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ChEMBL ligand: CHEMBL219162 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
ChEMBL | Inhibition of human NK1 receptor | B | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] | ||||||||
ChEMBL | Inhibition of human NK2 receptor | B | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
NK3 receptor/Neurokinin 3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4429] [GtoPdb: 362] [UniProtKB: P29371] | ||||||||
ChEMBL | Activity at human NK3 receptor assessed as inhibition of senktide-induced calcium mobilization in CHO cells at 2.8 uM | F | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
ChEMBL | Activity at human NK3 receptor assessed as inhibition of senktide-stimulated inositol phosphate generation in CHO cells | F | 7.55 | pIC50 | 28 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
ChEMBL | Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cells | B | 8.06 | pIC50 | 8.8 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
ChEMBL | Binding affinity to gerbil NK3 receptor | B | 8.35 | pIC50 | 4.5 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
GtoPdb | - | - | 8.4 | pIC50 | - | - | - | Bioorg Med Chem Lett (2006) 16: 5748-51 [PMID:16950620] |
NK3 receptor/Neurokinin 3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3154] [GtoPdb: 362] [UniProtKB: P16177] | ||||||||
ChEMBL | Binding affinity to rat NK3 receptor | B | 7.18 | pIC50 | 66 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]