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This section concentrates on those pattern recognition receptors (PRRs) encoded by the human genome which are non-catalytic DNA-sensing proteins. Like other PRRs, these proteins facilitate the induction of an innate immune response upon detection of pathogens, via a variety of signalling pathways.
Catalytic receptor PRRs included in the Guide To PHARMACOLOGY are:
Toll-like receptors (TLRs)
Nucleotide-binding oligomerization domain-like receptors (NLRs, also known as NOD-like receptors), and
RIG-I-like receptors (RLRs)
Database page citation:
Non-catalytic pattern recognition receptors. Accessed on 24/04/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=941.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 172: 5729-5743.