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ChEMBL ligand: CHEMBL567175 (Naltrindole) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
ChEMBL | Antagonist activity against delta opioid receptor assessed as effect on deltorphin-2-induced calcium response in CHO cells by aequorin luminescence based calcium assay | F | 7.95 | pKd | 11.22 | nM | Kd | J Med Chem (2007) 50: 512-520 [PMID:17266203] |
ChEMBL | Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cells | B | 8.71 | pKi | 1.97 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4603-4606 [PMID:19595591] |
ChEMBL | Displacement of [3H]DADLE from delta opioid receptor (unknown origin) expressed in HEK293T cells after 1.5 hrs by radioligand binding assay | B | 9.05 | pKi | 0.9 | nM | Ki | Eur J Med Chem (2014) 85: 818-829 [PMID:25193297] |
ChEMBL | Displacement of [3H]DADLE from delta opioid receptor (unknown origin) | B | 9.05 | pKi | 0.9 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 2860-2862 [PMID:23587424] |
ChEMBL | Displacement of [125I]-IBNalA from DOR-1 expressed in CHO cells | B | 9.3 | pKi | 0.5 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4001-4004 [PMID:21621410] |
ChEMBL | Displacement of [125I]-IBNtxA from DOR-1 expressed in CHO cells | B | 9.34 | pKi | 0.46 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4001-4004 [PMID:21621410] |
ChEMBL | Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cells | B | 9.34 | pKi | 0.46 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127176-127176 [PMID:32299730] |
ChEMBL | Displacement of [3H]DPDPE from human DOR expressed in CHO cells | B | 9.34 | pKi | 0.46 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 2927-2930 [PMID:26048798] |
ChEMBL | Binding affinity determined against Opioid receptor delta 1 from human cloned receptor | B | 9.62 | pKi | 0.24 | nM | Ki | J Med Chem (2003) 46: 3853-3864 [PMID:12930147] |
ChEMBL | Displacement of [3H]DADLE from Opioid receptor delta 1 | B | 9.66 | pKi | 0.22 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2883-2885 [PMID:11597422] |
ChEMBL | Binding affinity towards recombinant human Opioid receptor delta 1 transfected in to CHO cells for the displacement of [3H]Cl-DPDPE (delta) | B | 9.7 | pKi | 0.2 | nM | Ki | J Med Chem (2002) 45: 537-540 [PMID:11784158] |
ChEMBL | Displacement of [3H]C1-DPDPE from human recombinant Opioid receptor delta 1 on CHO cell membranes. | B | 9.7 | pKi | 0.2 | nM | Ki | J Med Chem (2003) 46: 1563-1566 [PMID:12672258] |
ChEMBL | Binding affinity for human Opioid receptor delta 1 transfected into chinese hamster ovary cells by displacing [3H]CI-DPDPE radioligand | B | 9.7 | pKi | 0.2 | nM | Ki | J Med Chem (2003) 46: 3174-3177 [PMID:12825957] |
ChEMBL | Inhibition of [3H]C1-DPDPE binding to human delta opioid receptor expressed in CHO cells | B | 9.7 | pKi | 0.2 | nM | Ki | J Med Chem (2004) 47: 5069-5075 [PMID:15456250] |
ChEMBL | Displacement of [3H]Cl-DPDPE from human recombinant delta opioid receptor expressed in CHO cells | B | 9.7 | pKi | 0.2 | nM | Ki | J Med Chem (2004) 47: 6645-6648 [PMID:15588100] |
ChEMBL | Displacement of [3H]Cl-DPDPE from human recombinant delta opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting method | B | 9.7 | pKi | 0.2 | nM | Ki | Bioorg Med Chem (2014) 22: 4067-4072 [PMID:24973818] |
ChEMBL | Binding affinity of compound was determined against Opioid receptor delta 1 from a native receptor in guinea pig | B | 9.8 | pKi | 0.16 | nM | Ki | J Med Chem (2003) 46: 3853-3864 [PMID:12930147] |
ChEMBL | Displacement of [3H]Naltrindole from human recombinant delta opioid receptor expressed in HEK293 cells after 60 mins | B | 9.8 | pKi | 0.16 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082] |
ChEMBL | Binding affinity to Opioid receptor delta 1 using [3H]DPDPE as a radioligand in guinea pig | B | 9.82 | pKi | 0.15 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 939-943 [PMID:11294396] |
ChEMBL | Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation counting | B | 9.85 | pKi | 0.14 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2289-2294 [PMID:19282177] |
ChEMBL | Displacement of [3H]diprenorphine from human recombinant delta opioid receptor expressed in in CHO cells | B | 9.97 | pKi | 0.11 | nM | Ki | Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886] |
ChEMBL | [3H]-Cl-DPDPE competition binding assay using human cloned opioid receptor delta 1 | B | 10.15 | pKi | 0.07 | nM | Ki | J Med Chem (2004) 47: 281-284 [PMID:14711299] |
