Synonyms: RB 3007 | RB-3007
Compound class:
Synthetic organic
Comment: RB3007 is a systemically delivered, dual inhibitor of the enkephalin-degrading enzymes neutral endopeptidase/aminopeptidase N [1]. It can be used as an in vivo biological tool. Aminopeptidase N/neprilysin inhibition with RB3007 induces an elevation in the levels of the two endogenous enkephalins [Met]enkephalin and [Leu]enkephalin, Prodrugs with this mechanism of action are known collectively as Dual Enkephalinase Inhibitors, or DENKIs.
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References |
1. Le Guen S, Mas Nieto M, Canestrelli C, Chen H, Fournié-Zaluski MC, Cupo A, Maldonado R, Roques BP, Noble F. (2003)
Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone. Pain, 104 (1-2): 139-48. [PMID:12855323] |