Ligand id: 9041

Name: brivaracetam

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 63.4
Molecular weight 212.15
XLogP 0.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Kenda BM, Matagne AC, Talaga PE, Pasau PM, Differding E, Lallemand BI, Frycia AM, Moureau FG, Klitgaard HV, Gillard MR et al.. (2004)
Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity.
J. Med. Chem., 47 (3): 530-49. [PMID:14736235]
2. Nicolas JM, Hannestad J, Holden D, Kervyn S, Nabulsi N, Tytgat D, Huang Y, Chanteux H, Staelens L, Matagne A et al.. (2016)
Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action.
Epilepsia, 57 (2): 201-9. [PMID:26663401]
3. von Rosenstiel P. (2007)
Brivaracetam (UCB 34714).
Neurotherapeutics, 4 (1): 84-7. [PMID:17199019]