Synonyms: compound 18c [PMID: 28987604] | LW213
Compound class:
Synthetic organic
Comment: LW-213 is a derivative of the plant flavinoid wogonin [2], and like its parent it has anticancer activity [1,3-4]. Studies in human cutaneous T-cell lymphomas (CTCL) indicate that LW-213-induced apoptosis is mediated via activation of the PERK-eIF2α-ATF4-CHOP axis, and involves enhanced reactive oxygen species production and calcium-dependent endoplasmic reticulum stress. The primary molecular target of LW-213 has not been defined.
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