ChEMBL ligand: CHEMBL1086218 (Amdray, PSC 833, SDZ PSC 833, SDZ-PSC 833, Valspodar)
ABCC2/Canalicular multispecific organic anion transporter 1 in Human [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887] There should be some charts here, you may need to enable JavaScript!
ABCC1/Multidrug resistance-associated protein 1 in Human [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCC2/Canalicular multispecific organic anion transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887]
ChEMBL	TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from MRP2-expressing LLC PK1 cells	F	4.54	pKi	28900	nM	Ki	Mol Pharmacol (1999) 56: 1219-1228 [PMID:10570049]
ABCC1/Multidrug resistance-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527]
ChEMBL	TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicle from MRP1-expressing HeLa cells	F	4.57	pKi	27000	nM	Ki	J Biol Chem (1994) 269: 27807-27810 [PMID:7961706]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	TP_TRANSPORTER: inhibition of Calcein-AM efflux in CEM/VBL 100 cells	F	5.89	pKi	1300	nM	Ki	Biochem Biophys Res Commun (1999) 257: 410-413 [PMID:10198227]
GtoPdb	-	-	5.89	pKi	1300	nM	Ki	Biochem Biophys Res Commun (1999) 257: 410-3 [PMID:10198227]
ChEMBL	TP_TRANSPORTER: inhibition of ATPase activity (Verapamil) in P-gp-MRP-16-Protein A complex	F	6.87	pKi	134	nM	Ki	Br J Pharmacol (1997) 122: 241-248 [PMID:9313931]
ChEMBL	TP_TRANSPORTER: inhibition of Vinblastine transepithelial transport (basal to apical) (Vinblastine: 0.1 uM) in MDR1-expressing LLC-PK1 cells	F	5.97	pIC50	1060	nM	IC50	Jpn J Cancer Res (1998) 89: 1220-1228 [PMID:9914792]
ChEMBL	Inhibition of P-glycoprotein-mediated daunorubicin efflux from human CCRF-CEM/VCR1000 cells after 240 secs by FACS flow cytometric analysis	B	6.3	pIC50	501.19	nM	IC50	J Med Chem (2012) 55: 3261-3273 [PMID:22452412]
ChEMBL	TP_TRANSPORTER: inhibition of Doxorubicin transepithelial transport (basal to apical) (Doxorubicin: 0.8 uM) in MDR1-expressing LLC-PK1 cells	F	6.54	pIC50	291	nM	IC50	Jpn J Cancer Res (1998) 89: 1220-1228 [PMID:9914792]
ChEMBL	TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells	F	6.96	pIC50	110	nM	IC50	Drug Metab Dispos (2000) 28: 655-660 [PMID:10820137]
ChEMBL	TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cells	F	7.65	pIC50	22.2	nM	IC50	Drug Metab Dispos (2000) 28: 1238-1243 [PMID:10997946]
ChEMBL	TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: 0.25 uM) in MDR-CEM cells	F	6.39	pEC50	410	nM	EC50	Anticancer Drugs (1996) 7: 568-578 [PMID:8862725]
ChEMBL	TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: 0.25 uM) in MDR-P388 cells	F	6.96	pEC50	110	nM	EC50	Anticancer Drugs (1996) 7: 568-578 [PMID:8862725]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]