leflunomide

Ligand id: 6825

Name: leflunomide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 55.13
Molecular weight 270.06
XLogP 3.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1998))
Is prodrug? Yes
Active form teriflunomide
IUPAC Name
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
International Nonproprietary Names
INN number INN
5079 leflunomide
Synonyms
Arabloc® | Arava® | HWA 486 | HWA-486 | lefunamide | SU-101
Database Links
CAS Registry No. 75706-12-6
ChEMBL Ligand CHEMBL960
DrugBank Ligand DB01097
GtoPdb PubChem SID 178103431
PubChem CID 3899
Search Google for chemical match using the InChIKey VHOGYURTWQBHIL-UHFFFAOYSA-N
Search Google for chemicals with the same backbone VHOGYURTWQBHIL
Search PubMed clinical trials leflunomide
Search PubMed titles leflunomide
Search PubMed titles/abstracts leflunomide
Search UniChem for chemical match using the InChIKey VHOGYURTWQBHIL-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone VHOGYURTWQBHIL
Wikipedia Leflunomide
Comments
Inhibits dihydroorotate dehydrogenase.