Synonyms: CK-107 | CK-2127107 | CK2127107
Compound class:
Synthetic organic
Comment: Reldesemtiv (CK-2127107) is a second generation fast skeletal muscle troponin activator [1], that was designed to improve upon tirasemtiv. Reldesemtiv slows the rate of calcium release from the troponin complex, and sensitises the sarcomere to calcium which leads to increased contractility in fast skeletal muscle fibres. Like tirasemtiv, reldesemtiv was proposed to offer a therapeutic option for debilitating muscle weakness/muscle fatigue in diseases such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS).
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Bioactivity Comments |
Reldesemtiv (CK-2127107) improves skeletal muscle force and exercise performance in both healthy rats and in a model of neuromuscular disease (heart failure-mediated skeletal myopathy) [1]. |