Ligand id: 7653

Name: ioflupane

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 29.54
Molecular weight 431.08
XLogP 4.86
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Ioflupane is a radiopharmaceutical drug. It is used for striatal dopamine transporter visualization using single photon emission computed tomography (SPECT) brain imaging, for the diagnosis/differential diagnosis of Parkinson's disease [1-2], and diagnosis of dementia with Lewy bodies [3].
Mechanism Of Action and Pharmacodynamic Effects
Ioflupane binds to dopamine transporters. As these are diminished in Parkinson's disease, the pattern of binding in the striatum is abnormal and is diagnostic of the disease.
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