CEP-1347

Ligand id: 8173

Name: CEP-1347

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 145.32
Molecular weight 615.19
XLogP 4.96
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Apostol BL, Simmons DA, Zuccato C, Illes K, Pallos J, Casale M, Conforti P, Ramos C, Roarke M, Kathuria S et al.. (2008)
CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.
Mol. Cell. Neurosci., 39 (1): 8-20. [PMID:18602275]
2. Conforti P, Ramos C, Apostol BL, Simmons DA, Nguyen HP, Riess O, Thompson LM, Zuccato C, Cattaneo E. (2008)
Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347.
Mol. Cell. Neurosci., 39 (1): 1-7. [PMID:18571429]
3. Goodfellow VS, Loweth CJ, Ravula SB, Wiemann T, Nguyen T, Xu Y, Todd DE, Sheppard D, Pollack S, Polesskaya O et al.. (2013)
Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.
J. Med. Chem., 56 (20): 8032-48. [PMID:24044867]
4. Harris CA, Deshmukh M, Tsui-Pierchala B, Maroney AC, Johnson Jr EM. (2002)
Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.
J. Neurosci., 22 (1): 103-13. [PMID:11756493]
5. Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA et al.. (2001)
Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.
J. Biol. Chem., 276 (27): 25302-8. [PMID:11325962]
6. Parkinson Study Group PRECEPT Investigators. (2007)
Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease.
Neurology, 69 (15): 1480-90. [PMID:17881719]
7. Pirvola U, Xing-Qun L, Virkkala J, Saarma M, Murakata C, Camoratto AM, Walton KM, Ylikoski J. (2000)
Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation.
J. Neurosci., 20 (1): 43-50. [PMID:10627579]
8. Saporito MS, Brown EM, Miller MS, Carswell S. (1999)
CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.
J. Pharmacol. Exp. Ther., 288 (2): 421-7. [PMID:9918541]
9. Siu M, Sengupta Ghosh A, Lewcock JW. (2018)
Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration.
J. Med. Chem., [Epub ahead of print]. [PMID:29863360]