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ChEMBL ligand: CHEMBL201945 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
ChEMBL | Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2006) 49: 847-849 [PMID:16451050] |
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
ChEMBL | Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Med Chem (2006) 49: 847-849 [PMID:16451050] |
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
ChEMBL | Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells | B | 5.17 | pIC50 | 6700 | nM | IC50 | J Med Chem (2006) 49: 847-849 [PMID:16451050] |
NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] | ||||||||
ChEMBL | Displacement of [3H]N/OFQ from human recombinant NOP receptor expressed in CHO cells | B | 9.62 | pKi | 0.24 | nM | Ki | Bioorg Med Chem (2009) 17: 5080-5095 [PMID:19527931] |
GtoPdb | - | - | 9.62 | pKi | 0.24 | nM | Ki | Eur J Pharmacol (2009) 614: 50-7 [PMID:19445927] |
ChEMBL | Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells | B | 9.57 | pIC50 | 0.27 | nM | IC50 | J Med Chem (2006) 49: 847-849 [PMID:16451050] |
ChEMBL | Antagonist activity on nociceptin-induced [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells | F | 9.82 | pIC50 | 0.15 | nM | IC50 | J Med Chem (2006) 49: 847-849 [PMID:16451050] |
GtoPdb | - | - | 10 | pIC50 | 0.1 | nM | IC50 |
Eur J Pharmacol (2009) 614: 50-7 [PMID:19445927]; J Med Chem (2006) 49: 847-9 [PMID:16451050] |
ChEMBL | Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells | F | 6 | pEC50 | >1000 | nM | EC50 | J Med Chem (2006) 49: 847-849 [PMID:16451050] |
NOP receptor/Nociceptin receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621] [GtoPdb: 320] [UniProtKB: P35377] | ||||||||
ChEMBL | Antagonist activity at nociceptin receptor in Swiss mouse vas deferens assessed as inhibition of electrically evoked twitches | F | 8.24 | pKd | 5.75 | nM | Kd | Bioorg Med Chem (2009) 17: 5080-5095 [PMID:19527931] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]