BIX02189

Ligand id: 9380

Name: BIX02189

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 64.68
Molecular weight 440.22
XLogP 5.57
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(3Z)-3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide
Synonyms
BIX 02189 | BIX-02189
Database Links
PubChem CID 46931012
Search Google for chemical match using the InChIKey HOMJAAIVTDVQJA-IZHYLOQSSA-N
Search Google for chemicals with the same backbone HOMJAAIVTDVQJA
Search UniChem for chemical match using the InChIKey HOMJAAIVTDVQJA-IZHYLOQSSA-N
Search UniChem for chemicals with the same backbone HOMJAAIVTDVQJA
Comments
BIX02189 is an experimental, small molecule inhibitor of mitogen-activated protein kinase kinase 5 (MEK5; MAP2K5) [1]. It is more potent than BIX02188, described in the same article. Also inhibits ERK5 (MAPK7).