Synonyms: FX 909 | FX909
Compound class:
Synthetic organic
Comment: FX-909 is a first-in-class oral, covalent inverse agonist of the peroxisome proliferator activated receptor gamma (PPARG) nuclear hormone receptor [1]. It was developed for anti-tumour potential. The chemical structure was disclosed during the 'First Disclosures of New Drug Candidates' session at the April 2023 (Orlando) meeting of the AACR.
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References |
1. Sims R, Mertz JA, Wilson JE, Audia JE, Williamson KE, Li Y, Kuljanin M, Motely WW, DeLaBarre B,Bowden M et al.. (2023)
Abstract ND08: Discovery of FX-909, a first-in-class inverse agonist of the peroxisome proliferator-activated receptor gamma (PPARG) lineage transcription factor, to potentially treat patients with the luminal subtype of advanced urothelial cancer (UC). Cancer Research, 83 (7_Supplement). DOI: 10.1158/1538-7445.AM2023-ND08 |