CEP-1347

Ligand id: 8173

Name: CEP-1347

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 145.32
Molecular weight 615.19
XLogP 7.52
No. Lipinski's rules broken 1

Molecular properties generated using the CDK
Classification
Compound class Synthetic organic
Synonyms
CEP 1347 | CEP1347 | KT-7515 | KT7515 [5]
Comments
CEP-1347 is a semi-synthetic analogue of the natural alkaloid K-252a [5]. CEP-1347 was originally identified as a pan-mixed lineage kinase (MLK) family inhibitor [8]. In this setting it inhibits downstream c-jun N-terminal kinase (JNK) activation and has neuroprotective activity [1-2,7].
Database Links
ChEMBL Ligand CHEMBL290352
GtoPdb PubChem SID 249565853
PubChem CID 9917013
Search Google for chemical match using the InChIKey SCMLRESZJCKCTC-KMYQRJGFSA-N
Search Google for chemicals with the same backbone SCMLRESZJCKCTC
Search UniChem for chemical match using the InChIKey SCMLRESZJCKCTC-KMYQRJGFSA-N
Search UniChem for chemicals with the same backbone SCMLRESZJCKCTC

Product suppliers

Tocris
CEP 1347
Cat. No. 4924