Fibromun

Ligand id: 9757

Name: Fibromun

Classification
Compound class Antibody
Comments
Fibromun (L19-TNF) is a trimrtic homodimer that froms from engineered peptides for the L19 antibody in scFv format fused to human TNF [1]. LIke Darleukin, Fibromun targets the TNF to the tumour microenvironment via L19 binding to the angiogenesis-associated isoform of fibronectin (specifically the extradomain B or EDB). Fibromun is being investigated as an immuno-oncology therapeutic. It is one of a growing number of so-called 'immunocytokines' entering clinical development.
Database Links
GtoPdb PubChem SID 354702230