cyclothiazide

Ligand id: 4167

Name: cyclothiazide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 135.12
Molecular weight 389.03
XLogP 0.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
We have been unable to find peer reviewed affinity data to quantify the interaction between this drug and any of its proposed human molecular targets.
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
GluA2 Hs Allosteric modulator Positive 5.7 pEC50 - 2
pEC50 5.7 (EC50 2.24x10-6 M) [2]
GluA4 Hs Allosteric modulator Positive 5.4 pEC50 - 2
pEC50 5.4 (EC50 3.91x10-6 M) [2]
GluA3 Hs Allosteric modulator Positive 4.9 pEC50 - 2
pEC50 4.9 (EC50 1.37x10-5 M) [2]
GluA1 Hs Allosteric modulator Positive 4.7 pEC50 - 2
pEC50 4.7 (EC50 1.9x10-5 M) [2]
Selectivity at transporters
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Target Sp. Type Action Affinity Units Concentration range (M) Reference
Na-Cl symporter Hs Inhibitor Inhibition - - -
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields