Synonyms: compound 18c [PMID: 28987604] | LW213
Compound class:
Synthetic organic
Comment: LW-213 is a derivative of the plant flavinoid wogonin [2], and like its parent it has anticancer activity [1,3-4]. Studies in human cutaneous T-cell lymphomas (CTCL) indicate that LW-213-induced apoptosis is mediated via activation of the PERK-eIF2α-ATF4-CHOP axis, and involves enhanced reactive oxygen species production and calcium-dependent endoplasmic reticulum stress. The primary molecular target of LW-213 has not been defined.
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References |
1. Liu X, Hu P, Li H, Yu XX, Wang XY, Qing YJ, Wang ZY, Wang HZ, Zhu MY, Guo QL et al.. (2020)
LW-213, a newly synthesized flavonoid, induces G2/M phase arrest and apoptosis in chronic myeloid leukemia. Acta Pharmacol Sin, 41 (2): 249-259. [PMID:31316178] |
2. Wang J, Ge R, Qiu X, Xu X, Wei L, Li Z, Bian J. (2017)
Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro. Eur J Med Chem, 140: 421-434. [PMID:28987604] |
3. Yu XX, Zhu MY, Wang JR, Li H, Hu P, Qing YJ, Wang XY, Wang HZ. (2020)
LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK-eIF2α-ATF4-CHOP axis. Acta Pharmacol Sin,. DOI: 10.1038/s41401-020-0466-7 [PMID:32747719] |
4. Zhao L, Miao HC, Li WJ, Sun Y, Huang SL, Li ZY, Guo QL. (2016)
LW-213 induces G2/M cell cycle arrest through AKT/GSK3β/β-catenin signaling pathway in human breast cancer cells. Mol Carcinog, 55 (5): 778-92. [PMID:25945460] |