Synonyms: FX 909 | FX909
Compound class:
Synthetic organic
Comment: FX-909 is a first-in-class oral, covalent inverse agonist of the peroxisome proliferator activated receptor gamma (PPARG) nuclear hormone receptor [1]. It was developed for anti-tumour potential. The chemical structure was disclosed during the 'First Disclosures of New Drug Candidates' session at the April 2023 (Orlando) meeting of the AACR.
|
|
Bioactivity Comments |
FX-909 is >2000-fold selective for PPARG compared to PPARA/PPARD [1]. |