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metreleptin   Click here for help

GtoPdb Ligand ID: 7333

Synonyms: Myalept® | r-metHuLeptin | R-methuleptin
Approved drug
metreleptin is an approved drug (FDA (2014), EMA (2018))
Compound class: Peptide
Comment: Metreleptin is a recombinant, 147 amino acid (~16kDa), N-methionyl- analogue of human leptin [1]. Leptin is an adipokine (cytokine secreted by adipose tissue).
No information available.
Summary of Clinical Use Click here for help
First approved by the US FDA in Feb 2014, to treat leptin deficiency and its associated symptoms in patients with congenital or acquired generalized lipodystrophy.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Acts to regulate adipose-tissue mass via the leptin receptor (LEPR).
External links Click here for help
For extended ADME data see the following:

Drugs.com
European Medicines Agency (EMA)