NK3 receptor

Target id: 362

Nomenclature: NK3 receptor

Family: Tachykinin receptors

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Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 465 4q25 TACR3 tachykinin receptor 3 49
Mouse 7 452 3 H2 Tacr3 tachykinin receptor 3 99
Rat 7 452 2q42-q44 Tacr3 tachykinin receptor 3 87
Previous and Unofficial Names
Neurokinin B receptor
neurokinin beta receptor
Nmkr
Tac3r
neuromedin K receptor
NK-3 receptor
SP-N receptor
Database Links
Specialist databases
GPCRDB nk3r_human (Hs), nk3r_mouse (Mm), nk3r_rat (Rn)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
neurokinin A {Sp: Human, Mouse, Rat}
neurokinin B {Sp: Human, Mouse, Rat, Pig}
substance P {Sp: Human, Mouse, Rat}
Comments: Neurokinin B is the highest potency endogenous agonist
Potency order of endogenous ligands (Human)
neurokinin B (TAC3, Q9UHF0) > neurokinin A (TAC1, P20366) > substance P (TAC1, P20366)

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
senktide Rn Full agonist 7.9 – 9.1 pKd 11,56
pKd 7.9 – 9.1 (Kd 1.2x10-8 – 9x10-10 M) [11,56]
[3H]senktide Cp Full agonist 8.1 – 8.7 pKd 44
pKd 8.1 – 8.7 (Kd 8.52x10-9 – 2.21x10-9 M) [44]
hemokinin 1 {Sp: Mouse} Mm Full agonist 9.2 – 9.3 pKi 82
pKi 9.2 – 9.3 [82]
[Phe(Me)7]neurokinin B Mm Full agonist 9.2 pKi 82
pKi 9.2 [82]
[Phe(Me)7]neurokinin B Hs Full agonist 8.7 – 9.6 pKi 82,84
pKi 8.7 – 9.6 [82,84]
hemokinin 1 {Sp: Mouse} Hs Full agonist 8.6 – 9.1 pKi 82
pKi 8.6 – 9.1 [82]
neurokinin B {Sp: Human, Mouse, Rat, Pig} Mm Full agonist 8.6 – 8.7 pKi 82
pKi 8.6 – 8.7 [82]
neurokinin B {Sp: Human, Mouse, Rat, Pig} Hs Full agonist 7.7 – 9.2 pKi 82,84
pKi 7.7 – 9.2 [82,84]
senktide Hs Full agonist 7.1 – 8.6 pKi 82,84,101
pKi 7.1 – 8.6 [82,84,101]
senktide Mm Full agonist 7.6 – 8.0 pKi 82
pKi 7.6 – 8.0 [82]
neurokinin A {Sp: Human, Mouse, Rat} Mm Full agonist 6.1 pKi 82
pKi 6.1 [82]
neurokinin A {Sp: Human, Mouse, Rat} Hs Full agonist 5.5 – 6.3 pKi 82,84
pKi 5.5 – 6.3 [82,84]
substance P {Sp: Human, Mouse, Rat} Hs Full agonist 5.0 – 6.0 pKi 82,84
pKi 5.0 – 6.0 [82,84]
substance P {Sp: Human, Mouse, Rat} Mm Full agonist 5.3 pKi 82
pKi 5.3 [82]
senktide Cp Agonist 9.3 pEC50 107
pEC50 9.3 (EC50 5x10-10 M) [107]
[Phe(Me)7]neurokinin B Hs Full agonist 8.9 pEC50 15,24
pEC50 8.9 (EC50 1.3x10-9 M) [15,24]
neurokinin B {Sp: Human, Mouse, Rat, Pig} Hs Full agonist 8.4 pEC50 11,24
pEC50 8.4 (EC50 4x10-9 M) [11,24]
senktide Rn Full agonist 7.9 – 8.8 pEC50 56
pEC50 7.9 – 8.8 (EC50 1.2x10-8 – 1.5x10-9 M) [56]
neurokinin A {Sp: Human, Mouse, Rat} Hs Full agonist 7.4 pEC50 11
pEC50 7.4 (EC50 4x10-8 M) [11]
kassinin Hs Full agonist 6.7 – 7.0 pIC50 101
pIC50 6.7 – 7.0 [101]
[Pro7]neurokinin B Hs Full agonist 6.4 – 6.6 pIC50 101
pIC50 6.4 – 6.6 [101]