ChEMBL | Apparent antagonist activity determined by measuring the ability to inhibit stimulation of [35S]GTP-gamma-S, binding to opioid receptor delta 1 in guinea pig caudate membranes | F | 10.21 | pKi | 0.06 | nM | Ki | J Med Chem (2004) 47: 1400-1412 [PMID:14998329] |
ChEMBL | The ability of compound to inhibit [35S]GTP-delta-S binding in guinea pig caudate stimulated by SNC80 (Opioid receptor delta 1) antagonist | F | 10.21 | pKi | 0.06 | nM | Ki | J Med Chem (2002) 45: 5378-5383 [PMID:12431065] |
ChEMBL | Ability to inhibit GTP-gamma-S binding to Opioid receptor delta 1 of guinea pig caudate. | B | 10.21 | pKi | 0.06 | nM | Ki | J Med Chem (1999) 42: 1673-1679 [PMID:10229636] |
ChEMBL | Antagonist activity on agonist stimulated [35S]GTP-gamma-S, binding in guinea pig caudate membranes (10 uM SNC-80 as the agonist ligand for delta-receptor) | F | 10.4 | pKi | 0.04 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 529-532 [PMID:12565965] |
ChEMBL | Compound was evaluated for binding affinity at Opioid receptor delta 1 in guinea pig brain membranes | B | 10.51 | pKi | 0.03 | nM | Ki | J Med Chem (1991) 34: 1757-1762 [PMID:1648136] |
ChEMBL | The opioid receptor affinity(Ki) was evaluated by competition with [3H]-DPDPE (delta 1) on guinea pig brain membranes | B | 10.52 | pKi | 0.03 | nM | Ki | J Med Chem (1995) 38: 402-407 [PMID:7853332] |
ChEMBL | Binding affinity was measured by the displacement of [3H]- DADLE in guinea pig brain membrane of Opioid receptor delta 1 | B | 10.52 | pKi | 0.03 | nM | Ki | J Med Chem (1990) 33: 1714-1720 [PMID:2160538] |
ChEMBL | Binding affinity was measured by the displacement of [3H]- DADLE in guinea pig brain membrane of opioid receptor delta | B | 10.52 | pKi | 0.03 | nM | Ki | J Med Chem (1990) 33: 1714-1720 [PMID:2160538] |
ChEMBL | The compound was evaluated for binding affinity against Opioid receptor delta 1 in guinea pig brain membrane using [3H]- DPDPE as ligand | B | 10.52 | pKi | 0.03 | nM | Ki | J Med Chem (1992) 35: 4325-4329 [PMID:1333013] |
ChEMBL | Displacement of [3H]Naltrindole from human recombinant delta opioid receptor expressed in HEK293 cells after 60 mins | B | 9.04 | pIC50 | 0.91 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082] |
ChEMBL | Antagonist activity at human delta opioid receptor expressed in CHO cells assessed as reduction in SNC80-induced inhibition of forskolin stimulated cAMP accumulation preincubated for 15 mins followed SNC80 and forskolin addition and measured after 10 mins relative to control | F | 9.29 | pIC50 | <0.51 | nM | IC50 | ACS Med Chem Lett (2019) 10: 450-456 [PMID:30996778] |
ChEMBL | Antagonist activity against human delta opioid receptor expressed in CHO cells assessed as inhibition of SNC80-stimulated [35S]GTPgammaS binding | F | 9.41 | pIC50 | 0.39 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2289-2294 [PMID:19282177] |
ChEMBL | Inhibition of Opioid receptor delta 1 by displacing 1 nM [3H]DPDPE in guinea pig brain membrane | B | 9.49 | pIC50 | 0.32 | nM | IC50 | J Med Chem (1992) 35: 4589-4594 [PMID:1335078] |
ChEMBL | Agonistic activity towards Opioid receptor delta 1 | F | 9.96 | pEC50 | 0.11 | nM | EC50 | J Med Chem (2003) 46: 3174-3177 [PMID:12825957] |
δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300] | ||||||||
ChEMBL | Displacement of deltorphin-II from delta opioid receptor in mouse vas deferens | B | 9.2 | pKd | 0.63 | nM | Kd | J Med Chem (2005) 48: 8035-8044 [PMID:16335927] |
ChEMBL | Displacement of [3H]- diprenorphine from delta-W284E-receptor expressed in HEK 293 cells | B | 8.74 | pKi | 1.82 | nM | Ki | J Med Chem (2001) 44: 857-862 [PMID:11300867] |
ChEMBL | Binding affinity against Opioid receptor delta 1 using [3H][D-Ala2, D-Leu5]-enkephalin as radioligand | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (1997) 40: 3192-3198 [PMID:9379438] |
ChEMBL | Displacement of [3H]- diprenorphine from delta receptor expressed in HEK 293 cells | B | 9.72 | pKi | 0.19 | nM | Ki | J Med Chem (2001) 44: 857-862 [PMID:11300867] |
ChEMBL | Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain without cerebellum | B | 9.77 | pKi | 0.17 | nM | Ki | Bioorg Med Chem (2012) 20: 5810-5831 [PMID:22967810] |
ChEMBL | Displacement of [3H]NTI from delta opioid receptor in CD1 mouse brain membranes | B | 9.82 | pKi | 0.15 | nM | Ki | J Med Chem (2007) 50: 2144-2156 [PMID:17402725] |
