A-349821

Ligand id: 1217

Name: A-349821

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 0
Rotatable bonds 12
Topological polar surface area 97.36
Molecular weight 320.15
XLogP 0.49
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
H3 receptor Hs Antagonist Inverse agonist 9.4 pKi - 1
pKi 9.4 [1]
H3 receptor Rn Antagonist Inverse agonist 8.8 pKi - 1
pKi 8.8 [1]
H1 receptor Hs Antagonist Inverse agonist 5.6 pKi - 1
pKi 5.6 [1]