sirexatamab   Click here for help

GtoPdb Ligand ID: 11760

Synonyms: DKN-01 | LY-2812176 | LY2812176
Compound class: Antibody
Comment: Sirexatamab (DKN-01, formerly LY-2812176) is a humanised, IgG4-κ anti-DKK1 (dickkopf WNT signaling pathway inhibitor 1) monoclonal antibody that was developed by Leap Therapeutics for potential anti-cancer activity [2,5].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Dickkopf 1 Hs Antibody Inhibition - - - 3
⤷ [3]