ChEMBL | Binding affinity against Opioid receptor delta 1 receptor binding in ICR mouse brain membranes using the radioligand [3H]naltrindole | B | 10.4 | pKi | 0.04 | nM | Ki | J Med Chem (1997) 40: 1977-1981 [PMID:9207938] |
ChEMBL | Antagonist activity at mouse delta opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of DPDPE-induced [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis | F | 9.14 | pIC50 | 0.72 | nM | IC50 | J Med Chem (2016) 59: 8381-8397 [PMID:27556704] |
ChEMBL | Antagonist activity against Opioid receptor delta 1 in mouse vas deferens assay | F | 9.2 | pA2 | 9.2 | nM | pA2 | J Med Chem (1997) 40: 3100-3108 [PMID:9301674] |
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] | ||||||||
GtoPdb | - | - | 10.43 | pKd | 0.04 | nM | Kd | Life Sci (1992) 50: PL119-24 [PMID:1313133] |
ChEMBL | Displacement of [3H]DADLE from morphine-sensitive Opioid receptor delta 1 (presence of 300 nM DELT-II) of rat brain membranes | B | 7.91 | pKi | 12.3 | nM | Ki | J Med Chem (1998) 41: 2872-2881 [PMID:9667975] |
ChEMBL | Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membrane | B | 8.8 | pKi | 1.6 | nM | Ki | J Med Chem (2004) 47: 1400-1412 [PMID:14998329] |
ChEMBL | Displacement of [3H]DPDPE from DOR in rat brain membranes incubated for 45 mins by liquid scintillation counting | B | 8.95 | pKi | 1.13 | nM | Ki | Eur J Med Chem (2019) 168: 189-198 [PMID:30822708] |
ChEMBL | Displacement of [3H]DPDPE from DOR in rat brain membranes incubated for 45 mins by liquid scintillation counting | B | 9.08 | pKi | 0.83 | nM | Ki | ACS Med Chem Lett (2020) 11: 678-685 [PMID:32435370] |
ChEMBL | Binding affinity at delta opioid receptor 1 in rat brain membrane by [3H]DADLE displacement. | B | 9.09 | pKi | 0.81 | nM | Ki | J Med Chem (2002) 45: 5378-5383 [PMID:12431065] |
ChEMBL | Binding affinity for Opioid receptor delta 1 was determined by inhibition of binding of [3H]DADLE (1.3-2.0 nM) to rat brain membranes | B | 9.39 | pKi | 0.41 | nM | Ki | J Med Chem (1999) 42: 3527-3538 [PMID:10479286] |
ChEMBL | Binding affinity to delta opioid receptor was measured using [3H]DADLE | B | 9.39 | pKi | 0.41 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 529-532 [PMID:12565965] |
ChEMBL | Compound was evaluated for the binding affinity towards Opioid receptor delta 1 in rat brain homogenates using [3H]naltrindole as radioligand | B | 9.48 | pKi | 0.33 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 151-156 |
ChEMBL | Displacement of [3H]DADLE from Opioid receptor delta 1 of rat brain membranes (DAMGO quenching mu receptor) | B | 9.54 | pKi | 0.29 | nM | Ki | J Med Chem (1998) 41: 2872-2881 [PMID:9667975] |
ChEMBL | Displacement of [3H]DADLE from delta opioid receptor in rat cerebellum membrane | B | 9.54 | pKi | 0.29 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480] |
ChEMBL | Displacement of [3H]DADLE from delta opioid receptor in rat cerebrum membranes | B | 9.54 | pKi | 0.29 | nM | Ki | Bioorg Med Chem (2012) 20: 949-961 [PMID:22197670] |
ChEMBL | Displacement of [3H]DADLE from morphine-insensitive Opioid receptor delta 1 (presence of 50 nM morphine) of rat brain membranes | B | 9.62 | pKi | 0.24 | nM | Ki | J Med Chem (1998) 41: 2872-2881 [PMID:9667975] |
ChEMBL | Binding affinity to delta opioid receptor in rat brain membrane | B | 9.66 | pKi | 0.22 | nM | Ki | Eur J Med Chem (2008) 43: 2307-2315 [PMID:18403056] |
ChEMBL | Ability to displace [3H]DADL from delta opioid receptor | B | 9.66 | pKi | 0.22 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3435-3438 [PMID:10617086] |
ChEMBL | Ability to displace [3H]DADLE radioligand from Opioid receptor delta 1 | B | 9.66 | pKi | 0.22 | nM | Ki | J Med Chem (1999) 42: 1673-1679 [PMID:10229636] |
ChEMBL | Binding affinity against Opioid receptor delta 1 from rat brain membranes using [3H]DADLE | B | 9.66 | pKi | 0.22 | nM | Ki | J Med Chem (2005) 48: 1620-1629 [PMID:15743203] |
ChEMBL | Compound was tested for its ability to displace [3H]DADLE from delta receptor in rat brain. | B | 9.66 | pKi | 0.22 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 799-804 [PMID:9871544] |
ChEMBL | Displacement of [3H]p-Cl-DPDPE from rat delta opioid receptor expressed in rat C6 cells | B | 9.7 | pKi | 0.2 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4603-4606 [PMID:19595591] |
ChEMBL | Tested for binding affinity against delta opioid receptor by displacing [3H]- DSLET radioligand from rat brain membrane preparations | B | 9.74 | pKi | 0.18 | nM | Ki | J Med Chem (1993) 36: 3182-3187 [PMID:8230106] |
