Synonyms: RB 3007 | RB-3007
Compound class:
Synthetic organic
Comment: RB3007 is a systemically delivered, dual inhibitor of the enkephalin-degrading enzymes neutral endopeptidase/aminopeptidase N [1]. It can be used as an in vivo biological tool. Aminopeptidase N/neprilysin inhibition with RB3007 induces an elevation in the levels of the two endogenous enkephalins [Met]enkephalin and [Leu]enkephalin, Prodrugs with this mechanism of action are known collectively as Dual Enkephalinase Inhibitors, or DENKIs.
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Bioactivity Comments |
RB3007 produces antinociceptive effects in vivo [1]. |