omacetaxine mepesuccinate

Ligand id: 7454

Name: omacetaxine mepesuccinate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 123.99
Molecular weight 545.26
XLogP 2.03
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Cai Z, Lin M, Wuchter C, Ruppert V, Dörken B, Ludwig WD, Karawajew L. (2001)
Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation.
Leukemia, 15 (4): 567-74. [PMID:11368358]
2. Fresno M, Jiménez A, Vázquez D. (1977)
Inhibition of translation in eukaryotic systems by harringtonine.
Eur. J. Biochem., 72 (2): 323-30. [PMID:319998]
3. Tscherne JS, Pestka S. (1975)
Inhibition of protein synthesis in intact HeLa cells.
Antimicrob. Agents Chemother., 8 (4): 479-87. [PMID:1190754]
4. Zhou DC, Zittoun R, Marie JP. (1995)
Homoharringtonine: an effective new natural product in cancer chemotherapy.
Bull Cancer, 82 (12): 987-95. [PMID:8745664]