ChEMBL | Compound was evaluated for the binding affinity towards Opioid receptor delta 1 in rat brain homogenates using [3H]DIDI as radioligand | B | 10.05 | pKi | 0.09 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 151-156 |
ChEMBL | Ability to inhibit binding of SNC80 to delta opioid receptor | B | 10.21 | pKi | 0.06 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3435-3438 [PMID:10617086] |
ChEMBL | Compound was evaluated for its ability to displace [3H]p-CI-DPDPE in C6 glioma cells expressing the cloned Opioid receptor delta 1 | B | 10.4 | pKi | 0.04 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 2449-2451 [PMID:11078198] |
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
ChEMBL | Displacement of [3H]U50488 from human kappa opioid receptor expressed in CHO cells | B | 7.12 | pKi | 75 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4603-4606 [PMID:19595591] |
ChEMBL | Displacement of [3H]U-69593 from Opioid receptor kappa 1 | B | 7.52 | pKi | 30 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2883-2885 [PMID:11597422] |
ChEMBL | Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells | B | 7.83 | pKi | 14.7 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127176-127176 [PMID:32299730] |
ChEMBL | Displacement of [3H]U-69,593 from human KOR expressed in CHO cells | B | 7.83 | pKi | 14.7 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 2927-2930 [PMID:26048798] |
ChEMBL | Inhibition of [3H]U-69593 binding to human kappa opioid receptor expressed in CHO cells | B | 8 | pKi | 10.1 | nM | Ki | J Med Chem (2004) 47: 5069-5075 [PMID:15456250] |
ChEMBL | Displacement of [3H]U69593 from human recombinant kappa opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting method | B | 8 | pKi | 10.1 | nM | Ki | Bioorg Med Chem (2014) 22: 4067-4072 [PMID:24973818] |
ChEMBL | Displacement of [3H]U-69593 from human recombinant kappa opioid receptor expressed in CHO cells | B | 8 | pKi | 10.1 | nM | Ki | J Med Chem (2004) 47: 6645-6648 [PMID:15588100] |
ChEMBL | Displacement of [3H]U-69593 from human recombinant Opioid receptor kappa 1 on CHO cell membranes. | B | 8 | pKi | 10.1 | nM | Ki | J Med Chem (2003) 46: 1563-1566 [PMID:12672258] |
ChEMBL | Binding affinity in recombinant human Opioid receptor kappa 1 transfected into chinese hamster ovary cells by displacing [3H]U-69593 radioligand | B | 8 | pKi | 10.1 | nM | Ki | J Med Chem (2003) 46: 3174-3177 [PMID:12825957] |
ChEMBL | Binding affinity towards recombinant human Opioid receptor kappa 1 transfected in to CHO cells for the displacement of [3H]U-69593 | B | 8 | pKi | 10.1 | nM | Ki | J Med Chem (2002) 45: 537-540 [PMID:11784158] |
ChEMBL | Binding affinity against opioid receptor kappa 1 from human cloned receptor | B | 8.36 | pKi | 4.4 | nM | Ki | J Med Chem (2003) 46: 3853-3864 [PMID:12930147] |
ChEMBL | Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting | B | 8.54 | pKi | 2.9 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2289-2294 [PMID:19282177] |
ChEMBL | Agonistic activity towards Opioid receptor kappa 1 | F | 8.31 | pEC50 | 4.95 | nM | EC50 | J Med Chem (2003) 46: 3174-3177 [PMID:12825957] |
κ receptor/Kappa opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534] | ||||||||
ChEMBL | Binding affinity against Opioid receptor kappa 1 binding in ICR mouse brain membranes using the radioligand [3H]U-69593 | B | 6.45 | pKi | 355 | nM | Ki | J Med Chem (1997) 40: 1977-1981 [PMID:9207938] |
ChEMBL | Binding affinity against Opioid receptor kappa 1 using [3H]-U-69,593 as radioligand | B | 8.02 | pKi | 9.5 | nM | Ki | J Med Chem (1997) 40: 3192-3198 [PMID:9379438] |
κ receptor/Kappa opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975] | ||||||||
ChEMBL | Displacement of [3H]diprenorphine from k-E297A-receptor expressed in HEK 293 cells | B | 7.38 | pKi | 42 | nM | Ki | J Med Chem (2001) 44: 857-862 [PMID:11300867] |
ChEMBL | Binding affinity to kappa opioid receptor in rat brain membrane | B | 7.52 | pKi | 30 | nM | Ki | Eur J Med Chem (2008) 43: 2307-2315 [PMID:18403056] |
ChEMBL | Displacement of [3H]diprenorphine from opioid receptor kappa 1 expressed in HEK 293 cells | B | 7.59 | pKi | 25.5 | nM | Ki | J Med Chem (2001) 44: 857-862 [PMID:11300867] |
ChEMBL | Compound was evaluated for the binding affinity towards Opioid receptor kappa 1 in rat brain homogenates using [3H]CI977 as radioligand | B | 7.85 | pKi | 14 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 151-156 |
