NOD-like receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Structural analysis has identified a common motif of a mid-peptide located nucleotide-binding and oligomerization (NACHT) domain, which allows division of NOD-like receptors into three subfamilies, NLRC (or NODs), NLRP (or NALP) and IPAF [3]. NLRC members are named on the basis of a sequence motif expressed at their N-termini, the caspase recruitment domain (CARD), while NLRP members have a pyrin domain. NLRs express C-terminal leucine-rich regions which have regulatory function and appear to recognize the microbial products to which the NLRs respond. NLRC family members recruit a serine/threonine kinase RIPK2 (receptor-interacting serine/threonine kinase 2, O43353, also known as CARD3, CARDIAK, RICK, RIP2) leading to signalling through NFκB and MAP kinase. NLRP family members, upon activation, recruit adaptor proteins (e.g. ASC, also known as PYCARD, CARD5, TMS-1, Q9ULZ3). Activated NLRs associate in multiprotein complexes, known as inflammasomes [3], allowing the recruitment of caspases.


NLRC1 Show summary »

NLRC2 Show summary »

NLRC3 Show summary »

NLRC5 Show summary »

NLRX1 Show summary »

CIITA Show summary »

NLRP1 Show summary »

NLRP2 Show summary »

NLRP3 Show summary » More detailed page

NLRP4 Show summary »

NLRP5 Show summary »

NLRP6 Show summary »

NLRP7 Show summary »

NLRP8 Show summary »

NLRP9 Show summary »

NLRP10 Show summary »

NLRP11 Show summary »

NLRP12 Show summary »

NLRP13 Show summary »

NLRP14 Show summary »

IPAF Show summary »


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How to cite this family page

Database page citation:

NOD-like receptor family. Accessed on 28/07/2015. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Catalytic Receptors. Br J Pharmacol. 170: 1676–1705.