brivaracetam

Ligand id: 9041

Name: brivaracetam

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 63.4
Molecular weight 212.15
XLogP 0.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (source: FDA (2016))
IUPAC Name
(2S)-2-[(4R)-2-oxo-4-propylpyrrolidin-1-yl]butanamide
International Nonproprietary Names
INN number INN
8642 brivaracetam
Synonyms
Names References
2-(2-oxo-4-propylpyrrolidin-1-yl)butanamide
Briviact®
compound 83α 1
UCB 34714 3
UCB-34714
UCB34714
Database Links
BindingDB Ligand 50422531
CAS Registry No. 357336-20-0 (source: WHO INN record)
ChEMBL Ligand CHEMBL607400
PubChem CID 9837243
Search Google for chemical match using the InChIKey MSYKRHVOOPPJKU-BDAKNGLRSA-N
Search Google for chemicals with the same backbone MSYKRHVOOPPJKU
Search PubMed clinical trials brivaracetam
Search PubMed titles brivaracetam
Search PubMed titles/abstracts brivaracetam
Wikipedia Brivaracetam
Comments
Brivaracetam is a 4-n-propyl analogue of levetiracetam with anticonvulsant properties [3]. Like levetiracetam this drug inhibits synaptic vesicle protein 2A (SV2A), but with 10X higher binding affinity. Brivaracetam is brain penetrant and has a fast onset of action [2]. It can also inhibit sodium channels.