ChEMBL | Compound was evaluated for its ability to displace [3H]U-69593 in CHO cells expressing the cloned Opioid receptor kappa 1 | B | 8.24 | pKi | 5.8 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 2449-2451 [PMID:11078198] |
ChEMBL | Displacement of [3H]diprenorphine from k-Y312A-receptor expressed in HEK 293 cells | B | 8.91 | pKi | 1.23 | nM | Ki | J Med Chem (2001) 44: 857-862 [PMID:11300867] |
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144] | ||||||||
ChEMBL | Compound was evaluated for binding affinity of Opioid receptor kappa 1 in guinea pig brain membranes | B | 6.48 | pKi | 332 | nM | Ki | J Med Chem (1991) 34: 1757-1762 [PMID:1648136] |
ChEMBL | Binding affinity was measured by the displacement of [3H]- EK in guinea pig brain membrane of opioid receptor kappa | B | 6.48 | pKi | 332 | nM | Ki | J Med Chem (1990) 33: 1714-1720 [PMID:2160538] |
ChEMBL | Binding affinity was measured by the displacement of [3H]- EK in guinea pig brain membrane of Opioid receptor kappa 1 | B | 6.48 | pKi | 332 | nM | Ki | J Med Chem (1990) 33: 1714-1720 [PMID:2160538] |
ChEMBL | The opioid receptor affinity(Ki) was evaluated by competition with 9 (Opioid receptor kappa 1) on guinea pig brain membranes | B | 6.48 | pKi | 332 | nM | Ki | J Med Chem (1995) 38: 402-407 [PMID:7853332] |
ChEMBL | The compound was evaluated for binding affinity against the opioid receptor kappa in guinea pig brain membranes using [3H]- U-69,593 | B | 6.48 | pKi | 332 | nM | Ki | J Med Chem (1992) 35: 4325-4329 [PMID:1333013] |
ChEMBL | Binding affinity against kappa-opioid receptor in guinea pig brain membranes | B | 6.48 | pKi | 332 | nM | Ki | J Med Chem (1994) 37: 1886-1888 [PMID:8021929] |
ChEMBL | Binding affinity at Opioid receptor kappa 1 by displacement of [3H]U-69593 in guinea pig brain membranes | B | 7.12 | pKi | 75 | nM | Ki | J Med Chem (2004) 47: 1400-1412 [PMID:14998329] |
ChEMBL | Binding affinity for Opioid receptor kappa 1 was determined by inhibition of binding of [3H]U-69593 (1.2-2.2 nM) to guinea pig brain membranes | B | 7.45 | pKi | 35.8 | nM | Ki | J Med Chem (1999) 42: 3527-3538 [PMID:10479286] |
ChEMBL | Binding affinity for kappa opioid receptor was measured using [3H]U-69593 | B | 7.45 | pKi | 35.8 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 529-532 [PMID:12565965] |
ChEMBL | Displacement of [3H]U-69593 from Opioid receptor kappa 1 of guinea pig brain membranes (pretreated with BIT and FIT to block mu and delta sites) | B | 7.47 | pKi | 34.1 | nM | Ki | J Med Chem (1998) 41: 2872-2881 [PMID:9667975] |
ChEMBL | Binding affinity to guinea pig kappa opioid receptor | B | 7.52 | pKi | 30.4 | nM | Ki | J Med Chem (2008) 51: 4404-4411 [PMID:18637671] |
ChEMBL | Ability to displace [3H]U-69593 from kappa opioid receptor | B | 7.52 | pKi | 30.4 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3435-3438 [PMID:10617086] |
ChEMBL | Compound was tested for its ability to displace [3H]U-69593 from kappa receptor in guinea pig brain. | B | 7.52 | pKi | 30.4 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 799-804 [PMID:9871544] |
ChEMBL | Ability to displace [3H]U-69593 radioligand from Opioid receptor kappa 1 | B | 7.52 | pKi | 30.4 | nM | Ki | J Med Chem (1999) 42: 1673-1679 [PMID:10229636] |
ChEMBL | Binding affinity against Opioid receptor kappa 1 from guinea pig brain membranes using [3H]U-69593 | B | 7.57 | pKi | 26.92 | nM | Ki | J Med Chem (2005) 48: 1620-1629 [PMID:15743203] |
ChEMBL | Displacement of [125I]OXY from Opioid receptor kappa 2b of guinea pig brain membranes (pretreated with BIT(mu) and FIT(delta) and in the presence of (-)U50,488) | B | 7.7 | pKi | 19.9 | nM | Ki | J Med Chem (1998) 41: 2872-2881 [PMID:9667975] |
ChEMBL | Binding affinity at kappa opioid receptor 1 in guinea pig brain by [3H]U-69593 displacement. | B | 7.8 | pKi | 15.8 | nM | Ki | J Med Chem (2002) 45: 5378-5383 [PMID:12431065] |
ChEMBL | Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membranes | B | 7.83 | pKi | 14.9 | nM | Ki | J Med Chem (2007) 50: 2144-2156 [PMID:17402725] |
ChEMBL | Binding affinity to Opioid receptor kappa 1 by using [3H]U-69593 as a radioligand from guinea pig | B | 7.84 | pKi | 14.3 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 939-943 [PMID:11294396] |
ChEMBL | Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig cerebellum | B | 7.85 | pKi | 14.01 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480] |
