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RIG-I-like receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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There are three human RIG-I-like receptors (RLRs) which are cytoplasmic pattern recognition receptors (PRRs) of the innate immune system. They detect non-self cytosolic double-stranded RNA species from various sources and are essential for inducing production of the type I interferon, IFNβ, and other anti-pathogenic effectors [1-2].


RIG-1 (DExD/H-box helicase 58) Show summary » More detailed page

MDA5 (interferon induced with helicase C domain 1) Show summary » More detailed page

LGP2 (DExH-box helicase 58) Show summary » More detailed page


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Clare Bryant, Tom Monie. RIG-I-like receptor family. Accessed on 21/03/2019. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Catalytic receptors. Br J Pharmacol. 174 Suppl 1: S225-S271.