cetuximab

Ligand id: 6882

Name: cetuximab

Classification
Compound class Antibody
Approved drug? Yes (FDA (2004), EMA (2004))
International Nonproprietary Names
INN number INN
7906 cetuximab
Synonyms
C225 | Erbitux® | IMC-225 | IMC-C225
Comments
Cetuximab binds to and competitively inhibits the activity of the epidermal growth factor receptor (EGFR).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Biosimilars:
As Bristol-Myers Squibb's original EU and US patents for cetuximab have expired, challengers of cetuximab's market position are developing biosimilar and/or biobetter cetuximab.
Celltrion's CT-P15 is a cetuximab biosimilar, intended for the treatment of colorectal cancer. MabTech-Sorrento's STI-001 is a proposed biobetter cetuximab (perhaps because synthesis in CHO cells creates a different glycosylation pattern to that of cetuximab which is made in mouse cells, and may be less likely to cause side-effects such as immunogenicity and hypersensitivity). STI-001 has completed Phase 3 clinical trial in China. Neither of these agents is associated with any clinical studies that are registered with ClinicalTrials.gov.
Database Links
Specialist databases
IMGT/mAb-DB 151
Other databases
GtoPdb PubChem SID 178103464
PubChem SID 178103464
Search PubMed clinical trials cetuximab
Search PubMed titles cetuximab
Search PubMed titles/abstracts cetuximab
Wikipedia Cetuximab