cyclothiazide

Ligand id: 4167

Name: cyclothiazide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 135.12
Molecular weight 389.03
XLogP 0.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes
IUPAC Name
3-{bicyclo[2.2.1]hept-5-en-2-yl}-6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
International Nonproprietary Names
INN number INN
1138 cyclothiazide
Synonyms
Anhydron®
Aquirel®
Database Links
CAS Registry No. 2259-96-3 (source: SciFinder)
ChEMBL Ligand CHEMBL61593
DrugBank Ligand DB00606
PubChem CID 2910
Search Google for chemical match using the InChIKey BOCUKUHCLICSIY-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BOCUKUHCLICSIY
Search PubMed clinical trials cyclothiazide
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Search PubMed titles/abstracts cyclothiazide
Wikipedia Cyclothiazide
Comments
Cyclothiazide functions primarily as an inhibior of the sodium-chloride symporter (SLC12A3) in distal convoluted tubules.