NOD-like receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

« Hide

The nucleotide-binding oligomerization domain, leucine-rich repeat (NLR) family of receptors (nomenclature recommended by the NC-IUPHAR subcommittee on pattern recognition receptors [1]) share a common domain organisation. This consists of an N-terminal effector domain, a central nucleotide-binding and oligomerization domain (NOD; also referred to as a NACHT domain), and C-terminal leucine-rich repeats (LRR) which have regulatory and ligand recognition functions. The type of effector domain has resulted in the division of NLR family members into two major sub-families, NLRC and NLRP, along with three smaller sub-families NLRA, NLRB and NLRX [7]. NLRC members express an N-terminal caspase recruitment domain (CARD) and NLRP members an N-terminal Pyrin domain (PYD).

Upon activation the NLRC family members NOD1 (NLRC1) and NOD2 (NLRC2) recruit a serine/threonine kinase RIPK2 (receptor interacting serine/threonine kinase 2, O43353, also known as CARD3, CARDIAK, RICK, RIP2) leading to signalling through NFκB and MAP kinase. Activation of NLRC4 (previously known as IPAF) and members of the NLRP3 family, including NLRP1 and NLRP3, leads to formation of a large multiprotein complex known as the inflammasome. In addition to NLR proteins other key members of the inflammasome include the adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD, also known as PYCARD, CARD5, TMS1, Q9ULZ3) and inflammatory caspases. The inflammasome activates the pro-inflammatory cytokines IL-1β (IL1B, P01584) and IL-18 (IL18, Q14116) [1,3].

Receptors

NOD1 (nucleotide-binding oligomerization domain containing 1) Show summary » More detailed page

NOD2 (nucleotide-binding oligomerization domain containing 2) Show summary » More detailed page

NLRC3 Show summary » More detailed page

NLRC4 Show summary » More detailed page

NLRC5 Show summary » More detailed page

NLRX1 Show summary » More detailed page

CIITA Show summary » More detailed page

NLRP1 Show summary » More detailed page

NLRP2 Show summary » More detailed page

NLRP3 Show summary » More detailed page

NLRP4 Show summary » More detailed page

NLRP5 Show summary » More detailed page

NLRP6 Show summary » More detailed page

NLRP7 Show summary » More detailed page

NLRP8 Show summary » More detailed page

NLRP9 Show summary » More detailed page

NLRP10 Show summary » More detailed page

NLRP11 Show summary » More detailed page

NLRP12 Show summary » More detailed page

NLRP13 Show summary » More detailed page

NLRP14 Show summary » More detailed page

Comments

Show »

Further reading

Show »

References

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation:

Clare Bryant, Tom Monie. NOD-like receptor family. Accessed on 02/09/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=317.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Catalytic Receptors. Br J Pharmacol. 170: 1676–1705.