clomiphene

Ligand id: 4159

Name: clomiphene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 9
Topological polar surface area 12.47
Molecular weight 405.19
XLogP 9.85
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (source: FDA (1967))
IUPAC Name
{2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]ethyl}diethylamine
International Nonproprietary Names
INN number INN
1309 clomifene
Synonyms
Androxal®
Clomid®
clomifene
MER-41
MRL-41
Omifin®
RMI-16289
Database Links
CAS Registry No. 911-45-5 (source: Scifinder)
ChEBI CHEBI:3752
ChEMBL Ligand CHEMBL2355051
DrugBank Ligand DB00882
PubChem CID 2800
Search Google for chemical match using the InChIKey GKIRPKYJQBWNGO-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GKIRPKYJQBWNGO
Search PubMed clinical trials clomifene
Search PubMed titles clomifene
Search PubMed titles/abstracts clomifene
Wikipedia Clomifene
Comments
Clomiphene is an estrogen receptor alpha modulator, it can act an agonist or antagonist depending on the target tissue. The approved drug clomiphene is a racemic mixture of the two geometric isomers, E and Z clomiphene (also known as enclomiphene and zuclomiphene). Zuclomifene is the more active isomer.