RIG-I-like receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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There are three human RIG-I-like receptors (RLRs) which are cytoplasmic pattern recognition receptors (PRRs) of the innate immune system. They detect non-self cytosolic double-stranded RNA species from various sources and are essential for inducing production of the type I interferon, IFNβ, and other anti-pathogenic effectors [1-2].

Receptors

RIG-1 (DExD/H-box helicase 58) Show summary »« Hide summary More detailed page

Target Id

2920

Nomenclature

DExD/H-box helicase 58

Common abbreviation

RIG-1

Previous and unofficial names

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | retinoic acid inducible gene I | RNA helicase RIG-I

Genes

DDX58 (Hs), Ddx58 (Mm), Ddx58 (Rn)

Ensembl ID

ENSG00000107201 (Hs), ENSMUSG00000040296 (Mm), ENSRNOG00000006384 (Rn)

UniProtKB AC

O95786 (Hs), Q6Q899 (Mm)

EC number

3.6.4.13
RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate

MDA5 (interferon induced with helicase C domain 1) Show summary »« Hide summary More detailed page

Target Id

2921

Nomenclature

interferon induced with helicase C domain 1

Common abbreviation

MDA5

Previous and unofficial names

melanoma differentiation-associated gene 5 | MDA-5

Genes

IFIH1 (Hs), Ifih1 (Mm), Ifih1 (Rn)

Ensembl ID

ENSG00000115267 (Hs), ENSMUSG00000026896 (Mm), ENSRNOG00000006227 (Rn)

UniProtKB AC

Q9BYX4 (Hs), Q8R5F7 (Mm)

EC number

3.6.4.13
RNA helicase; uses the energy from ATP to unwind RNA ATP + H(2)O <=> ADP + phosphate

LGP2 (DExH-box helicase 58) Show summary »« Hide summary More detailed page

Target Id

2922

Nomenclature

DExH-box helicase 58

Common abbreviation

LGP2

Previous and unofficial names

DEXH (Asp-Glu-X-His) box polypeptide 58 | RNA helicase LGP2

Genes

DHX58 (Hs), Dhx58 (Mm), Dhx58 (Rn)

Ensembl ID

ENSG00000108771 (Hs), ENSMUSG00000017830 (Mm), ENSRNOG00000018247 (Rn)

UniProtKB AC

Q96C10 (Hs)

EC number

3.6.4.13
RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate

References

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How to cite this family page

Database page citation:

RIG-I-like receptor family. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=940.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.