YM 218 [Ligand Id: 2204] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3307200 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559] | ||||||||
| ChEMBL | Displacement of [3H]-oxytocin from OTR receptor in human USMC cell membranes | B | 7.15 | pKi | 71 | nM | Ki | J Med Chem (2018) 61: 8670-8692 [PMID:30199637] |
| V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] | ||||||||
| GtoPdb | - | - | 9.5 | pKi | - | - | - | Pharmacol Res (2005) 51: 275-81 [PMID:15661579] |
| ChEMBL | Displacement of [3H]-AVP from human V1A receptor expressed in CHO cell membranes | B | 9.52 | pKi | 0.3 | nM | Ki | J Med Chem (2018) 61: 8670-8692 [PMID:30199637] |
| V1B receptor/Vasopressin V1b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901] | ||||||||
| ChEMBL | Displacement of [3H]-AVP from human V1B receptor expressed in CHO cell membranes | B | 4.59 | pKi | 25500 | nM | Ki | J Med Chem (2018) 61: 8670-8692 [PMID:30199637] |
| GtoPdb | - | - | 4.6 | pKi | - | - | - | Pharmacol Res (2005) 51: 275-81 [PMID:15661579] |
| V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518] | ||||||||
| GtoPdb | - | - | 6.4 | pKi | - | - | - | Pharmacol Res (2005) 51: 275-81 [PMID:15661579] |
| ChEMBL | Displacement of [3H]-AVP from human V2 receptor expressed in CHO cell membranes | B | 6.42 | pKi | 381 | nM | Ki | J Med Chem (2018) 61: 8670-8692 [PMID:30199637] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