eledoisin Hs Full agonist 6.2 – 6.6 pIC50 11,101
pIC50 6.2 – 6.6 (IC50 5.894x10-7 – 2.642x10-7 M) [11,101]
[125I][MePhe7]NKB Hs Full agonist - -
View species-specific agonist tables
Agonist Comments
Affinity data for guinea pig tachykinin receptors has been included as this species more closely mimics human tachykinin receptor expression pattern, gene sequence, and receptor function than do the rat or mouse.
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[Trp7, β-Ala8] neurokinin A-(4-10) Rn Antagonist 7.5 pA2 24
pA2 7.5 [24]
[3H]osanetant Hs Antagonist 9.9 pKd
pKd 9.9 (Kd 1.3x10-10 M)
osanetant Cp Antagonist 10.0 pKi 28
pKi 10.0 (Ki 1.1x10-10 M) [28]
SSR 146977 Hs Antagonist 9.6 pKi 29
pKi 9.6 [29]
SCH 206272 Hs Antagonist 9.5 pKi 2
pKi 9.5 [2]
osanetant Hs Antagonist 8.4 – 9.7 pKi 2,6,15,28,52,72,82,84,101
pKi 8.4 – 9.7 [2,6,15,28,52,72,82,84,101]
GSK 256471 Hs Antagonist 9.0 pKi 90
pKi 9.0 [90]
SB 235375 Hs Antagonist 8.7 pKi 48
pKi 8.7 (Ki 2.2x10-9 M) [48]
AZD2624 Hs Antagonist 8.7 pKi 3
pKi 8.7 (Ki 2x10-9 M) [3]
FK 224 Hs Antagonist 8.2 – 8.4 pKi 67
pKi 8.2 – 8.4 [67]
talnetant Hs Antagonist 7.4 – 9.0 pKi 7,39,82,84
pKi 7.4 – 9.0 [7,39,82,84]
GSK 172981 Cp Antagonist 8.1 pKi 23
pKi 8.1 (Ki 7.8x10-9 M) [23]
GSK 256471 Cp Antagonist 8.1 pKi 23
pKi 8.1 (Ki 8.4x10-9 M) [23]
GSK 172981 Hs Antagonist 8.0 pKi 90
pKi 8.0 [90]
PD157672 Hs Antagonist 7.8 – 8.0 pKi 15
pKi 7.8 – 8.0 [15]
SB 218795 Hs Antagonist 7.8 – 8.0 pKi 39
pKi 7.8 – 8.0 (Ki 1.6x10-8 – 1.06x10-8 M) [39]
SB 222200 Hs Antagonist 6.6 – 8.4 pKi 82-83
pKi 6.6 – 8.4 [82-83]
PD 154740 Hs Antagonist 7.4 pKi 15
pKi 7.4 (Ki 4x10-8 M) [15]
talnetant Rn Antagonist 7.3 – 7.4 pKi 82
pKi 7.3 – 7.4 [82]
GR138676 Hs Antagonist 6.0 pKi 91
pKi 6.0 [91]
saredutant Hs Antagonist 5.7 – 6.2 pKi 2,84
pKi 5.7 – 6.2 [2,84]
N',2-diphenylquinoline-4-carbohydrazide 8m Hs Antagonist 8.4 pIC50 27
pIC50 8.4 [27]
N′,2-diphenylquinoline-4-carbohydrazide Hs Antagonist 7.9 – 8.4 pIC50 26
pIC50 7.9 – 8.4 [26]
PD 161182 Hs Antagonist 8.1 pIC50 8
pIC50 8.1 (IC50 7x10-9 M) [8]
osanetant Hs Antagonist 7.9 – 8.0 pIC50 15
pIC50 7.9 – 8.0 (IC50 1.2x10-8 – 1x10-8 M) [15]
PD157672 Hs Antagonist 7.8 – 7.9 pIC50 8,101
pIC50 7.8 – 7.9 (IC50 1.6x10-8 – 1.21x10-8 M) [8,101]
SB 222200 Hs Antagonist 7.7 pIC50 83
pIC50 7.7 (IC50 1.84x10-8 M) [83]
saredutant Hs Antagonist 6.5 pIC50 16
pIC50 6.5 (IC50 3.5x10-7 M) [16]
PD 154740 Hs Antagonist 6.2 – 6.2 pIC50 15
pIC50 6.2 – 6.2 (IC50 6.8x10-7 – 5.8x10-7 M) [15]
View species-specific antagonist tables
Antagonist Comments
Affinity data for guinea pig tachykinin receptors has been included as this species more closely mimics human tachykinin receptor expression pattern, gene sequence, and receptor function than do the rat or mouse.

