Interleukin-1 receptor-associated kinase (IRAK) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The IRAK family consists of four members, IRAK1, IRAK2, IRAK3 (also known as IRAK-M) and IRAK4. Only IRAK1 and IRAK4 have verified kinase activity [3]. Whilst IRAKs 1, 2 and 4 are ubiquitously expressed, IRAK3 expression is restricted to monocytes and macrophages. IRAKs are key components of the IL-1 receptor and Toll-like receptor signalling pathways of the innate immune response.

Enzymes

IRAK1 (interleukin 1 receptor associated kinase 1) Show summary » More detailed page

IRAK2 (interleukin 1 receptor associated kinase 2) Show summary » More detailed page

IRAK3 (interleukin 1 receptor associated kinase 3) Show summary » More detailed page

IRAK4 (interleukin 1 receptor associated kinase 4) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Interleukin-1 receptor-associated kinase (IRAK) family. Accessed on 29/09/2016. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=579.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.