTS16 Show »« Hide

Nomenclature	ADAMTS16
Other names	ADAMTS16s, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16, Adamts16_predicted, LOC306664, A disintegrin and metalloproteinase with thrombospondin motifs 16, ADAM metallopeptidase with thrombospondin type 1 motif, 16, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16 (predicted), a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16 (predicted)
Genes	ADAMTS16 (Hs), Adamts16 (Mm), Adamts16 (Rn)
Ensembl ID	ENSG00000145536 (Hs), ENSMUSG00000049538 (Mm)

ADAMTS17 Show »« Hide

Nomenclature	ADAMTS17
Other names	FLJ32769, FLJ16363, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17, Adamts17_predicted, LOC293004, A disintegrin and metalloproteinase with thrombospondin motifs 17, ADAM metallopeptidase with thrombospondin type 1 motif, 17, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17 (predicted), AU023434
Genes	ADAMTS17 (Hs), Adamts17 (Mm), Adamts17 (Rn)
Ensembl ID	ENSG00000140470 (Hs), ENSMUSG00000058145 (Mm), ENSRNOG00000037080 (Rn)

ADAMTS18 Show »« Hide

Nomenclature	ADAMTS18
Other names	ADAMTS21, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18, LOC361412, RGD1560118, RGD1560118_predicted, A disintegrin and metalloproteinase with thrombospondin motifs 18, ADAM metallopeptidase with thrombospondin type 1 motif, 18, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18, similar to a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 isoform 1 preproprotein, similar to a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 isoform 1 preproprotein (predicted)
Genes	ADAMTS18 (Hs), Adamts18 (Mm), Adamts18 (Rn)
Ensembl ID	ENSG00000140873 (Hs), ENSMUSG00000053399 (Mm), ENSRNOG00000011575 (Rn)

ADAMTS19 Show »« Hide

Nomenclature	ADAMTS19
Other names	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 19, Adamts19_predicted, LOC361332, A disintegrin and metalloproteinase with thrombospondin motifs 19, ADAM metallopeptidase with thrombospondin type 1 motif, 19, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19 (predicted), a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 19 (predicted)
Genes	ADAMTS19 (Hs), Adamts19 (Mm), Adamts19 (Rn)
Ensembl ID	ENSG00000145808 (Hs), ENSMUSG00000053441 (Mm), ENSRNOG00000019577 (Rn)

ADAMTS20 Show »« Hide

Nomenclature	ADAMTS20
Other names	GON-1, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 20, Adamts20_predicted, LOC315263, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20 (predicted), a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 20 (predicted), ADAMTS-20, bt
Genes	ADAMTS20 (Hs), Adamts20 (Mm), Adamts20 (Rn)
Ensembl ID	ENSG00000173157 (Hs), ENSMUSG00000022449 (Mm)

PAPLN Show »« Hide

Nomenclature	PAPLN
Other names	Papilin, MGC50452, LOC314297, Papln_predicted, papilin, proteoglycan-like sulfated glycoprotein, papilin, proteoglycan-like sulfated glycoprotein (predicted)
Genes	PAPLN (Hs), Papln (Mm), Papln (Rn)
Ensembl ID	ENSG00000100767 (Hs), ENSMUSG00000021223 (Mm)

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