SR48968 is an inhibitor in guinea pigs but not in rats, where it is specific for NK2 receptor. Two amino acids in the first and second transmembrane domains are responsible for differences in species specificity. In addition, SR48968 is a non-selective antagonist in that it can antagonize the NK1 and NK2 receptors in humans and guinea pigs as well. SR 142801 appears to have an effect on all tachykinin receptors to varying degrees with the concentration for inhibition greatly exceeding that of inhibitors specific to these receptors. SR 142801 is specific to the NK3 receptor as the Ki is less than 1nM. PD154740 and PD157672 display a similiar species specificity. PD157672 and PD161182 are peptide derived antagonists.
Primary Transduction Mechanisms
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  98
Tissue Distribution
Hypothalamus.
Species:  Human
Technique:  RT-PCR.
References:  11
Kidney.
Species:  Human
Technique:  RT-PCR.
References:  11
Total human embryo.
Species:  Human
Technique:  RT-PCR.
References:  11
Placenta.
Species:  Human
Technique:  RT-PCR.
References:  11
Hippocampus.
Species:  Human
Technique:  RT-PCR.
References:  11
Frontal cortex, temporal cortex, parietal cortex.
Species:  Human
Technique:  RT-PCR.
References:  11
Locus niger.
Species:  Human
Technique:  RT-PCR.
References:  11
Brain; glia limitans at the pial surface (astrocytes and beaded fibres), all cortical layers, white matter (astrocytes and beaded fibres, particularly surrounding blood vessels).
Species:  Human
Technique:  Immunohistochemistry.
References:  103
Sigmoid colon: gastro myenteric and submucosal plexus.
Species:  Human
Technique:  Immunohistochemistry.
References:  22
Prefrontal and visual cortex; beaded fibres and cells with astrocyte-like morphology in the superficial cortical layers and white matter, dots in the neuropil and on pyramidal (layers III/V) and non-pyramidal (layers V/VI) cells.
Species:  Human
Technique:  Immunohistochemistry.
References:  102
Striatum.
Species:  Human
Technique:  RT-PCR.
References:  11
Striatum; nitric oxide synthase/preprosomatostatin containing GABAergic interneurones.
Species:  Mouse
Technique:  in situ hybridization.
References:  77
Smooth muscle cells of the esophagus, stomach, and intestines. Submucousal nerve plexus or myenteric nerve plexus of the gastrointestinal tract except for the esophagus, stomach and rectum.
Species:  Mouse
Technique:  Unspecified
References:  42,106
Mouse ileum; neurons and interstitial cells of Cajal at the deep muscular plexus, inner portion of the circular muscle layer.
Species:  Mouse
Technique:  Immunohistochemistry.
References:  105
Kidney.
Species:  Rat
Technique:  Autoradiography.
References:  14
Portal vein.
Species:  Rat
Technique:  Organ bath physiological measurement.
References:  64
Mid-cortical layers.
Species:  Rat
Technique:  Radioligand binding.
References:  21
Supraoptic nucleus.
Species:  Rat
Technique:  Radioligand binding.
References:  21
Zona incerta.
Species:  Rat
Technique:  Radioligand binding.
References:  21
Amygdala.
Species:  Rat
Technique:  Radioligand binding.
References:  21
Substantia nigra pars compacta.
Species:  Rat
Technique:  Radioligand binding.
References:  21
Ventral tegumental area.
Species:  Rat
Technique:  Radioligand binding.
References:  21
Hippocampus.
Species:  Rat
Technique:  Radioligand binding.
References:  21
Hypothalamus.
Species:  Rat
Technique:  Radioligand binding.
References:  21
Uterus.
Species:  Rat
Technique:  Autoradiography.
References:  5
Pancreatic acini.
Species:  Rat
Technique:  immunocytochemistry.
References:  9
Spinal cord; lamina II (dendritic spines inside glomeruli, preterminal axons and axon terminals) and lamina X.
Species:  Rat
Technique:  immunocytochemistry.
References:  109
Mid-cortical layer of cortex: cingulate cortex > frontoparietal cortex > retrosplenial cortex.

Basal ganglia: caudate putamen, anterior.