ChEMBL | Tested for binding activity against kappa opioid receptor using [3H]U-69593 ligand | B | 7.85 | pKi | 14 | nM | Ki | J Med Chem (1994) 37: 579-585 [PMID:8126697] |
ChEMBL | Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig cerebrum membranes | B | 7.85 | pKi | 14 | nM | Ki | Bioorg Med Chem (2012) 20: 949-961 [PMID:22197670] |
ChEMBL | Binding affinity determined against Opioid receptor kappa 1 from a native receptor in guinea pig | B | 7.99 | pKi | 10.2 | nM | Ki | J Med Chem (2003) 46: 3853-3864 [PMID:12930147] |
ChEMBL | Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig cerebellum | B | 8.04 | pKi | 9.04 | nM | Ki | Bioorg Med Chem (2012) 20: 5810-5831 [PMID:22967810] |
ChEMBL | The ability of compound to inhibit [35S]GTP-delta-S binding in guinea pig caudate stimulated by U69,593 (Opioid receptor kappa 1) antagonist | F | 8.05 | pKi | 8.9 | nM | Ki | J Med Chem (2002) 45: 5378-5383 [PMID:12431065] |
ChEMBL | Ability to inhibit GTP-gamma-S binding to Opioid receptor kappa 1 of guinea pig caudate. | B | 8.05 | pKi | 8.85 | nM | Ki | J Med Chem (1999) 42: 1673-1679 [PMID:10229636] |
ChEMBL | Ability to inhibit binding of U-69,593 to kappa opioid receptor | B | 8.05 | pKi | 8.85 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3435-3438 [PMID:10617086] |
ChEMBL | Apparent binding affinity of compound was determined by antagonism towards Opioid receptor kappa 1 in [35S]GTP-gamma-S, binding assay in guinea pig caudate | F | 8.06 | pKi | 8.8 | nM | Ki | J Med Chem (2004) 47: 1400-1412 [PMID:14998329] |
ChEMBL | Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membrane | B | 8.13 | pKi | 7.44 | nM | Ki | J Med Chem (2008) 51: 4404-4411 [PMID:18637671] |
ChEMBL | Antagonist activity on agonist stimulated [35S]GTP-gamma-S, binding in guinea pig caudate membranes (10 uM U69,593 as the agonist ligand for kappa-receptor) | F | 8.22 | pKi | 6 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 529-532 [PMID:12565965] |
ChEMBL | Antagonist activity against kappa-opioid receptor in guinea pig ileum in the presence of ethylketazocine | F | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (1994) 37: 1886-1888 [PMID:8021929] |
ChEMBL | Inhibition of opioid receptor kappa by displacing 0.5 nM [3H]bremazocine in guinea pig brain membrane | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (1992) 35: 4589-4594 [PMID:1335078] |
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
ChEMBL | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells | B | 6.82 | pKi | 151 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4603-4606 [PMID:19595591] |
ChEMBL | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells | B | 7.51 | pKi | 30.7 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127176-127176 [PMID:32299730] |
ChEMBL | Displacement of [3H]DAMGO from human MOR expressed in CHO cells | B | 7.51 | pKi | 30.7 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 2927-2930 [PMID:26048798] |
ChEMBL | Displacement of [3H]DAMGO from Opioid receptor mu 1 | B | 7.57 | pKi | 27 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2883-2885 [PMID:11597422] |
ChEMBL | Tested for binding activity against mu opioid receptor using [3H]DAMGO ligand | B | 7.84 | pKi | 14.4 | nM | Ki | J Med Chem (1994) 37: 579-585 [PMID:8126697] |
ChEMBL | Binding affinity determined against Opioid receptor mu 1 from human cloned receptor | B | 8.14 | pKi | 7.2 | nM | Ki | J Med Chem (2003) 46: 3853-3864 [PMID:12930147] |
ChEMBL | Inhibition of [3H]DAMGO binding to human Mu opioid receptor expressed in CHO cells | B | 8.2 | pKi | 6.3 | nM | Ki | J Med Chem (2004) 47: 5069-5075 [PMID:15456250] |
ChEMBL | Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cells | B | 8.2 | pKi | 6.3 | nM | Ki | J Med Chem (2004) 47: 6645-6648 [PMID:15588100] |
ChEMBL | Binding affinity towards recombinant human Opioid receptor mu 1 transfected in to CHO cells for the displacement of [3H]DAMGO (mu) | B | 8.2 | pKi | 6.3 | nM | Ki | J Med Chem (2002) 45: 537-540 [PMID:11784158] |
ChEMBL | Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cell membranes after 60 mins by scintillation counting method | B | 8.2 | pKi | 6.3 | nM | Ki | Bioorg Med Chem (2014) 22: 4067-4072 [PMID:24973818] |
ChEMBL | Displacement of [3H]DAMGO from human recombinant Opioid receptor mu 1 on CHO cell membranes. | B | 8.2 | pKi | 6.3 | nM | Ki | J Med Chem (2003) 46: 1563-1566 [PMID:12672258] |
ChEMBL | Binding affinity for human Opioid receptor mu 1 transfected into chinese hamster ovary cells by displacing [3H]DAMGO radioligand | B | 8.2 | pKi | 6.3 | nM | Ki | J Med Chem (2003) 46: 3174-3177 [PMID:12825957] |
