1.13.11.- Dioxygenases

Home
Targets
Enzymes
1.13.11.- Dioxygenases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

IDO1 (indoleamine 2,3-dioxygenase 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2829

Nomenclature

indoleamine 2,3-dioxygenase 1

Common abbreviation

IDO1

Previous and unofficial names

INDO | indoleamine-pyrrole 2,3 dioxygenase | IDO-1 | IDO | indoleamine 2

Genes

IDO1 (Hs), Ido1 (Mm), Ido1 (Rn)

Ensembl ID

ENSG00000131203 (Hs), ENSMUSG00000031551 (Mm), ENSRNOG00000031189 (Rn)

UniProtKB AC

P14902 (Hs), P28776 (Mm), Q9ERD9 (Rn)

EC number

1.13.11.52

IDO2 (indoleamine 2,3-dioxygenase 2) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

3019

Nomenclature

indoleamine 2,3-dioxygenase 2

Common abbreviation

IDO2

Previous and unofficial names

indoleamine 2 | INDOL1 | indoleamine-pyrrole 2,3 dioxygenase-like 1

Genes

IDO2 (Hs), Ido2 (Mm), Ido2 (Rn)

Ensembl ID

ENSG00000188676 (Hs), ENSMUSG00000031549 (Mm), ENSRNOG00000025365 (Rn)

UniProtKB AC

Q6ZQW0 (Hs), Q8R0V5 (Mm)

EC number

1.13.11.52
D-tryptophan + O(2) <=> N-formyl-D-kynurenine L-tryptophan + O(2) <=> N-formyl-L-kynurenine

TDO2 (tryptophan 2,3-dioxygenase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2887

Nomenclature

tryptophan 2,3-dioxygenase

Common abbreviation

TDO2

Previous and unofficial names

Genes

TDO2 (Hs), Tdo2 (Mm), Tdo2 (Rn)

Ensembl ID

ENSG00000151790 (Hs), ENSMUSG00000028011 (Mm), ENSRNOG00000011612 (Rn)

UniProtKB AC

P48775 (Hs), P48776 (Mm), P21643 (Rn)

EC number

1.13.11.11
Together with IDO1, catalyzes the first and rate-limiting step in the kynurenine pathway (major pathway of tryptophan metabolism). L-tryptophan + O₂ <=> N-formyl-L-kynurenine

How to cite this family page

Database page citation:

1.13.11.- Dioxygenases. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=899.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.