Zona incerta.

Hypothalamus: paraventricular nucleus > supraoptic nucleus > dorsomedial hypothalamus nucleus > supramammillary nucleus.

Medial habenula.

Amygdala: basolateral amygdaloid nucleus > basomedial amygdaloid nucleus > amygdalohippocampal area.

Hippocampus: CA3, vetral.

Midbrain: ventral tagmental area > interpeduncular nucleus > substantia nigra, pars compacta > median raphe nucleus > superior colliculus.

Pons: sphenoid nucleus > posterodorsal tagmental nucleus.
Species:  Rat
Technique:  Autoradiography.
References:  55,96
Nucleus tractus solitarius and dorsal vagal motor neurone regions of the brainstem.
Species:  Rat
Technique:  Immunohistochemistry.
References:  65
Cortex, amygdala, hippocampus, medial habenula, zona incerta, paraventricular and supraoptic nuclei of the hypothalamus, substantia nigra, ventral tegmental area, interpeduncular nucleus, raphe nuclei, dorsal tegmental nucleus, nucleus of the solitary tract, olfactory bulb, dentate gyrus and subiculum, medial septum, diagonal band of Broca, ventral pallidum, globus pallidus, bed nucleus of the stria terminalis, arcuate, premammillary and mammillary nuclei, dorsal and lateral regions of the posterior hypothalamus, central gray, cerebellum, parabrachial nuclei, nucleus of the spinal trigeminal tract, dorsal horn of the spinal cord, retina.
Species:  Rat
Technique:  in situ hybridization.
References:  88
Gustatory centers; rostral nucleus of the solitary tract, caudal half of dorsocentral zone, external medial subnucleus.
Species:  Rat
Technique:  Immunohistochemistry.
References:  47
Blood vessels in oral tissues.
Species:  Rat
Technique:  Immunohistochemistry.
References:  37
Brainstem auditory nuclei; cochlear nucleus, lateral superior olive, the medial nucleus of the trapezoid body, and inferior colliculus.
Species:  Rat
Technique:  Immunohistochemistry.
References:  46
Duodemum, ileum, colon, rectum; myenteric plexus > submucous plexus.
Species:  Rat
Technique:  Immunohistochemistry.
References:  62
Lateral hypothalamus and the zona incerta; melanin-concentrating hormone (MCH) neurons.
Species:  Rat
Technique:  Immunocytochemistry, in situ hybridization.
References:  43
Dorsal vagal complex.
Species:  Rat
Technique:  immunocytochemistry.
References:  12
Paraventricular nucleus (magnocellular part) and hypothalamus (supraoptic nucleus).
Species:  Rat
Technique:  Autoradiography, in situ hybridization.
References:  25
Medial habenula nucleus.
Species:  Rat
Technique:  Extracellular recording.
References:  70
Mysenteric plexus of the ileum.
Species:  Guinea pig
Technique:  Radioligand binding.
References:  44
Tissue Distribution Comments
The rat portal vein is the preferred tissue for the assay of NK3 receptors as guinea pig ileum expresses NK1 receptors limiting its use in contractile studies designed to investigate the pharmacology of the NK3 receptor.
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of intracellular Ca2+ in CHO cells transfected with the human NK3 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Increase in intracellular Ca2+.
References:  75
Physiological Functions
Involved in interleukin-1β-induced NGF release and airway hyperresponsiveness.
Species:  Human
Tissue:  Isolated human bronchi.
References:  69
Stimulation of amylase secretion in isolated rat pancreatic acini.
Species:  Rat
Tissue:  Pancreatic acini.
References:  61
Enhancement of substance P release from capsaicin-sensitive spinal cord afferent terminals.
Species:  Rat
Tissue:  In vivo.
References:  85
Involvement in intestinal and somatic nociceptive responses and intestinal motility in anaesthetized rats.
Species:  Rat
Tissue:  In vivo.
References:  86
A subpopulation of dopamine-sensitive neurones in the substantia nigra zona compacta are potently excited by an NK3 receptor agonist.
Species:  Rat
Tissue:  Substantia nigra zona compacta.
References:  54
Locomotion, rearing and sniffing are observed following infusion of an NK3 agonist into the substantia nigra pars compacta, and to a lesser extent in the ventral tegmental area. Yawning, chewing mouth movements and wet dog shakes are seen following infusion of an NK3 agonist into the ventral tegmental area.
Species:  Rat
Tissue:  In vivo.
References:  97
Following intracisternal administration NK3 agonists cause behaviour typically associated with serotonergic stimulation, including head twitches, reciprocal forepaw treading and hindlimb splaying.
Species:  Mouse
Tissue:  In vivo.
References:  95
Intraventricular injections of an NK3 agonist suppress the ingestion of hypertonic NaCl aqueous solution.
Species:  Rat
Tissue:  In vivo.
References:  32,34-36,76,89
Mediation of the baroreflex function.
Species:  Rat
Tissue:  In vivo.
References:  33
Alterations in luteinizing hormone secretion.
Species:  Rat
Tissue:  In vivo.
References:  81
Centrally administered NK3 antagonists cause a sustained and dose-dependent reduction of blood pressure in hypertensive rats.
Species:  Rat
Tissue:  In vivo.
