omacetaxine mepesuccinate

Ligand id: 7454

Name: omacetaxine mepesuccinate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 123.99
Molecular weight 545.26
XLogP 2.03
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Natural product or derivative
Approved drug? Yes (source: FDA (2012))
International Nonproprietary Names
INN number INN
8885 omacetaxine mepesuccinate
Synonyms
CGX-635
HHT
homoharringtonine
Myelostat®
Synribo®
Database Links
CAS Registry No. 26833-87-4
ChEBI CHEBI:71019
ChEMBL Ligand CHEMBL46286
PubChem CID 285033
RCSB PDB Ligand HMT
Search Google for chemical match using the InChIKey HYFHYPWGAURHIV-JFIAXGOJSA-N
Search Google for chemicals with the same backbone HYFHYPWGAURHIV
Search PubMed clinical trials omacetaxine mepesuccinate
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Wikipedia Omacetaxine mepesuccinate
Comments
Omacetaxine mepesuccinate is a semi-synthetic derivative of the alkaloid cephalotaxine from Cephalotaxus harringtonia. Note that this compound is represented on Drugbank with slightly different stereochemistry by the entry DB04865.