ChEMBL | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting | B | 8.28 | pKi | 5.3 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2289-2294 [PMID:19282177] |
ChEMBL | Effective concentration agonistic activity towards Opioid receptor mu 1 | F | 8.37 | pEC50 | 4.26 | nM | EC50 | J Med Chem (2003) 46: 3174-3177 [PMID:12825957] |
μ receptor/Mu opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866] | ||||||||
ChEMBL | Binding affinity against Opioid receptor mu 1 using [3H][D-Ala2, MePhe4, Gly-ol5]-enkephalin as radioligand | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (1997) 40: 3192-3198 [PMID:9379438] |
ChEMBL | Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain without cerebellum | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2012) 20: 5810-5831 [PMID:22967810] |
ChEMBL | Binding affinity against Opioid receptor mu 1 binding in ICR mouse brain membranes using the radioligand [3H][Ala2,Glyol5]enkephalin | B | 8.21 | pKi | 6.1 | nM | Ki | J Med Chem (1997) 40: 1977-1981 [PMID:9207938] |
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] | ||||||||
ChEMBL | Binding affinity at Opioid receptor mu 1 by displacement of [3H]DAMGO in rat brain membrane | B | 6.82 | pKi | 151 | nM | Ki | J Med Chem (2004) 47: 1400-1412 [PMID:14998329] |
ChEMBL | Binding affinity for Opioid receptor mu 1 was determined by inhibition of binding of [3H]DAMGO (1.4-3 nM) to rat brain membranes | B | 7 | pKi | 99 | nM | Ki | J Med Chem (1999) 42: 3527-3538 [PMID:10479286] |
ChEMBL | Binding affinity to mu opioid receptor was measured using [3H]DAMGO | B | 7 | pKi | 99 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 529-532 [PMID:12565965] |
ChEMBL | Displacement of [3H]DAMGO from Opioid receptor mu 1 of rat brain membranes | B | 7.3 | pKi | 50 | nM | Ki | J Med Chem (1998) 41: 2872-2881 [PMID:9667975] |
ChEMBL | Displacement of [3H]- diprenorphine from mu-receptor expressed in HEK 293 cells | B | 7.46 | pKi | 34.4 | nM | Ki | J Med Chem (2001) 44: 857-862 [PMID:11300867] |
ChEMBL | Compound was evaluated for the binding affinity towards mu opioid receptor in rat brain homogenates using [3H]DAMGO as radioligand | B | 7.52 | pKi | 30.4 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 151-156 |
ChEMBL | Ability to displace [3H]DAMGO from mu opioid receptor | B | 7.57 | pKi | 27 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3435-3438 [PMID:10617086] |
ChEMBL | Compound was tested for its ability to displace [3H]DAMGO from mu receptor in rat brain. | B | 7.57 | pKi | 27 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 799-804 [PMID:9871544] |
ChEMBL | Ability to displace [3H]DAMGO radioligand from Opioid receptor mu 1 | B | 7.57 | pKi | 27 | nM | Ki | J Med Chem (1999) 42: 1673-1679 [PMID:10229636] |
ChEMBL | Binding affinity to mu opioid receptor in rat brain membrane | B | 7.57 | pKi | 27 | nM | Ki | Eur J Med Chem (2008) 43: 2307-2315 [PMID:18403056] |
ChEMBL | Binding affinity against Opioid receptor mu 1 from rat brain membranes using [3H]DAMGO | B | 7.57 | pKi | 26.92 | nM | Ki | J Med Chem (2005) 48: 1620-1629 [PMID:15743203] |
ChEMBL | Displacement of [3H]DAMGO from mu opioid receptor in rat cerebellum membrane | B | 7.63 | pKi | 23.64 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480] |
ChEMBL | Displacement of [3H]DAMGO from mu opioid receptor in rat cerebrum membranes | B | 7.63 | pKi | 23.6 | nM | Ki | Bioorg Med Chem (2012) 20: 949-961 [PMID:22197670] |
ChEMBL | Displacement of [3H]- diprenorphine from mu-K303E-receptor expressed in HEK 293 | B | 7.87 | pKi | 13.5 | nM | Ki | J Med Chem (2001) 44: 857-862 [PMID:11300867] |
ChEMBL | Binding affinity at mu opioid receptor 1 in rat brain membrane by [3H]DAMGO displacement. | B | 7.89 | pKi | 13 | nM | Ki | J Med Chem (2002) 45: 5378-5383 [PMID:12431065] |
ChEMBL | Tested for binding affinity against mu opioid receptor fby displacing [3H]- DAMGO radioligand from rat brain membrane preparations | B | 8.41 | pKi | 3.86 | nM | Ki | J Med Chem (1993) 36: 3182-3187 [PMID:8230106] |
ChEMBL | Compound was evaluated for its ability to displace [3H]DAMGO in C6 glioma cells expressing the cloned Opioid receptor mu 1 | B | 8.43 | pKi | 3.7 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 2449-2451 [PMID:11078198] |
ChEMBL | Ability to inhibit binding of [3H]DAMGO to mu opioid receptor | B | 8.49 | pKi | 3.2 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3435-3438 [PMID:10617086] |