References:  59
Modulation of inflammation in experimentally-induced colitis in rats.
Species:  Rat
Tissue:  In vivo.
References:  51
Endogenous NK3 activity in the substantia nigra maintains high blood pressure in spontaneously hypertensive rats.
Species:  Rat
Tissue:  In vivo.
References:  58
NK3 receptor activation induces neuronal bursting.
Species:  Rat
Tissue:  Isolated neonatal spinal cord.
References:  45,63
Antidepressant-type effects; in forced swim tests in mouse lines selectively bred for divergent magnitudes of stress-induced analgesia, NK3 activation reduced immobility more in opioid receptor-dense high analgesia lines than in unselected mice, but was ineffective in the opioid receptor-deficient low analgesia line.
Species:  Mouse
Tissue:  In vivo.
References:  73
NK3 blocking depresses windup of spinal neurons.
Species:  Rat
Tissue:  Neonatal rat spinal.
References:  4
Modulation of thermal hyperalgesia in induced monoarthritic rats.
Species:  Rat
Tissue:  In vivo.
References:  108
Activation of central tachykinin NK3 receptors inhibits colonic propolsion.
Species:  Rat
Tissue:  In vivo.
References:  10
Modulation of mean arterial pressure, heart rate and motor behaviour (face washing, sniffing, wet dog shakes).
Species:  Rat
Tissue:  In vivo.
References:  13,100
Modulation of NO-dependent vasodilatation.
Species:  Rat
Tissue:  Isolated mesenteric arteries.
References:  66
In a murine model of allergic asthma, blocking of NK3 causes caused a significant decrease in the number of neutrophils and eosinophils.
Species:  Mouse
Tissue:  In vivo.
References:  71
Modulation of gamma-aminobutyric acid (GABA) release.
Species:  Mouse
Tissue:  Striatal brain slices.
References:  77
Modulation of experimental anxiety.
Species:  Mouse
Tissue:  In vivo.
References:  78
NK3 blocking decreases the amplitude and square of stimulated compound action potentials.
Species:  Rat
Tissue:  Caudal mesenteric ganglion.
References:  74
Inhibition of nociception associated with intestinal distension.
Species:  Rat
Tissue:  Intestine.
References:  31
Modulation of colonic distention-induced reflex rhythmic contractions; activation of NO-dependent and NO-independent inhibitory neurotransmission.
Species:  Rat
Tissue:  Colon.
References:  57
Regulation of giant contraction in isolated colon.
Species:  Rat
Tissue:  Isolated colon.
References:  41
Modulation of behavioural responses to noxious colo-rectal distension.
Species:  Rat
Tissue:  In vivo.
References:  38,53,80,86
Rectal distension-induced colonic net water hypersecretion is blocked by NK3 antagonists when injected intracerebroventricularly.
Species:  Rat
Tissue:  In vivo.
References:  30
Intracerebroventricular injection of NK3 receptor agonists inhibits alcohol intake in genetically selected alcohol-preferring rats.
Species:  Rat
Tissue:  In vivo.
References:  17-19
Analgesic effects are induced by NK3 receptor agonists administered to either the ventral tegmental area or nucleus accumbens septi.
Species:  Rat
Tissue:  In vivo.
References:  1
Activation of NK3 receptors in the hypothalamic paraventricular nucleus elicits antidiuretic actions.
Species:  Rat
Tissue:  In vivo.
References:  25,79
Modulation of pressor response.
Species:  Rat
Tissue:  In vivo.
References:  68,100
Modulation of vacoconstriction.
Species:  Rat
Tissue:  Arterial and venous mesenteric beds.
References:  20
Modulation of gastric secretion.
Species:  Rat
Tissue:  In vivo.
References:  50
Behavioural manifestations of 5-hydroxytryptaminergic stimulation (including head twitches, forepaw treading, flat body posture, hindlimb splaying and Straub tail).
Species:  Mouse
Tissue:  In vivo.
References:  94
Activation stimulatess yawning, chewing mouth movements and sexual arousal.
Species:  Rat
Tissue:  In vivo.
References:  93
Control of presynaptic dopamine release.
Species:  Rat
Tissue:  In vivo.
References:  40,104
Stimulation of oral movements.
Species:  Rat
Tissue:  In vivo.
References:  60
Induction of grooming.
Species:  Rat
Tissue:  In vivo.
References:  92
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Tacr3tm1Jasi Tacr3tm1Jasi/Tacr3tm1Jasi
involves: 129P2/OlaHsd * C57BL/6
MGI:892968  MP:0002798 abnormal active avoidance behavior PMID: 17558564 
Tacr3tm1Jasi Tacr3tm1Jasi/Tacr3tm1Jasi
involves: 129P2/OlaHsd * C57BL/6
MGI:892968  MP:0001463 abnormal spatial learning PMID: 17558564 
Tacr3tm1Jasi Tacr3tm1Jasi/Tacr3tm1Jasi
involves: 129P2/OlaHsd * C57BL/6
MGI:892968  MP:0004000 impaired passive avoidance behavior PMID: 17558564 
Tacr3tm1Jasi Tacr3tm1Jasi/Tacr3tm1Jasi
involves: 129P2/OlaHsd * C57BL/6
MGI:892968  MP:0001260 increased body weight PMID: 17558564 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Hypogonadotropic hypogonadism 11 with or without anosmia; HH11
Synonyms: Kallmann syndrome [Orphanet: ORPHA478] [Disease Ontology: DOID:3614]
Normosmic congenital hypogonadotropic hypogonadism [Orphanet: ORPHA432]
Disease Ontology: DOID:3614
OMIM: 614840
Orphanet: ORPHA432, ORPHA478

