CEP-1374

Ligand id: 8173

Name: CEP-1374

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 145.32
Molecular weight 615.19
XLogP 4.96
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Goodfellow VS, Loweth CJ, Ravula SB, Wiemann T, Nguyen T, Xu Y, Todd DE, Sheppard D, Pollack S, Polesskaya O et al.. (2013)
Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.
J. Med. Chem.56 (20): 8032-48. [PMID:24044867]
2. Harris CA, Deshmukh M, Tsui-Pierchala B, Maroney AC, Johnson Jr EM. (2002)
Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.
J. Neurosci.22 (1): 103-13. [PMID:11756493]
3. Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA et al.. (2001)
Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.
J. Biol. Chem.276 (27): 25302-8. [PMID:11325962]
4. Saporito MS, Brown EM, Miller MS, Carswell S. (1999)
CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.
J. Pharmacol. Exp. Ther.288 (2): 421-7. [PMID:9918541]