Synonyms: Florafur® | FT-207 | FT207 | Ftorafur®
tegafur is an approved drug (EMA (2011))
Compound class:
Synthetic organic
Comment: Like capecitabine and floxuridine, tegafur is a prodrug of the chemotherapeutic agent 5-fluorouracil. It is orally active. The INN specifies tegafur as a racemic mixture of enantiomers. We show the molecule without specified stereochemistry to represent the mixture.
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Bioactivity Comments |
We have been unable to find publicly available bioactivity data for this drug at a defined molecular target, and have therefore not tagged a primary drug target. Tegafur inhibits growth of drug-sensitive HT-29 human colon cancer cells with an IC50 of 201 μM [1]. In this same study it inhibited growth of 4T1 breast carcinoma lung metastases and growth of HT-29 tumours in a mouse xenograft |
Enzymes Catalysing Reactions with this Compound as a Substrate or Product | ||||||||
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Targets where the ligand is described in the comment field | |
Target | Comment |
dihydropyrimidine dehydrogenase | Dihydropyrimidine dehydrogenase is required for the first and rate-limiting step of pyrimidine catabolism. In addition to degrading pyrimidines, it also breaks down pyrimidine-based 5-fluorouracil, the anticancer cytostatic agent that is produced from chemotherapeutic prodrugs including capecitabine and tegafur. |