References

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1. Altier N, Stewart J. (1997) Tachykinin NK-1 and NK-3 selective agonists induce analgesia in the formalin test for tonic pain following intra-VTA or intra-accumbens microinfusions. Behav Brain Res89: 151-165. [PMID:9475623]

2. Anthes JC, Chapman RW, Richard C, Eckel S, Corboz M, Hey JA, Fernandez X, Greenfeder S, McLeod R, Sehring S, Rizzo C, Crawley Y, Shih NY, Piwinski J, Reichard G, Ting P, Carruthers N, Cuss FM, Billah M, Kreutner W, Egan RW. (2002) SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist. Eur J Pharmacol450: 191-202. [PMID:12206858]

3. AstraZeneca. AZD2624. Accessed on 11/09/2014. Modified on 11/09/2014. astrazeneca.com, http://openinnovation.astrazeneca.com/what-we-offer/compound/azd2624/

4. Barbieri M, Nistri A. (2001) Depression of windup of spinal neurons in the neonatal rat spinal cord in vitro by an NK3 tachykinin receptor antagonist. J Neurophysiol85: 1502-1511. [PMID:11287474]

5. Barr AJ, Watson SP, Bernal AL, Nimmo AJ. (1991) The presence of NK3 tachykinin receptors on rat uterus. Eur J Pharmacol203: 287-290. [PMID:1724757]

6. Beaujouan JC, Saffroy M, Torrens Y, Glowinski J. (1997) Potency and selectivity of the tachykinin NK3 receptor antagonist SR 142801. Eur J Pharmacol319: 307-316. [PMID:9042606]

7. Bennacef I, Tymciu S, Dhilly M, Lasne MC, Debruyne D, Perrio C, Barré L. (2004) Synthesis and biological evaluation of novel fluoro and iodo quinoline carboxamides as potential ligands of NK-3 receptors for in vivo imaging studies. Bioorg Med Chem12: 4533-4541. [PMID:15265501]

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Steven D. Douglas, Susan E. Leeman, Jeffrey Barrett, Erin Dombrowsky, Christa Y. Heyward, Pranela Remeshwar.
Tachykinin receptors: NK3 receptor. Last modified on 14/07/2015. Accessed on 28/05/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=362.