BIX02189

Ligand id: 9380

Name: BIX02189

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 64.68
Molecular weight 440.22
XLogP 5.57
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(3Z)-3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide
Synonyms
BIX 02189 | BIX-02189
Comments
BIX02189 is an experimental, small molecule inhibitor of mitogen-activated protein kinase kinase 5 (MEK5; MAP2K5) [1]. It is more potent than BIX02188, described in the same article. Also inhibits ERK5 (MAPK7).
Database Links
GtoPdb PubChem SID 328083482
PubChem CID 46931012
Search Google for chemical match using the InChIKey HOMJAAIVTDVQJA-IZHYLOQSSA-N
Search Google for chemicals with the same backbone HOMJAAIVTDVQJA
Search UniChem for chemical match using the InChIKey HOMJAAIVTDVQJA-IZHYLOQSSA-N
Search UniChem for chemicals with the same backbone HOMJAAIVTDVQJA

Product suppliers

Tocris
BIX 02189
Cat. No. 4842