clomiphene

Ligand id: 4159

Name: clomiphene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 9
Topological polar surface area 12.47
Molecular weight 405.19
XLogP 9.85
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Clomiphene is used to treat female infertility due to diseases such as polycystic ovary syndrome, where ovulation fails due to deficient hormonal stimulation.
Mechanism Of Action and Pharmacodynamic Effects
Although te precise mechanism is not well defined (direct activation of the hypothalamic-pituitary axis, or altered estrogen-induced feed-back inhibition), the outcome of treatment with clomiphene is drug-induced release of the gonadotropins FSH and LH, resulting in the development and maturation of an ovarian follicle and subsequent ovulation.