ioflupane   Click here for help

GtoPdb Ligand ID: 7653

Synonyms: 123I-FP-CIT | 123I-ioflupane | DaTSCAN®
Approved drug
ioflupane is an approved drug (EMA (2000), FDA (2011))
Compound class: Synthetic organic
Comment: This compound is represented on ChEMBL with slightly different stereochemistry by CHEMBL2096623.
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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 29.54
Molecular weight 431.08
XLogP 4.31
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES FCCCN1C2CCC1C(C(C2)c1ccc(cc1)I)C(=O)OC
Isomeric SMILES FCCCN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)c1ccc(cc1)[123I])C(=O)OC
InChI InChI=1S/C18H23FINO2/c1-23-18(22)17-15(12-3-5-13(20)6-4-12)11-14-7-8-16(17)21(14)10-2-9-19/h3-6,14-17H,2,7-11H2,1H3/t14-,15+,16+,17-/m0/s1/i20-4
InChI Key HXWLAJVUJSVENX-HFIFKADTSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA (2000), FDA (2011))
IUPAC Name Click here for help
methyl (1S,3S,4S,5R)-8-(3-fluoropropyl)-3-(4-iodanylphenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
International Nonproprietary Names Click here for help
INN number INN
7500 ioflupane (123I)
Synonyms Click here for help
123I-FP-CIT | 123I-ioflupane | DaTSCAN®
Database Links Click here for help
CAS Registry No. 155798-07-5
ChEBI CHEBI:68855
DrugCentral Ligand 4230
GtoPdb PubChem SID 223365988
PubChem CID 3086674
Search Google for chemical match using the InChIKey HXWLAJVUJSVENX-HFIFKADTSA-N
Search Google for chemicals with the same backbone HXWLAJVUJSVENX
Search PubMed clinical trials ioflupane
Search PubMed titles ioflupane
Search PubMed titles/abstracts ioflupane
UniChem Compound Search for chemical match using the InChIKey HXWLAJVUJSVENX-HFIFKADTSA-N
UniChem Connectivity Search for chemical match using the InChIKey HXWLAJVUJSVENX-HFIFKADTSA-N
Wikipedia Ioflupane (123I)