omacetaxine mepesuccinate

Ligand id: 7454

Name: omacetaxine mepesuccinate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 123.99
Molecular weight 545.26
XLogP 2.03
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Natural product or derivative
Approved drug? Yes (FDA (2012))
International Nonproprietary Names
INN number INN
8885 omacetaxine mepesuccinate
Synonyms
CGX-635 | HHT | homoharringtonine | Myelostat® | Synribo®
Comments
Omacetaxine mepesuccinate is a semi-synthetic derivative of the alkaloid cephalotaxine from Cephalotaxus harringtonia. Note that this compound is represented on Drugbank with slightly different stereochemistry by the entry DB04865.
Database Links
CAS Registry No. 26833-87-4
ChEBI CHEBI:71019
ChEMBL Ligand CHEMBL46286
GtoPdb PubChem SID 187051757
PubChem CID 285033
RCSB PDB Ligand HMT
Search Google for chemical match using the InChIKey HYFHYPWGAURHIV-JFIAXGOJSA-N
Search Google for chemicals with the same backbone HYFHYPWGAURHIV
Search PubMed clinical trials omacetaxine mepesuccinate
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Search PubMed titles/abstracts omacetaxine mepesuccinate
Search UniChem for chemical match using the InChIKey HYFHYPWGAURHIV-JFIAXGOJSA-N
Search UniChem for chemicals with the same backbone HYFHYPWGAURHIV
Wikipedia Omacetaxine mepesuccinate

Product suppliers

Tocris
Homoharringtonine
Cat. No. 1416