ChEMBL | Displacement of [3H]- diprenorphine from mu-W318A-receptor expressed in HEK 293 | B | 9.44 | pKi | 0.36 | nM | Ki | J Med Chem (2001) 44: 857-862 [PMID:11300867] |
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266] | ||||||||
ChEMBL | Displacement of endomorphin-2 from mu opioid receptor in guinea pig ileum | B | 7.3 | pKd | 50.12 | nM | Kd | J Med Chem (2005) 48: 8035-8044 [PMID:16335927] |
ChEMBL | Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membranes | B | 7.47 | pKi | 33.9 | nM | Ki | J Med Chem (2007) 50: 2144-2156 [PMID:17402725] |
ChEMBL | Binding affinity to Opioid receptor mu 1 by using [3H]DAMGO as a radioligand from guinea pig | B | 7.56 | pKi | 27.5 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 939-943 [PMID:11294396] |
ChEMBL | Binding affinity to guinea pig mu opioid receptor | B | 7.57 | pKi | 27 | nM | Ki | J Med Chem (2008) 51: 4404-4411 [PMID:18637671] |
ChEMBL | Binding affinity of compound was determined against Opioid receptor mu 1 from native receptor in guinea pig | B | 7.83 | pKi | 14.7 | nM | Ki | J Med Chem (2003) 46: 3853-3864 [PMID:12930147] |
ChEMBL | Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membrane | B | 7.9 | pKi | 12.7 | nM | Ki | J Med Chem (2008) 51: 4404-4411 [PMID:18637671] |
ChEMBL | Binding affinity was measured by the displacement of [3H]- DAMGO in guinea pig brain membrane of Opioid receptor mu 1 | B | 8.42 | pKi | 3.8 | nM | Ki | J Med Chem (1990) 33: 1714-1720 [PMID:2160538] |
ChEMBL | Binding affinity was measured by the displacement of [3H]- DAMGO in guinea pig brain membrane of Opioid receptor mu 1 | B | 8.42 | pKi | 3.8 | nM | Ki | J Med Chem (1990) 33: 1714-1720 [PMID:2160538] |
ChEMBL | The opioid receptor affinity(Ki) was evaluated by competition with [3H]DAMGO (mu) on guinea pig brain membranes | B | 8.42 | pKi | 3.8 | nM | Ki | J Med Chem (1995) 38: 402-407 [PMID:7853332] |
ChEMBL | The compound was evaluated for binding affinity against opioid receptor mu in guinea pig brain membranes using [3H]- DAMGO as ligand | B | 8.42 | pKi | 3.8 | nM | Ki | J Med Chem (1992) 35: 4325-4329 [PMID:1333013] |
ChEMBL | Binding affinity against mu-opioid receptor in guinea pig brain membranes | B | 8.42 | pKi | 3.8 | nM | Ki | J Med Chem (1994) 37: 1886-1888 [PMID:8021929] |
ChEMBL | Compound was evaluated for binding affinity at Opioid receptor mu 1 in guinea pig brain membranes | B | 8.42 | pKi | 3.8 | nM | Ki | J Med Chem (1991) 34: 1757-1762 [PMID:1648136] |
ChEMBL | Apparent binding affinity of compound was determined by antagonism towards Opioid receptor mu 1 in [35S]GTP-gamma-S, binding assay in guinea pig caudate | F | 8.49 | pKi | 3.2 | nM | Ki | J Med Chem (2004) 47: 1400-1412 [PMID:14998329] |
ChEMBL | The ability of compound to inhibit [35S]GTP-delta-S binding in guinea pig caudate stimulated by DAMGO (Opioid receptor mu 1) antagonist | F | 8.49 | pKi | 3.2 | nM | Ki | J Med Chem (2002) 45: 5378-5383 [PMID:12431065] |
ChEMBL | Ability to inhibit GTP-gamma-S binding to Opioid receptor mu 1 of guinea pig caudate. | B | 8.49 | pKi | 3.2 | nM | Ki | J Med Chem (1999) 42: 1673-1679 [PMID:10229636] |
ChEMBL | Antagonist activity on agonist stimulated [35S]GTP-gamma-S, binding in guinea pig caudate membranes (10 uM DAMGO as the agonist ligand for mu-receptor) | F | 8.74 | pKi | 1.8 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 529-532 [PMID:12565965] |
ChEMBL | Antagonist activity against mu-opioid receptor in guinea pig ileum in the presence of morphine | F | 4.95 | pIC50 | 11200 | nM | IC50 | J Med Chem (1994) 37: 1886-1888 [PMID:8021929] |
ChEMBL | Inhibition of opioid receptor mu by displacing 1 nM [3H]DAGO in guinea pig brain membrane | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (1992) 35: 4589-4594 [PMID:1335078] |
ChEMBL | Antagonist activity against Opioid receptor mu 1 iin a guinea pig ileum assay | F | 7.3 | pA2 | 7.3 | nM | pA2 | J Med Chem (1997) 40: 3100-3108 [PMID:9301674] |
NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] | ||||||||
ChEMBL | Binding affinity against delta-opioid receptor in guinea pig brain membranes | B | 10.52 | pKi | 0.03 | nM | Ki | J Med Chem (1994) 37: 1886-1888 [PMID:8021929] |
ChEMBL | Activity at NOP expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding | F | 8.41 | pEC50 | 3.9 | nM | EC50 | Bioorg Med Chem (2009) 17: 6671-6681 [PMID:19683449] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]